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Cntn4 Gene Detail
Summary
  • Symbol
    Cntn4
  • Name
    contactin 4
  • Synonyms
    Axcam, BIG-2A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095737
    NCBI Gene: 269784
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:105654621-106676271 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 48.93 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    28364 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1095737
protein coding gene Chr6:105654505-106677102 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031093
protein coding gene Chr6:107861107-108935746 (+)
A/J MGP_AJ_G0031062
protein coding gene Chr6:103744953-104765465 (+)
AKR/J MGP_AKRJ_G0030993
protein coding gene Chr6:106546234-107592245 (+)
BALB/cJ MGP_BALBcJ_G0031073
protein coding gene Chr6:103708671-104721866 (+)
C3H/HeJ MGP_C3HHeJ_G0030635
protein coding gene Chr6:76739112-77803331 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031532
protein coding gene Chr6:110637509-111771759 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028696
protein coding gene Chr6:101236735-102227097 (+)
CAST/EiJ MGP_CASTEiJ_G0030180
protein coding gene Chr6:106931664-108002888 (+)
CBA/J MGP_CBAJ_G0030759
protein coding gene Chr6:114957492-116107328 (+)
DBA/2J MGP_DBA2J_G0030912
protein coding gene Chr6:102890316-103900667 (+)
FVB/NJ MGP_FVBNJ_G0030866
protein coding gene Chr6:101982665-102997112 (+)
LP/J MGP_LPJ_G0030992
protein coding gene Chr6:107963940-109025002 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030900
protein coding gene Chr6:119101106-120363157 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031559
protein coding gene Chr6:106527739-107587335 (+)
PWK/PhJ MGP_PWKPhJ_G0029896
protein coding gene Chr6:101865264-102898350 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029724
protein coding gene Chr6:105378023-106417367 (+)
WSB/EiJ MGP_WSBEiJ_G0030264
protein coding gene Chr6:107036439-108109569 (+)



Homology
more
  • Human Ortholog
    CNTN4, contactin 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNTN4, contactin 4
  • Synonyms
    AXCAM, BIG-2
  • Links
    NCBI Gene ID: 152330
    neXtProt AC: NX_Q8IWV2
    UniProt: Q8IWV2

  • Chr Location
    3p26.3-p26.2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit aberrant projection of olfactory axons to multiple glomeruli in the olfactory bulb.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000064293 Ensembl Gene Model | MGI Sequence Detail 1021651 C57BL/6J ±  kb
    transcript ENSMUST00000113264 Ensembl | MGI Sequence Detail 5262 Not Applicable  
    polypeptide ENSMUSP00000108889 Ensembl | MGI Sequence Detail 1026 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 23
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 13
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:41456 Mimmack ML, et al., A novel splice variant of the cell adhesion molecule BIG-2 is expressed in the olfactory and vomeronasal neuroepithelia. Brain Res Mol Brain Res. 1997 Jul;47(1-2):345-50
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory