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Matn2 Gene Detail
Summary
  • Symbol
    Matn2
  • Name
    matrilin 2
  • Synonyms
    Crtm2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109613
    NCBI Gene: 17181
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:34306827-34436388 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 13.98 cM, cytoband B3.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3866 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109613
 protein coding gene Chr15:34306823-34436419 (+)
129S1/SvImJ ENSMUSG00200025393
 protein coding gene Chr15:31297036-31432396 (+)
A/J ENSMUSGG00195055260
 protein coding gene Chr15:31237663-31274682 (+)
AKR/J ENSMUSGG00220054683
 protein coding gene Chr15:31140475-31177485 (+)
BALB/cJ ENSMUSGG00180055464
 protein coding gene Chr15:31194327-31231329 (+)
C3H/HeJ ENSMUSG00175026754
 protein coding gene Chr15:31373105-31502953 (+)
C57BL/6NJ ENSMUSG00215013968
 protein coding gene Chr15:31215586-31345456 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019721
 protein coding gene Chr15:29249910-29386371 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210017803
 protein coding gene Chr15:31320902-31450763 (+)
DBA/2J ENSMUSG00185032295
 protein coding gene Chr15:31305640-31435494 (+)
FVB/NJ ENSMUSGG00205054494
 protein coding gene Chr15:31195462-31232478 (+)
JF1/MsJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ ENSMUSG00225031749
 protein coding gene Chr15:34997108-35126958 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010012711
 protein coding gene Chr15:31962657-32105236 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MATN2, matrilin 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MATN2, matrilin 2
  • Links
    NCBI Gene ID: 4147
    UniProt: O00339

  • Chr Location
    8q22.1-q22.2; chr8:97868840-98036769 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    18 phenotype references
Homozygous null mice are healthy and fertile with no obvious abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    38
  • cDNA Data
    35
  • Literature Summary
    15
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17181 NCBI Gene Model | MGI Sequence Detail 129562 C57BL/6J ±  kb
transcript NM_001358780 RefSeq | MGI Sequence Detail 3577 C57BL/6  
polypeptide O08746 UniProt | EBI | MGI Sequence Detail 956 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 37
    Antibodies 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39612
References
more
  • Summaries
    All 68
    Developmental Gene Expression 15
    Gene Ontology 13
    Phenotypes 18
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:369139 Liu L, et al., SEMA3B switches axon-axon to axon-glia interactions required for unmyelinated axon envelopment and integrity. Nat Commun. 2025 Jul 1;16(1):5433
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory