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Tfpi Gene Detail
Summary
  • Symbol
    Tfpi
  • Name
    tissue factor pathway inhibitor
  • Synonyms
    A630013F22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095418
    NCBI Gene: 21788
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:84263199-84307119 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 49.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    843 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1095418
 protein coding gene Chr2:84263199-84307119 (-)
129S1/SvImJ ENSMUSG00200002911
 protein coding gene Chr2:81279586-81323515 (-)
A/J ENSMUSG00195047350
 protein coding gene Chr2:81407289-81451313 (-)
AKR/J ENSMUSG00220002150
 protein coding gene Chr2:81285983-81329989 (-)
BALB/cJ ENSMUSG00180054552
 protein coding gene Chr2:81335164-81379177 (-)
C3H/HeJ ENSMUSG00175010037
 protein coding gene Chr2:81474758-81518774 (-)
C57BL/6NJ ENSMUSG00215051294
 protein coding gene Chr2:81364679-81408603 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023718
 protein coding gene Chr2:78658823-78702797 (-)
CAST/EiJ ENSTCUG00005028154
 protein coding gene Chr2:80818969-80862978 (-)
CBA/J ENSMUSG00210030435
 protein coding gene Chr2:81502657-81546672 (-)
DBA/2J ENSMUSG00185011283
 protein coding gene Chr2:81331404-81375411 (-)
FVB/NJ ENSMUSG00205013028
 protein coding gene Chr2:80707563-80751693 (-)
JF1/MsJ ENSUMUG00000005850
 protein coding gene Chr2:81254722-81299024 (-)
LP/J ENSMUSG00230037091
 protein coding gene Chr2:83082506-83126532 (-)
NOD/ShiLtJ ENSMUSG00190045028
 protein coding gene Chr2:81362328-81406267 (-)
NZO/HlLtJ ENSMUSG00225001544
 protein coding gene Chr2:90957474-91001409 (-)
PWK/PhJ ENSLUMG00010029296
 protein coding gene Chr2:81270414-81314403 (-)
SPRET/EiJ ENSMSPG00010052004
 protein coding gene Chr2:83170971-83214958 (-)
WSB/EiJ ENSIUOG00005010666
 protein coding gene Chr2:81312832-81356727 (-)



Homology
more
  • Human Ortholog
    TFPI, tissue factor pathway inhibitor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TFPI, tissue factor pathway inhibitor
  • Synonyms
    EPI, LACI, TFI, TFPI1
  • Links
    NCBI Gene ID: 7035
    UniProt: P10646

  • Chr Location
    2q32.1; chr2:187463823-187565846 (-)  GRCh38
Human Diseases
more
  • Diseases
    10 with human TFPI associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 5 genetic backgrounds
    10 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant embryos die showing hemorrhages of the yolk sac, central nervous system, and tail.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    57
  • cDNA Data
    99
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21788 NCBI Gene Model | MGI Sequence Detail 43921 C57BL/6J ±  kb
    transcript NM_001177319 RefSeq | MGI Sequence Detail 3027 C57BL/6  
    polypeptide O54819 UniProt | EBI | MGI Sequence Detail 306 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000016279 tissue factor pathway inhibitor
      (term hierarchy)
    • InterPro Domains
      IPR002223 Pancreatic trypsin inhibitor Kunitz domain
      IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
      IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
      IPR050098 Tissue factor pathway inhibitor/Kunitz-type serine protease inhibitor-like
      IPR008296 Tissue factor pathway inhibitor-like
    • GlyGen
      O54819 4 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 104
      Genomic 1
      cDNA 101
      Primer pair 2
      Antibodies 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2139389, MGI:2443242
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 12
      Gene Ontology 8
      Phenotypes 39
    • Earliest
      J:41945 Huang ZF, et al., Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice. Blood. 1997 Aug 1;90(3):944-51
    • Latest
      J:387160 Maroney SA, et al., Defective cerebrovascular development in mice lacking TFPI is restored by activated protein C. Blood. 2026 May 21;147(21):2530-2540
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory