Spam1 MGI Mouse Gene Detail - MGI:109335 - sperm adhesion molecule 1

Symbol

Spam1
Name

sperm adhesion molecule 1
Synonyms

Ph-20

Feature Type

protein coding gene
IDs

MGI:109335
NCBI Gene: 20690
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr6:24791187-24801047 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 11.28 cM, cytoband A2
Mapping Data

6 experiments

SNPs within 2kb

293 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109335	protein coding gene	Chr6:24791187-24801047 (+)
129S1/SvImJ	ENSMUSG00200035063	protein coding gene	Chr6:21843312-21853208 (+)
A/J	ENSMUSG00195007764	protein coding gene	Chr6:21785047-21794907 (+)
AKR/J	ENSMUSG00220003114	protein coding gene	Chr6:21355197-21365057 (+)
BALB/cJ	ENSMUSG00180022081	protein coding gene	Chr6:21916052-21925906 (+)
C3H/HeJ	ENSMUSG00175017309	protein coding gene	Chr6:21774419-21784315 (+)
C57BL/6NJ	ENSMUSG00215022748	protein coding gene	Chr6:21859734-21869594 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028148	protein coding gene	Chr6:19874143-19884608 (+)
CAST/EiJ	ENSTCUG00005024332	protein coding gene	Chr6:21465013-21474871 (+)
CBA/J	ENSMUSG00210003407	protein coding gene	Chr6:21792743-21802639 (+)
DBA/2J	ENSMUSG00185020619	protein coding gene	Chr6:21895876-21905748 (+)
FVB/NJ	ENSMUSG00205022766	protein coding gene	Chr6:21865621-21875517 (+)
JF1/MsJ	ENSUMUG00000020833	protein coding gene	Chr6:21627461-21637352 (+)
LP/J	ENSMUSG00230029607	protein coding gene	Chr6:22860257-22870165 (+)
NOD/ShiLtJ	ENSMUSG00190023521	protein coding gene	Chr6:21647417-21657271 (+)
NZO/HlLtJ	ENSMUSG00225014248	protein coding gene	Chr6:24800689-24810549 (+)
PWK/PhJ	ENSLUMG00010022037	protein coding gene	Chr6:21404356-21414365 (+)
SPRET/EiJ	ENSMSPG00010021554	protein coding gene	Chr6:21746625-21752057 (+)
WSB/EiJ	ENSIUOG00005029918	protein coding gene	Chr6:21915997-21925851 (+)

Human Ortholog

SPAM1, sperm adhesion molecule 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPAM1, sperm adhesion molecule 1
Synonyms

HEL-S-96n, HYA1, HYAL5, PH-20, PH20, SPAG15
Links

HGNC:11217

NCBI Gene ID: 6677

UniProt: P38567
Chr Location

7q31.32; chr7:123925237-123971414 (+) GRCh38

MGI Vertebrate Homology

Spam1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SPAM1
Protein SuperFamily

Hyaluronidase
Gene Tree

Spam1

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Phenotype Summary

2 phenotypes from 1 allele in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

5
Targeted

2
Genomic Mutations

1 involving Spam1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available

Male homozygotes for a targeted null mutation are normally fertile, but in vitro their sperm are slower at clearing cells from the cumulus mass.

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All GO Annotations

17
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

691
Tissues

94
cDNA Data

4
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase spam1

ZFIN spam1

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All Sequences

42
RefSeq

6
UniProt

2
CCDS

CCDS19947.1

Ensembl

ENSMUSG00000029682 (Evidence)
NCBI Gene

20690

			Length	Strain/Species	Flank
genomic	20690	NCBI Gene Model \| MGI Sequence Detail	9861	C57BL/6J	± kb
transcript	NM_001079875	RefSeq \| MGI Sequence Detail	2113	ZRU/MplStud
polypeptide	P48794	UniProt \| EBI \| MGI Sequence Detail	512	Not Applicable

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UniProt

2 Sequences
EC

3.2.1.35
InterPro Domains

IPR013785 Aldolase-type TIM barrel

IPR017853 Glycoside hydrolase superfamily

IPR018155 Hyaluronidase

IPR001439 Hyaluronidase PH20/Hyaluronidase-5
GlyGen

P48794 4 sites

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All nucleic 7

Genomic 2

cDNA 5

Microarray probesets 3

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MGD-MRK-38380, MGI:2141611

Summaries

All 43

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 11
Earliest

J:38913 Deng X, et al., The mouse Spam1 maps to proximal chromosome 6 and is a candidate for the sperm dysfunction in Rb(6.16)24Lub and Rb(6.15)1Ald heterozygotes. Mamm Genome. 1997 Feb;8(2):94-7
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Spam1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55179	Chr6:24791174-24791205 (+)	3 bp
Tssr55180	Chr6:24791214-24791222 (+)	31 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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