Slc4a3 MGI Mouse Gene Detail - MGI:109350 - solute carrier family 4 (anion exchanger), member 3

Symbol

Slc4a3
Name

solute carrier family 4 (anion exchanger), member 3
Synonyms

A930038D23Rik, Ae3

Feature Type

protein coding gene
IDs

MGI:109350
NCBI Gene: 20536
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:75522688-75536075 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 39.16 cM, cytoband C3
Mapping Data

5 experiments

SNPs within 2kb

334 from dbSNP Build 142
Strain Annotations

27
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109350	protein coding gene	Chr1:75522688-75538816 (+)
129S1/SvImJ	ENSMUSGG00200054403	protein coding gene	Chr1:73189886-73192539 (+)
129S1/SvImJ	ENSMUSG00200035044	protein coding gene	Chr1:73187059-73188325 (+)
A/J	ENSMUSG00195008197	protein coding gene	Chr1:72611310-72612576 (+)
A/J	ENSMUSGG00195054903	protein coding gene	Chr1:72614137-72616790 (+)
AKR/J	ENSMUSG00220010061	protein coding gene	Chr1:72762087-72763353 (+)
AKR/J	ENSMUSGG00220054586	protein coding gene	Chr1:72764914-72767567 (+)
BALB/cJ	ENSMUSG00180019357	protein coding gene	Chr1:72873220-72874486 (+)
BALB/cJ	ENSMUSGG00180055337	protein coding gene	Chr1:72876047-72878700 (+)
C3H/HeJ	ENSMUSGG00175054703	protein coding gene	Chr1:73014508-73017161 (+)
C3H/HeJ	ENSMUSG00175017669	protein coding gene	Chr1:73011681-73012947 (+)
C57BL/6NJ	ENSMUSGG00215055718	protein coding gene	Chr1:72921373-72924026 (+)
C57BL/6NJ	ENSMUSG00215013598	protein coding gene	Chr1:72918546-72919812 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014306	protein coding gene	Chr1:69032067-69049602 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210032378	protein coding gene	Chr1:72701545-72702811 (+)
CBA/J	ENSMUSGG00210054932	protein coding gene	Chr1:72704372-72707025 (+)
DBA/2J	ENSMUSGG00185057695	protein coding gene	Chr1:73793320-73795973 (+)
DBA/2J	ENSMUSG00185031031	protein coding gene	Chr1:73790493-73791759 (+)
FVB/NJ	ENSMUSGG00205054252	protein coding gene	Chr1:72376370-72379023 (+)
FVB/NJ	ENSMUSG00205026473	protein coding gene	Chr1:72373543-72374809 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230009235	protein coding gene	Chr1:73780467-73781733 (+)
LP/J	ENSMUSGG00230055577	protein coding gene	Chr1:73783294-73785947 (+)
NOD/ShiLtJ	ENSMUSG00190037427	protein coding gene	Chr1:72926973-72928239 (+)
NOD/ShiLtJ	ENSMUSGG00190055054	protein coding gene	Chr1:72929800-72932453 (+)
NZO/HlLtJ	ENSMUSGG00225055253	protein coding gene	Chr1:76998038-77000691 (+)
NZO/HlLtJ	ENSMUSG00225038491	protein coding gene	Chr1:76995211-76996477 (+)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010019521	protein coding gene	Chr1:74353042-74368973 (+)
WSB/EiJ	no annotation

Human Ortholog

SLC4A3, solute carrier family 4 member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC4A3, solute carrier family 4 member 3
Synonyms

AE3, CAE3/BAE3, SLC2C, SQT7
Links

HGNC:11029

NCBI Gene ID: 6508

UniProt: P48751
Chr Location

2q35; chr2:219627011-219641980 (+) GRCh38

MGI Vertebrate Homology

Slc4a3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC4A3
Gene Tree

Slc4a3

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References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotypes from multigenic genotypes
1 images
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

2
Spontaneous

1
Targeted

3
Genomic Mutations

4 involving Slc4a3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for one knock-out allele show inner retina defects including selective ERG b-wave depression, optic nerve and retinal vessel anomalies, sheathing of retinal vessels and late onset photoreceptor death. Homozygotes for another knock-out allele are more sensitive to seizure-inducing agents.

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All GO Annotations

36
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

868
Tissues

122
cDNA Data

66
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc4a3

ZFIN slc4a3

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All Sequences

102
RefSeq

32
UniProt

11
CCDS

CCDS15080.1

Ensembl

ENSMUSG00000006576 (Evidence)
NCBI Gene

20536

			Length	Strain/Species	Flank
genomic	20536	NCBI Gene Model \| MGI Sequence Detail	13388	C57BL/6J	± kb
transcript	NM_009208	RefSeq \| MGI Sequence Detail	4441	ZRU/MplStud
polypeptide	P16283	UniProt \| EBI \| MGI Sequence Detail	1227	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000015159 anion exchange protein 3

(term hierarchy)
InterPro Domains

IPR018241 Anion exchange, conserved site

IPR001717 Anion exchange protein

IPR002979 Anion exchange protein 3

IPR013769 Band 3 cytoplasmic domain

IPR003020 Bicarbonate transporter, eukaryotic

IPR011531 Bicarbonate transporter-like, transmembrane domain

IPR016152 Phosphotransferase/anion transporter
GlyGen

P16283 2 sites, 1 N-linked glycan (1 site)

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All nucleic 71

Genomic 3

cDNA 67

Primer pair 1

Antibodies 1

Microarray probesets 4

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MGD-MRK-1169, MGD-MRK-38395, MGI:1925074

Summaries

All 75

Developmental Gene Expression 5

Diseases 1

Gene Ontology 10

Phenotypes 33
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:358138 Morikawa R, et al., The sodium-bicarbonate cotransporter Slc4a5 mediates feedback at the first synapse of vision. Neuron. 2024 Sep 18;

TSS for Slc4a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7554	Chr1:75522701-75522739 (+)	32 bp
Tssr7555	Chr1:75522902-75522956 (+)	241 bp
Tssr7556	Chr1:75523093-75523158 (+)	438 bp
Tssr7557	Chr1:75523166-75523185 (+)	488 bp
Tssr7558	Chr1:75523284-75523298 (+)	603 bp
Tssr7559	Chr1:75526225-75526270 (+)	3,560 bp
Tssr7560	Chr1:75526375-75526392 (+)	3,696 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24