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Eya3 Gene Detail
Summary
  • Symbol
    Eya3
  • Name
    EYA transcriptional coactivator and phosphatase 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:109339
    NCBI Gene: 14050
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:132366303-132452076 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 65.68 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    836 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109339
 protein coding gene Chr4:132366298-132452076 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028876
 protein coding gene Chr4:134817359-134908217 (+)
A/J MGP_AJ_G0028835
 protein coding gene Chr4:129204584-129289777 (+)
AKR/J MGP_AKRJ_G0028788
 protein coding gene Chr4:132843717-132932719 (+)
BALB/cJ MGP_BALBcJ_G0028858
 protein coding gene Chr4:129824922-129907998 (+)
C3H/HeJ MGP_C3HHeJ_G0028572
 protein coding gene Chr4:133109513-133195357 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029300
 protein coding gene Chr4:139686195-139779254 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026571
 protein coding gene Chr4:122280599-122364822 (+)
CAST/EiJ MGP_CASTEiJ_G0028005
 protein coding gene Chr4:131180835-131262113 (+)
CBA/J MGP_CBAJ_G0028538
 protein coding gene Chr4:143270001-143358082 (+)
DBA/2J MGP_DBA2J_G0028687
 protein coding gene Chr4:129624764-129707426 (+)
FVB/NJ MGP_FVBNJ_G0028654
 protein coding gene Chr4:128485976-128568445 (+)
LP/J MGP_LPJ_G0028788
 protein coding gene Chr4:134970354-135056782 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028680
 protein coding gene Chr4:147846637-147950792 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029338
 protein coding gene Chr4:133263863-133352259 (+)
PWK/PhJ MGP_PWKPhJ_G0027726
 protein coding gene Chr4:126321318-126405721 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027552
 protein coding gene Chr4:129105372-129193705 (+)
WSB/EiJ MGP_WSBEiJ_G0028085
 protein coding gene Chr4:133433181-133518600 (+)



Homology
more
  • Human Ortholog
    EYA3, EYA transcriptional coactivator and phosphatase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EYA3, EYA transcriptional coactivator and phosphatase 3
  • Links
    NCBI Gene ID: 2140
    neXtProt AC: NX_Q99504
    UniProt: Q99504

  • Chr Location
    1p35.3; chr1:27970344-28088637 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit abnormal heart function, decreased grip strength and increased exploratory behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    865
  • Tissues
    109
  • cDNA Data
    124
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14050 NCBI Gene Model | MGI Sequence Detail 85774 C57BL/6J ±  kb
    transcript NM_001403758 RefSeq | MGI Sequence Detail 5325 ZRU/MplStud  
    polypeptide P97480 UniProt | EBI | MGI Sequence Detail 510 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 137
      cDNA 126
      Primer pair 9
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-38384, MGI:2140374
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 10
      Gene Ontology 10
      Phenotypes 15
    • Earliest
      J:38379 Xu PX, et al., Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode. Development. 1997 Jan;124(1):219-31
    • Latest
      J:279462 Wang Y, et al., The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension. Nat Commun. 2019 Sep 12;10(1):4143
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory