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Ephb1 Gene Detail
Summary
  • Symbol
    Ephb1
  • Name
    Eph receptor B1
  • Synonyms
    C130099E04Rik, Cek6, Elk, Elkh, Hek6, Net
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096337
    NCBI Gene: 270190
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:101799327-102231892 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 54.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11338 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096337
 protein coding gene Chr9:101799327-102231892 (-)
129S1/SvImJ ENSMUSG00200016142
 protein coding gene Chr9:98950016-99394479 (-)
A/J ENSMUSG00195018165
 protein coding gene Chr9:98172787-98617260 (-)
AKR/J ENSMUSG00220037212
 protein coding gene Chr9:98567622-99005915 (-)
BALB/cJ ENSMUSG00180023411
 protein coding gene Chr9:98489513-98933964 (-)
C3H/HeJ ENSMUSG00175011994
 protein coding gene Chr9:98832150-99276622 (-)
C57BL/6NJ ENSMUSG00215009584
 protein coding gene Chr9:98823438-99256094 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032576
 protein coding gene Chr9:97356233-97788159 (-)
CAST/EiJ ENSTCUG00005012442
 protein coding gene Chr9:98616900-99057801 (-)
CBA/J ENSMUSG00210015010
 protein coding gene Chr9:98671395-99115839 (-)
DBA/2J ENSMUSG00185010963
 protein coding gene Chr9:98839358-99283850 (-)
FVB/NJ ENSMUSG00205016184
 protein coding gene Chr9:98849810-99283247 (-)
JF1/MsJ ENSUMUG00000029617
 protein coding gene Chr9:98681435-99112825 (-)
LP/J ENSMUSG00230016606
 protein coding gene Chr9:98999940-99426080 (-)
NOD/ShiLtJ ENSMUSG00190036438
 protein coding gene Chr9:98455109-98919665 (-)
NZO/HlLtJ ENSMUSG00225019874
 protein coding gene Chr9:99212223-99644832 (-)
PWK/PhJ ENSLUMG00010026702
 protein coding gene Chr9:98609725-99041066 (-)
SPRET/EiJ ENSMSPG00010003621
 protein coding gene Chr9:100471969-100905857 (-)
WSB/EiJ ENSIUOG00005022966
 protein coding gene Chr9:97926959-98353492 (-)



Homology
more
  • Human Ortholog
    EPHB1, EPH receptor B1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPHB1, EPH receptor B1
  • Synonyms
    ELK, EPHT2, Hek6, NET
  • Links
    NCBI Gene ID: 2047
    UniProt: P54762

  • Chr Location
    3q22.2; chr3:134795260-135260467 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EPHB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 5 alleles in 4 genetic backgrounds
    11 phenotypes from multigenic genotypes
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene display marked reductions of the ipsilateral optic tract. Homozygotes for one null allele show reduced corticospinal tract and abnormal anterior commissure axon crossing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    111
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1068
  • Tissues
    281
  • cDNA Data
    58
  • Literature Summary
    109
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 270190 NCBI Gene Model | MGI Sequence Detail 432566 C57BL/6J ±  kb
    transcript NM_173447 RefSeq | MGI Sequence Detail 4686 C57BL/6  
    polypeptide Q8CBF3 UniProt | EBI | MGI Sequence Detail 984 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007129 ephrin type-B receptor 1
      (term hierarchy)
    • EC
      2.7.10.1
    • InterPro Domains
      IPR042819 EphB1 , SAM domain
      IPR061283 Ephrin, cysteine rich domain
      IPR001090 Ephrin, ligand binding domain
      IPR016257 Ephrin receptor type-A /type-B
      IPR050449 Ephrin receptor tyrosine kinases
      IPR027936 Ephrin, transmembrane domain
      IPR034231 Ephrin type-B receptor 1, ligand binding domain
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR008979 Galactose-binding-like domain superfamily
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
      IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
    • GlyGen
      Q8CBF3 4 sites, 3 N-linked glycans (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 61
      Primer pair 6
      Other 4
      Antibodies 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-32154, MGI:105114, MGI:2143306, MGI:3712490
    References
    more
    • Summaries
      All 216
      Developmental Gene Expression 109
      Gene Ontology 26
      Phenotypes 60
    • Earliest
      J:23894 Mori T, et al., Differential expressions of the eph family of receptor tyrosine kinase genes (sek, elk, eck) in the developing nervous system of the mouse. Brain Res Mol Brain Res. 1995 Apr;29(2):325-35
    • Latest
      J:385781 Tang T, et al., Ribosomal Profiling of the Geniculate Ganglion Identifies the Receptor ALK as Critical for the Development and Maintenance of Oral Sensory Neurons. J Neurosci. 2026 Apr 8;46(14)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory