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Pik3r3 Gene Detail
Summary
  • Symbol
    Pik3r3
  • Name
    phosphoinositide-3-kinase regulatory subunit 3
  • Synonyms
    p55, p55pik
  • Feature Type
    protein coding gene
  • IDs
    MGI:109277
    NCBI Gene: 18710
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:116078815-116160253 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1761 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109277
 protein coding gene Chr4:116078593-116160253 (+)
129S1/SvImJ ENSMUSG00200047091
 protein coding gene Chr4:109974269-110055707 (+)
A/J ENSMUSG00195044418
 protein coding gene Chr4:111245022-111327232 (+)
AKR/J ENSMUSG00220010488
 protein coding gene Chr4:110586270-110667696 (+)
BALB/cJ ENSMUSG00180043816
 protein coding gene Chr4:109318337-109399743 (+)
C3H/HeJ ENSMUSG00175038119
 protein coding gene Chr4:110332746-110414208 (+)
C57BL/6NJ ENSMUSG00215029708
 protein coding gene Chr4:111402162-111483603 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026330
 protein coding gene Chr4:106663489-106744318 (+)
CAST/EiJ ENSTCUG00005019202
 protein coding gene Chr4:110101418-110182235 (+)
CBA/J ENSMUSG00210052658
 protein coding gene Chr4:109946246-110027676 (+)
DBA/2J ENSMUSG00185046539
 protein coding gene Chr4:111470746-111552927 (+)
FVB/NJ ENSMUSG00205035412
 protein coding gene Chr4:109415825-109497264 (+)
JF1/MsJ ENSUMUG00000017445
 protein coding gene Chr4:111364185-111445094 (+)
LP/J ENSMUSG00230045135
 protein coding gene Chr4:114791592-114873028 (+)
NOD/ShiLtJ ENSMUSG00190032111
 protein coding gene Chr4:109314620-109396057 (+)
NZO/HlLtJ ENSMUSG00225009535
 protein coding gene Chr4:120278321-120359738 (+)
PWK/PhJ ENSLUMG00010042856
 protein coding gene Chr4:108771591-108854640 (+)
SPRET/EiJ ENSMSPG00010022711
 protein coding gene Chr4:110841034-110933310 (+)
WSB/EiJ ENSIUOG00005038622
 protein coding gene Chr4:109633738-109715084 (+)



Homology
more
  • Human Ortholog
    PIK3R3, phosphoinositide-3-kinase regulatory subunit 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIK3R3, phosphoinositide-3-kinase regulatory subunit 3
  • Synonyms
    p55, p55-GAMMA, p55PIK
  • Links
    NCBI Gene ID: 8503
    UniProt: Q92569

  • Chr Location
    1p34.1; chr1:46040140-46174901 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PIK3R3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    133
  • cDNA Data
    111
  • Literature Summary
    12
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028698 Ensembl Gene Model | MGI Sequence Detail 81439 C57BL/6J ±  kb
transcript ENSMUST00000030464 Ensembl | MGI Sequence Detail 5257 Not Applicable  
polypeptide ENSMUSP00000030464 Ensembl | MGI Sequence Detail 461 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
Molecular
Reagents
less
  • All nucleic 116
    cDNA 114
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-38322, MGI:2140152
References
more
  • Summaries
    All 55
    Developmental Gene Expression 12
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:20946 Venkitaraman AR, et al., Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor. Eur J Immunol. 1994 Sep;24(9):2168-74
  • Latest
    J:345099 Wang X, et al., Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development. BMC Genomics. 2024 Feb 3;25(1):139
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory