Ptprq MGI Mouse Gene Detail - MGI:1096349 - protein tyrosine phosphatase receptor type Q

Symbol

Ptprq
Name

protein tyrosine phosphatase receptor type Q

Feature Type

protein coding gene
IDs

MGI:1096349
NCBI Gene: 237523
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr10:107352910-107555912 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 55.97 cM
Mapping Data

4 experiments

SNPs within 2kb

6243 from dbSNP Build 142
Strain Annotations

19
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096349	protein coding gene	Chr10:107350224-107555939 (-)
129S1/SvImJ	ENSMUSG00200010768	protein coding gene	Chr10:103773145-103976145 (-)
A/J	ENSMUSG00195008267	protein coding gene	Chr10:104180993-104384050 (-)
AKR/J	ENSMUSG00220024416	protein coding gene	Chr10:103748261-103952673 (-)
BALB/cJ	ENSMUSG00180023130	protein coding gene	Chr10:104194060-104397092 (-)
C3H/HeJ	ENSMUSG00175015392	protein coding gene	Chr10:104130220-104333245 (-)
C57BL/6NJ	ENSMUSG00215007891	protein coding gene	Chr10:103851471-104054488 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015787	protein coding gene	Chr10:100521972-100721275 (-)
CAST/EiJ	ENSTCUG00005011344	protein coding gene	Chr10:103255130-103453241 (-)
CBA/J	ENSMUSG00210011189	protein coding gene	Chr10:104007978-104210990 (-)
DBA/2J	ENSMUSG00185023916	protein coding gene	Chr10:104129986-104332990 (-)
FVB/NJ	ENSMUSG00205009566	protein coding gene	Chr10:103632172-103835191 (-)
JF1/MsJ	ENSUMUG00000008654	protein coding gene	Chr10:105535170-105733739 (-)
LP/J	ENSMUSG00230011796	protein coding gene	Chr10:106083217-106286227 (-)
NOD/ShiLtJ	ENSMUSG00190020259	protein coding gene	Chr10:104229498-104434987 (-)
NZO/HlLtJ	ENSMUSG00225040565	protein coding gene	Chr10:110338849-110541835 (-)
PWK/PhJ	ENSLUMG00010013399	protein coding gene	Chr10:103832083-104035972 (-)
SPRET/EiJ	ENSMSPG00010005281	protein coding gene	Chr10:105655083-105863628 (-)
WSB/EiJ	ENSIUOG00005010080	protein coding gene	Chr10:103901914-104104664 (-)

Human Ortholog

PTPRQ, protein tyrosine phosphatase receptor type Q

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTPRQ, protein tyrosine phosphatase receptor type Q
Synonyms

DFNA73, DFNB84, DFNB84A, PTPGMC1, R-PTP-Q
Links

HGNC:9679

NCBI Gene ID: 374462

UniProt: Q9UMZ3
Chr Location

12q21.31; chr12:80402178-80680273 (+) GRCh38

MGI Vertebrate Homology

Ptprq stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PTPRQ
Gene Tree

Ptprq

Diseases

2 with human PTPRQ associations

				Human Disease	Mouse Models
				autosomal dominant nonsyndromic deafness 73 IDs autosomal dominant nonsyndromic deafness 73 DOID:0080269 OMIM:617663
				autosomal recessive nonsyndromic deafness 84A IDs autosomal recessive nonsyndromic deafness 84A DOID:0110529 ICD10CM:H90.3 OMIM:613391

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

15 phenotypes from 3 alleles in 3 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

4
Genomic Mutations

1 involving Ptprq
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

132 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted mutations show absence of shaft connectors from vestibular hair bundles, postnatal degeneration in cochlear hair-bundle structure, reduced transducer currents but otherwise normal adaptation properties, a progressive loss of basal-coil cochlear hair cells, and deafness.

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All GO Annotations

28
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

625
Tissues

10
cDNA Data

2
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

ZFIN ptprq

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All Sequences

39
RefSeq

9
UniProt

2
CCDS

CCDS36051.1

Ensembl

ENSMUSG00000035916 (Evidence)
NCBI Gene

237523

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035916	Ensembl Gene Model \| MGI Sequence Detail	203003	C57BL/6J	± kb
transcript	ENSMUST00000050702	Ensembl \| MGI Sequence Detail	7393	Not Applicable
polypeptide	ENSMUSP00000058572	Ensembl \| MGI Sequence Detail	2300	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013477 phosphotidylinositol phosphatase PTPRQ

(term hierarchy)
EC

3.1.3.36, 3.1.3.67, 3.1.3.86, 3.1.3.95
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR050713 Receptor-type Tyrosine-protein Phosphatases/Ushers

IPR000242 Tyrosine-specific protein phosphatase, PTPase domain

IPR000387 Tyrosine-specific protein phosphatases domain
GlyGen

P0C5E4 17 sites, 1 O-linked glycan (1 site)

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All nucleic 8

Genomic 3

cDNA 2

Primer pair 3

Antibodies 4

Microarray probesets 1

Summaries

All 47

Developmental Gene Expression 7

Gene Ontology 13

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:388916 Xia R, et al., Therapeutic restoration of miR-96 prevents hearing loss in mice through modulation of noise-induced and genetic pathways. iScience. 2025 May 16;28(5):112355

TSS for Ptprq:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99195	Chr10:107555839-107555850 (-)	67 bp
Tssr3346	Chr10:107555836-107555839 (-)	74 bp
Tssr99194	Chr10:107555768-107555818 (-)	119 bp
Tssr99193	Chr10:107555754-107555761 (-)	154 bp
Tssr99192	Chr10:107479423-107479432 (-)	76,484 bp
Tssr99191	Chr10:107479404-107479418 (-)	76,501 bp
Tssr99190	Chr10:107382950-107382954 (-)	172,960 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24