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Msh3 Gene Detail
Summary
  • Symbol
    Msh3
  • Name
    mutS homolog 3
  • Synonyms
    D13Em1, Rep-3, Rep3
  • Feature Type
    protein coding gene
  • IDs
    MGI:109519
    NCBI Gene: 17686
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:92348387-92491515 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 47.63 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4177 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109519
 protein coding gene Chr13:92348380-92491515 (-)
129S1/SvImJ ENSMUSG00200008756
 protein coding gene Chr13:86842298-86988170 (-)
A/J ENSMUSG00195023895
 protein coding gene Chr13:87358976-87500723 (-)
AKR/J ENSMUSG00220013702
 protein coding gene Chr13:85841615-85983487 (-)
BALB/cJ ENSMUSG00180015418
 protein coding gene Chr13:87883214-88024406 (-)
C3H/HeJ ENSMUSG00175023125
 protein coding gene Chr13:88061142-88203013 (-)
C57BL/6NJ ENSMUSG00215002954
 protein coding gene Chr13:87945475-88088613 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018767
 protein coding gene Chr13:85968812-86111444 (-)
CAST/EiJ ENSTCUG00005009015
 protein coding gene Chr13:87175200-87322169 (-)
CBA/J ENSMUSG00210024253
 protein coding gene Chr13:87338895-87484766 (-)
DBA/2J ENSMUSG00185017278
 protein coding gene Chr13:91024940-91170807 (-)
FVB/NJ ENSMUSG00205007842
 protein coding gene Chr13:86830044-86975916 (-)
JF1/MsJ ENSUMUG00000018892
 protein coding gene Chr13:90765257-90912245 (-)
LP/J ENSMUSG00230033934
 protein coding gene Chr13:101043043-101188915 (-)
NOD/ShiLtJ ENSMUSG00190017522
 protein coding gene Chr13:87727957-87871089 (-)
NZO/HlLtJ ENSMUSG00225032394
 protein coding gene Chr13:93575359-93717227 (-)
PWK/PhJ ENSLUMG00010011149
 protein coding gene Chr13:86867772-87016136 (-)
SPRET/EiJ ENSMSPG00010006467
 protein coding gene Chr13:88074794-88217553 (-)
WSB/EiJ ENSIUOG00005029836
 protein coding gene Chr13:86743475-86893380 (-)



Homology
more
  • Human Ortholog
    MSH3, mutS homolog 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MSH3, mutS homolog 3
  • Synonyms
    DUP, FAP4, MRP1
  • Links
    NCBI Gene ID: 4437
    UniProt: P20585

  • Chr Location
    5q14.1; chr5:80654650-80877147 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human MSH3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a partial defect mismatch repair and development of intestinal tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    611
  • Tissues
    6
  • cDNA Data
    81
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17686 NCBI Gene Model | MGI Sequence Detail 143129 C57BL/6J ±  kb
    transcript NM_010829 RefSeq | MGI Sequence Detail 3944 ZRU/MplStud  
    polypeptide P13705 UniProt | EBI | MGI Sequence Detail 1091 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000010667 DNA mismatch repair protein Msh3
      (term hierarchy)
    • InterPro Domains
      IPR045076 DNA mismatch repair MutS
      IPR007860 DNA mismatch repair protein MutS, connector domain
      IPR007696 DNA mismatch repair protein MutS, core
      IPR036187 DNA mismatch repair protein MutS, core domain superfamily
      IPR000432 DNA mismatch repair protein MutS, C-terminal
      IPR007695 DNA mismatch repair protein MutS-like, N-terminal
      IPR017261 DNA mismatch repair protein MutS/MSH
      IPR016151 DNA mismatch repair protein MutS, N-terminal
      IPR036678 MutS, connector domain superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      P13705 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 24
      cDNA 84
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13842, MGD-MRK-13845, MGD-MRK-3409, MGD-MRK-39518
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 34
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:362800 Bunting EL, et al., Antisense oligonucleotide-mediated MSH3 suppression reduces somatic CAG repeat expansion in Huntington's disease iPSC-derived striatal neurons. Sci Transl Med. 2025 Feb 12;17(785):eadn4600
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory