Cntn4 MGI Mouse Gene Detail - MGI:1095737

Symbol

Cntn4
Name

contactin 4
Synonyms

Axcam, BIG-2A

Feature Type

protein coding gene
IDs

MGI:1095737
NCBI Gene: 269784
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:105654621-106676271 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 48.93 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

9731 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1095737	protein coding gene	Chr6:105654505-106677102 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031093	protein coding gene	Chr6:107861107-108935746 (+)
A/J	MGP_AJ_G0031062	protein coding gene	Chr6:103744953-104765465 (+)
AKR/J	MGP_AKRJ_G0030993	protein coding gene	Chr6:106546234-107592245 (+)
BALB/cJ	MGP_BALBcJ_G0031073	protein coding gene	Chr6:103708671-104721866 (+)
C3H/HeJ	MGP_C3HHeJ_G0030635	protein coding gene	Chr6:76739112-77803331 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031532	protein coding gene	Chr6:110637509-111771759 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028696	protein coding gene	Chr6:101236735-102227097 (+)
CAST/EiJ	MGP_CASTEiJ_G0030180	protein coding gene	Chr6:106931664-108002888 (+)
CBA/J	MGP_CBAJ_G0030759	protein coding gene	Chr6:114957492-116107328 (+)
DBA/2J	MGP_DBA2J_G0030912	protein coding gene	Chr6:102890316-103900667 (+)
FVB/NJ	MGP_FVBNJ_G0030866	protein coding gene	Chr6:101982665-102997112 (+)
LP/J	MGP_LPJ_G0030992	protein coding gene	Chr6:107963940-109025002 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030900	protein coding gene	Chr6:119101106-120363157 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031559	protein coding gene	Chr6:106527739-107587335 (+)
PWK/PhJ	MGP_PWKPhJ_G0029896	protein coding gene	Chr6:101865264-102898350 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029724	protein coding gene	Chr6:105378023-106417367 (+)
WSB/EiJ	MGP_WSBEiJ_G0030264	protein coding gene	Chr6:107036439-108109569 (+)

Human Ortholog

CNTN4, contactin 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CNTN4, contactin 4
Synonyms

AXCAM, BIG-2
Links

HGNC:2174

NCBI Gene ID: 152330

neXtProt AC: NX_Q8IWV2

UniProt: Q8IWV2
Chr Location

3p26.3-p26.2; chr3:2098813-3057959 (+) GRCh38

MGI Vertebrate Homology

Cntn4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CNTN4
Gene Tree

Cntn4

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Gene trapped

1
Spontaneous

1
Targeted

3
Genomic Mutations

1 involving Cntn4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit aberrant projection of olfactory axons to multiple glomeruli in the olfactory bulb.

less

All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

32
cDNA Data

20
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cntn4

less

All Sequences

114
RefSeq

64
UniProt

3
CCDS

CCDS20395.1, CCDS51866.1

Ensembl

ENSMUSG00000064293 (Evidence)
NCBI Gene

269784

			Length	Strain/Species	Flank
genomic	ENSMUSG00000064293	Ensembl Gene Model \| MGI Sequence Detail	1021651	C57BL/6J	± kb
transcript	ENSMUST00000113264	Ensembl \| MGI Sequence Detail	5262	Not Applicable
polypeptide	ENSMUSP00000108889	Ensembl \| MGI Sequence Detail	1026	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000005669 contactin-4

(term hierarchy)
PDB

3JXA, 3KLD, 5E4S
InterPro Domains

IPR033007 Contactin-4, Ig6

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

less

All nucleic 25

cDNA 23

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 55

Developmental Gene Expression 13

Gene Ontology 6

Phenotypes 15
Earliest

J:41456 Mimmack ML, et al., A novel splice variant of the cell adhesion molecule BIG-2 is expressed in the olfactory and vomeronasal neuroepithelia. Brain Res Mol Brain Res. 1997 Jul;47(1-2):345-50
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Cntn4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58036	Chr6:105654604-105654699 (+)	31 bp
Tssr58037	Chr6:105654709-105654722 (+)	95 bp
Tssr58038	Chr6:105654729-105654755 (+)	121 bp
Tssr58039	Chr6:105654772-105654792 (+)	161 bp
Tssr58040	Chr6:106095885-106095913 (+)	441,278 bp
Tssr58041	Chr6:106309405-106309407 (+)	654,785 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23