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Pkp4 Gene Detail
Summary
  • Symbol
    Pkp4
  • Name
    plakophilin 4
  • Synonyms
    5031422I09Rik, 9430019K17Rik, Armrp, p0071
  • Feature Type
    protein coding gene
  • IDs
    MGI:109281
    NCBI Gene: 227937
  • Alliance
    genome feature page
  • Transcription Start Sites
    17 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:58991194-59185552 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 33.52 cM, cytoband C3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5034 from dbSNP Build 142
  • Strain Annotations
    26
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109281
 protein coding gene Chr2:58991123-59185552 (+)
129S1/SvImJ ENSMUSG00200002324
 protein coding gene Chr2:56203699-56250820 (+)
129S1/SvImJ ENSMUSGG00200054846
 protein coding gene Chr2:56109551-56204166 (+)
A/J ENSMUSG00195005101
 protein coding gene Chr2:56324458-56371576 (+)
A/J ENSMUSGG00195055231
 protein coding gene Chr2:56230331-56324925 (+)
AKR/J ENSMUSGG00220054350
 protein coding gene Chr2:56332256-56426850 (+)
AKR/J ENSMUSG00220007214
 protein coding gene Chr2:56426383-56473501 (+)
BALB/cJ ENSMUSGG00180055278
 protein coding gene Chr2:56186587-56281183 (+)
BALB/cJ ENSMUSG00180018873
 protein coding gene Chr2:56280716-56327833 (+)
C3H/HeJ ENSMUSGG00175054880
 protein coding gene Chr2:56255216-56349808 (+)
C3H/HeJ ENSMUSG00175013019
 protein coding gene Chr2:56349341-56396458 (+)
C57BL/6NJ ENSMUSGG00215055500
 protein coding gene Chr2:56240014-56334606 (+)
C57BL/6NJ ENSMUSG00215006296
 protein coding gene Chr2:56334139-56381258 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023576
 protein coding gene Chr2:53994419-54201831 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210055055
 protein coding gene Chr2:56274614-56369206 (+)
CBA/J ENSMUSG00210032293
 protein coding gene Chr2:56368739-56415857 (+)
DBA/2J ENSMUSG00185007723
 protein coding gene Chr2:56224729-56271845 (+)
DBA/2J ENSMUSGG00185057330
 protein coding gene Chr2:56130605-56225196 (+)
FVB/NJ ENSMUSGG00205054512
 protein coding gene Chr2:55771440-55866039 (+)
FVB/NJ ENSMUSG00205019235
 protein coding gene Chr2:55865572-55912679 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055798
 protein coding gene Chr2:57993350-58087960 (+)
LP/J ENSMUSG00230001516
 protein coding gene Chr2:58087493-58134610 (+)
NOD/ShiLtJ ENSMUSG00190043440
 protein coding gene Chr2:56309829-56356947 (+)
NOD/ShiLtJ ENSMUSGG00190054921
 protein coding gene Chr2:56215701-56310296 (+)
NZO/HlLtJ ENSMUSGG00225055511
 protein coding gene Chr2:65719149-65814185 (+)
NZO/HlLtJ ENSMUSG00225000840
 protein coding gene Chr2:65813718-65860746 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PKP4, plakophilin 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PKP4, plakophilin 4
  • Synonyms
    p0071
  • Links
    NCBI Gene ID: 8502
    UniProt: Q99569

  • Chr Location
    2q24.1; chr2:158456900-158682879 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
An uncharacterized gene trap insertion does not result in an obvious phenotype during the observation period early in life, although abnormalities may still develop at older age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    639
  • Tissues
    35
  • cDNA Data
    195
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026991 Ensembl Gene Model | MGI Sequence Detail 194359 C57BL/6J ±  kb
    transcript ENSMUST00000102754 Ensembl | MGI Sequence Detail 4614 Not Applicable  
    polypeptide ENSMUSP00000099815 Ensembl | MGI Sequence Detail 1190 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 197
      cDNA 197

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38326, MGI:1915006, MGI:2442314
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 21
    • Earliest
      J:36767 Hatzfeld M, et al., Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins. J Cell Sci. 1996 Nov;109(Pt 11):2767-78
    • Latest
      J:354293 Muller L, et al., A feedback loop between plakophilin 4 and YAP signaling regulates keratinocyte differentiation. iScience. 2024 Sep 20;27(9):110762
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory