Psme1 MGI Mouse Gene Detail - MGI:1096367 - proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

Symbol

Psme1
Name

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
Synonyms

PA28a

Feature Type

protein coding gene
IDs

MGI:1096367
NCBI Gene: 19186
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:55815951-55818984 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.19 cM, cytoband C2-D1
Mapping Data

8 experiments

SNPs within 2kb

39 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096367	protein coding gene	Chr14:55815580-55818986 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021351	protein coding gene	Chr14:49613266-49616672 (+)
A/J	MGP_AJ_G0021310	protein coding gene	Chr14:48624543-48627949 (+)
AKR/J	MGP_AKRJ_G0021286	protein coding gene	Chr14:50370622-50374028 (+)
BALB/cJ	MGP_BALBcJ_G0021314	protein coding gene	Chr14:48570921-48574327 (+)
C3H/HeJ	MGP_C3HHeJ_G0021094	protein coding gene	Chr14:50057224-50060630 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021752	protein coding gene	Chr14:52108833-52112239 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019299	protein coding gene	Chr14:46999787-47003128 (+)
CAST/EiJ	MGP_CASTEiJ_G0020613	protein coding gene	Chr14:46321813-46325257 (+)
CBA/J	MGP_CBAJ_G0021061	protein coding gene	Chr14:53662978-53666384 (+)
DBA/2J	MGP_DBA2J_G0021182	protein coding gene	Chr14:48350714-48354120 (+)
FVB/NJ	MGP_FVBNJ_G0021164	protein coding gene	Chr14:47799264-47802673 (+)
LP/J	MGP_LPJ_G0021256	protein coding gene	Chr14:50657670-50661076 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021188	protein coding gene	Chr14:53024765-53028174 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021779	protein coding gene	Chr14:49559415-49562821 (+)
PWK/PhJ	MGP_PWKPhJ_G0020360	protein coding gene	Chr14:44882079-44885672 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020188	protein coding gene	Chr14:45563009-45566417 (+)
WSB/EiJ	MGP_WSBEiJ_G0020666	protein coding gene	Chr14:49843059-49846468 (+)

Human Ortholog

PSME1, proteasome activator subunit 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PSME1, proteasome activator subunit 1
Synonyms

HEL-S-129m, IFI5111, PA28A, PA28alpha, REGalpha
Links

HGNC:9568

NCBI Gene ID: 5720

neXtProt AC: NX_Q06323

UniProt: Q06323
Chr Location

14q12; chr14:24136163-24138967 (+) GRCh38

MGI Vertebrate Homology

Psme1 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: PSME1
Gene Tree

Psme1

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

3
Targeted

4
Genomic Mutations

1 involving Psme1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available

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All GO Annotations

9
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

804
Tissues

39
cDNA Data

154
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase psme1

ZFIN psme1

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All Sequences

63
RefSeq

2
UniProt

7
CCDS

CCDS36931.1

Ensembl

ENSMUSG00000022216 (Evidence)
NCBI Gene

19186

			Length	Strain/Species	Flank
genomic	19186	NCBI Gene Model \| MGI Sequence Detail	3034	C57BL/6J	± kb
transcript	NM_011189	RefSeq \| MGI Sequence Detail	977	ZRU/MplStud
polypeptide	P97371	UniProt \| EBI \| MGI Sequence Detail	249	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000013392 proteasome activator complex subunit 1

(term hierarchy)
PDB

5MSJ, 5MX5
InterPro Domains

IPR009077 Proteasome activator PA28

IPR003186 Proteasome activator PA28, C-terminal domain

IPR036997 Proteasome activator PA28, C-terminal domain superfamily

IPR003185 Proteasome activator PA28, N-terminal domain

IPR036996 Proteasome activator PA28, N-terminal domain superfamily

IPR036252 Proteasome activator superfamily

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All nucleic 157

Genomic 2

cDNA 154

Primer pair 1

Microarray probesets 3

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MGI:2145813

Summaries

All 59

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 22
Earliest

J:32937 Groettrup M, et al., A role for the proteasome regulator PA28alpha in antigen presentation. Nature. 1996 May 9;381(6578):166-8
Latest

J:304758 Adelof J, et al., PA28alpha overexpressing female mice maintain exploratory behavior and capacity to prevent protein aggregation in hippocampus as they age. Aging Cell. 2021 Apr;20(4):e13336

TSS for Psme1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125778	Chr14:55815618-55815637 (+)	-323 bp
Tssr125779	Chr14:55815813-55815823 (+)	-133 bp
Tssr125780	Chr14:55815879-55815894 (+)	-64 bp
Tssr125781	Chr14:55815901-55815996 (+)	-2 bp
Tssr125782	Chr14:55815999-55816018 (+)	58 bp
Tssr125783	Chr14:55818371-55818405 (+)	2,437 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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