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Rax Gene Detail
Summary
  • Symbol
    Rax
  • Name
    retina and anterior neural fold homeobox
  • Synonyms
    E130303K03Rik, ey1, Rx
  • Feature Type
    protein coding gene
  • IDs
    MGI:109632
    NCBI Gene: 19434
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:66067710-66072160 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 39.03 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109632
 protein coding gene Chr18:66061348-66072858 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024513
 protein coding gene Chr18:66123451-66127902 (-)
A/J MGP_AJ_G0024480
 protein coding gene Chr18:63233283-63237734 (-)
AKR/J MGP_AKRJ_G0024450
 protein coding gene Chr18:65019568-65024019 (-)
BALB/cJ MGP_BALBcJ_G0024479
 protein coding gene Chr18:63375501-63379952 (-)
C3H/HeJ MGP_C3HHeJ_G0024247
 protein coding gene Chr18:65232919-65237370 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024926
 protein coding gene Chr18:67874939-67879389 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022357
 protein coding gene Chr18:62676014-62680428 (-)
CAST/EiJ MGP_CASTEiJ_G0023720
 protein coding gene Chr18:65232981-65237461 (-)
CBA/J MGP_CBAJ_G0024217
 protein coding gene Chr18:70121265-70125716 (-)
DBA/2J MGP_DBA2J_G0024347
 protein coding gene Chr18:62902268-62906719 (-)
FVB/NJ MGP_FVBNJ_G0024313
 protein coding gene Chr18:62278781-62283231 (-)
LP/J MGP_LPJ_G0024431
 protein coding gene Chr18:65969538-65973989 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024342
 protein coding gene Chr18:71511196-71515646 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024973
 protein coding gene Chr18:65234400-65238850 (-)
PWK/PhJ MGP_PWKPhJ_G0023463
 protein coding gene Chr18:63155529-63159982 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023268
 protein coding gene Chr18:65393595-65398047 (-)
WSB/EiJ MGP_WSBEiJ_G0023784
 protein coding gene Chr18:65098201-65102651 (-)



Homology
more
  • Human Ortholog
    RAX, retina and anterior neural fold homeobox
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAX, retina and anterior neural fold homeobox
  • Synonyms
    MCOP3, MCOPS16, RAX1, RX
  • Links
    NCBI Gene ID: 30062
    neXtProt AC: NX_Q9Y2V3
    UniProt: Q9Y2V3

  • Chr Location
    18q21.32; chr18:59267035-59274086 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RAX associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 7 alleles in 7 genetic backgrounds
    4 phenotypes from multigenic genotypes
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die neonatally with severe brain defects including absence of forebrain/midbrain structures and fail to form eye structures. Homozygous hypomorph mutants are viable, but lack eyes and optic tracts and have hypothalamic defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1167
  • Tissues
    273
  • cDNA Data
    21
  • Literature Summary
    95
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19434 NCBI Gene Model | MGI Sequence Detail 4451 C57BL/6J ±  kb
    transcript NM_013833 RefSeq | MGI Sequence Detail 1687 Not Specified  
    polypeptide O35602 UniProt | EBI | MGI Sequence Detail 342 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 22
      Primer pair 6
      Other 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39631, MGD-MRK-9688, MGD-MRK-9690, MGI:2442635, MGI:95470
    References
    more
    • Summaries
      All 180
      Developmental Gene Expression 95
      Gene Ontology 11
      Phenotypes 69
    • Earliest
      J:229 Chase HB, Studies on an Anophthalmic Strain of Mice. IV. a Second Major Gene for Anophthalmia. Genetics. 1944 May;29(3):264-9
    • Latest
      J:343696 Yoshimoto T, et al., The Rax homeoprotein in Muller glial cells is required for homeostasis maintenance of the postnatal mouse retina. J Biol Chem. 2023 Nov 15;299(12):105461
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory