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Inhbe Gene Detail
Summary
  • Symbol
    Inhbe
  • Name
    inhibin beta-E
  • Synonyms
    activin beta-E, activin betaE
  • Feature Type
    protein coding gene
  • IDs
    MGI:109269
    NCBI Gene: 16326
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127185271-127187717 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109269
 protein coding gene Chr10:127184726-127190280 (-)
129S1/SvImJ ENSMUSG00200009540
 protein coding gene Chr10:123537702-123543253 (-)
A/J ENSMUSG00195016387
 protein coding gene Chr10:124001738-124007280 (-)
AKR/J ENSMUSG00220004896
 protein coding gene Chr10:123606324-123611875 (-)
BALB/cJ ENSMUSG00180011216
 protein coding gene Chr10:123992803-123998348 (-)
C3H/HeJ ENSMUSG00175005670
 protein coding gene Chr10:123991831-123997369 (-)
C57BL/6NJ ENSMUSG00215015552
 protein coding gene Chr10:123602913-123608467 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015894
 protein coding gene Chr10:119699566-119701913 (-)
CAST/EiJ ENSTCUG00005041232
 protein coding gene Chr10:122975533-122981087 (-)
CBA/J ENSMUSG00210008028
 protein coding gene Chr10:123816019-123821557 (-)
DBA/2J ENSMUSG00185024236
 protein coding gene Chr10:123967841-123973379 (-)
FVB/NJ ENSMUSG00205011564
 protein coding gene Chr10:123212366-123217911 (-)
JF1/MsJ ENSUMUG00000033730
 protein coding gene Chr10:125263260-125268863 (-)
LP/J ENSMUSG00230027953
 protein coding gene Chr10:125885014-125890560 (-)
NOD/ShiLtJ ENSMUSG00190015156
 protein coding gene Chr10:124034792-124040337 (-)
NZO/HlLtJ ENSMUSG00225035921
 protein coding gene Chr10:130085585-130091139 (-)
PWK/PhJ ENSLUMG00010008683
 protein coding gene Chr10:123723411-123728984 (-)
SPRET/EiJ ENSMSPG00010034696
 protein coding gene Chr10:125676487-125680479 (-)
WSB/EiJ ENSIUOG00005006876
 protein coding gene Chr10:123602107-123607655 (-)



Homology
more
  • Human Ortholog
    INHBE, inhibin subunit beta E
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INHBE, inhibin subunit beta E
  • Links
    NCBI Gene ID: 83729
    UniProt: P58166

  • Chr Location
    12q13.3; chr12:57452323-57459280 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Mice homozygous for a null mutation are fertile with normal liver and reproductive morphology and physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • Tissues
    27
  • cDNA Data
    6
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16326 NCBI Gene Model | MGI Sequence Detail 2447 C57BL/6J ±  kb
transcript NM_008382 RefSeq | MGI Sequence Detail 2211 ZRU/MplStud  
polypeptide O08717 UniProt | EBI | MGI Sequence Detail 350 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    Genomic 4
    cDNA 6
    Primer pair 3
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38314
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:16240 Lu RZ, et al., Developmental expression of activin/inhibin beta A, beta B, and alpha subunits, and activin receptor-IIB genes in preimplantation mouse embryos. Biol Reprod. 1993 Dec;49(6):1163-9
  • Latest
    J:362020 Adam RC, et al., Activin E-ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2309967120
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory