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Doc2a Gene Detail
Summary
  • Symbol
    Doc2a
  • Name
    double C2, alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:109446
    NCBI Gene: 13446
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126446588-126451877 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.25 cM, cytoband F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109446
 protein coding gene Chr7:126446525-126451877 (+)
129S1/SvImJ ENSMUSG00200024428
 protein coding gene Chr7:112958159-112963448 (+)
A/J ENSMUSG00195042819
 protein coding gene Chr7:117473685-117478974 (+)
AKR/J ENSMUSG00220020361
 protein coding gene Chr7:110906495-110911784 (+)
BALB/cJ ENSMUSG00180012697
 protein coding gene Chr7:114147347-114152636 (+)
C3H/HeJ ENSMUSG00175014207
 protein coding gene Chr7:114874852-114880141 (+)
C57BL/6NJ ENSMUSG00215022450
 protein coding gene Chr7:114154799-114160088 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030469
 protein coding gene Chr7:128867390-128872155 (+)
CAST/EiJ ENSTCUG00005046269
 protein coding gene Chr7:117370766-117376063 (+)
CBA/J ENSMUSG00210022783
 protein coding gene Chr7:114635919-114641208 (+)
DBA/2J ENSMUSG00185048826
 protein coding gene Chr7:118948784-118954073 (+)
FVB/NJ ENSMUSG00205018302
 protein coding gene Chr7:114594378-114599667 (+)
JF1/MsJ ENSUMUG00000021818
 protein coding gene Chr7:124002290-124007579 (+)
LP/J ENSMUSG00230052710
 protein coding gene Chr7:125058154-125063443 (+)
NOD/ShiLtJ ENSMUSG00190013070
 protein coding gene Chr7:114794926-114800215 (+)
NZO/HlLtJ ENSMUSG00225011906
 protein coding gene Chr7:123287614-123292903 (+)
PWK/PhJ ENSLUMG00010031332
 protein coding gene Chr7:113142215-113147504 (+)
SPRET/EiJ ENSMSPG00010009171
 protein coding gene Chr7:114414103-114419102 (+)
WSB/EiJ ENSIUOG00005023859
 protein coding gene Chr7:115496784-115502073 (+)



Homology
more
  • Human Ortholog
    DOC2A, double C2 domain alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DOC2A, double C2 domain alpha
  • Synonyms
    Doc2
  • Links
    NCBI Gene ID: 8448
    UniProt: Q14183

  • Chr Location
    16p11.2; chr16:30005507-30023270 (-)  GRCh38
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this locus affects excitatory synaptic transmission, LTP, and learning/memory. Adult mice heterozygous for a knock-out allele show increased secondary somatosensory cortex size in males and increased corpus callosum, cingulate cortex, and primary motor cortex size in females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    1
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052301 Ensembl Gene Model | MGI Sequence Detail 5290 C57BL/6J ±  kb
    transcript ENSMUST00000064110 Ensembl | MGI Sequence Detail 2538 Not Applicable  
    polypeptide ENSMUSP00000070119 Ensembl | MGI Sequence Detail 405 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7
      Antibodies 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-38491
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 2
      Diseases 3
      Gene Ontology 10
      Phenotypes 64
    • Earliest
      J:39762 Kojima T, et al., Calcium-dependent phospholipid binding to the C2A domain of a ubiquitous form of double C2 protein (Doc2 beta). J Biochem. 1996 Sep;120(3):671-6
    • Latest
      J:389705 Hao L, et al., Heart rate and sleep history encode ultradian REM sleep timing. Curr Biol. 2026 Mar 23;36(6):1422-1434.e5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory