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Trpc2 Gene Detail
Summary
  • Symbol
    Trpc2
  • Name
    transient receptor potential cation channel, subfamily C, member 2
  • Synonyms
    3010009O07Rik, mTrp2, trp2, TRPC2a, TRPC2b, Trrp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109527
    NCBI Gene: 22064
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr7:101732323-101745603 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.71 cM, cytoband F1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109527
 protein coding gene Chr7:101732323-101746071 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032600
 protein coding gene Chr7:105112278-105127250 (+)
A/J MGP_AJ_G0032576
 protein coding gene Chr7:102432618-102447299 (+)
AKR/J MGP_AKRJ_G0032512
 protein coding gene Chr7:104884408-104898897 (+)
BALB/cJ MGP_BALBcJ_G0032587
 protein coding gene Chr7:102126404-102140224 (+)
C3H/HeJ MGP_C3HHeJ_G0032301
 protein coding gene Chr7:105262079-105275370 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033084
 protein coding gene Chr7:109078511-109091682 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030078
 protein coding gene Chr7:104787664-104801484 (+)
CAST/EiJ MGP_CASTEiJ_G0031627
 protein coding gene Chr7:96821350-96834846 (+)
CBA/J MGP_CBAJ_G0032267
 protein coding gene Chr7:112854298-112869295 (+)
DBA/2J MGP_DBA2J_G0032419
 protein coding gene Chr7:100758228-100772035 (+)
FVB/NJ MGP_FVBNJ_G0032375
 protein coding gene Chr7:100544845-100558145 (+)
LP/J MGP_LPJ_G0032508
 protein coding gene Chr7:106425004-106439729 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032409
 protein coding gene Chr7:114168613-114183030 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033106
 protein coding gene Chr7:104156804-104170087 (+)
PWK/PhJ MGP_PWKPhJ_G0031345
 protein coding gene Chr7:93877260-93891120 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031189
 protein coding gene Chr7:91450879-91466413 (+)
WSB/EiJ MGP_WSBEiJ_G0031744
 protein coding gene Chr7:104844619-104857837 (+)



Homology
more
  • Human Ortholog
    TRPC2, transient receptor potential cation channel subfamily C member 2 (pseudogene)
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPC2, transient receptor potential cation channel subfamily C member 2 (pseudogene)
  • Links
    NCBI Gene ID: 7221

  • Chr Location
    11p15.4; chr11:3616679-3637672 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 5 alleles in 7 genetic backgrounds
    11 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit altered sexual and social behavior, including intermale mounting and a lack of aggressive behavior in the presence of invading males. Homozygotes for another allele show increased triglyceride levels in both males and femalesand increased cholesterol in males.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    39
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    79
  • cDNA Data
    16
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000100254 Ensembl Gene Model | MGI Sequence Detail 13281 C57BL/6J ±  kb
    transcript ENSMUST00000124189 Ensembl | MGI Sequence Detail 2874 Not Applicable  
    polypeptide ENSMUSP00000116934 Ensembl | MGI Sequence Detail 890 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000001725 short transient receptor potential cation channel TRPC2
      (term hierarchy)
    • InterPro Domains
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR002706 DNA-repair protein Xrcc1, N-terminal
      IPR008979 Galactose-binding-like domain superfamily
      IPR005821 Ion transport domain
      IPR013555 Transient receptor ion channel domain
      IPR002153 Transient receptor potential channel, canonical
      IPR005458 Transient receptor potential channel, canonical 2
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 17
      Primer pair 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-39526, MGI:1924097, MGI:2141869
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 15
      Gene Ontology 17
      Phenotypes 61
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:342468 Pfau DR, et al., Loss of TRPC2 function in mice alters sex differences in brain regions regulating social behaviors. J Comp Neurol. 2023 Oct;531(15):1550-1561
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory