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Vasp Gene Detail
Summary
  • Symbol
    Vasp
  • Name
    vasodilator-stimulated phosphoprotein
  • Feature Type
    protein coding gene
  • IDs
    MGI:109268
    NCBI Gene: 22323
  • Alliance
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:18990854-19005742 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.51 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109268
protein coding gene Chr7:18990854-19005779 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031767
protein coding gene Chr7:17233069-17256002 (-)
A/J MGP_AJ_G0031743
protein coding gene Chr7:16899947-16914859 (-)
AKR/J MGP_AKRJ_G0031669
protein coding gene Chr7:17361094-17376011 (-)
BALB/cJ MGP_BALBcJ_G0031748
protein coding gene Chr7:17100727-17116991 (-)
C3H/HeJ MGP_C3HHeJ_G0031470
protein coding gene Chr7:17626438-17641618 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032214
protein coding gene Chr7:18110964-18127302 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029280
protein coding gene Chr7:18545985-18561211 (-)
CAST/EiJ MGP_CASTEiJ_G0030813
protein coding gene Chr7:14031065-14046980 (-)
CBA/J MGP_CBAJ_G0031432
protein coding gene Chr7:18780624-18795482 (-)
DBA/2J MGP_DBA2J_G0031587
protein coding gene Chr7:16839256-16855416 (-)
FVB/NJ MGP_FVBNJ_G0031539
protein coding gene Chr7:16700368-16717317 (-)
LP/J MGP_LPJ_G0031670
protein coding gene Chr7:17566808-17581560 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031575
protein coding gene Chr7:18630330-18648055 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032242
protein coding gene Chr7:16967964-16984160 (-)
PWK/PhJ MGP_PWKPhJ_G0030537
protein coding gene Chr7:13927047-13943462 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030364
protein coding gene Chr7:11683150-11698086 (-)
WSB/EiJ MGP_WSBEiJ_G0030913
protein coding gene Chr7:17181993-17202520 (-)



Homology
more
  • Human Ortholog
    VASP, vasodilator stimulated phosphoprotein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VASP, vasodilator stimulated phosphoprotein
  • Links
    NCBI Gene ID: 7408
    neXtProt AC: NX_P50552
    UniProt: P50552

  • Chr Location
    19q13.32; chr19:45506579-45526989 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit hyperplasia of megakaryocytes, and mutant platelets activated by thrombin display two-fold higher surface expression of P-selectin and fibrinogen binding.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030403 Ensembl Gene Model | MGI Sequence Detail 14889 C57BL/6J ±  kb
transcript ENSMUST00000032561 Ensembl | MGI Sequence Detail 2215 Not Applicable  
polypeptide ENSMUSP00000032561 Ensembl | MGI Sequence Detail 375 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 128
    Genomic 1
    cDNA 127

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-38313, MGI:3034831
References
more
  • Summaries
    All 101
    Developmental Gene Expression 9
    Gene Ontology 10
    Phenotypes 44
  • Earliest
    J:35442 Zimmer M, et al., Cloning of the VASP (vasodilator-stimulated phosphoprotein) genes in human and mouse: structure, sequence, and chromosomal localization. Genomics. 1996 Sep 1;36(2):227-33
  • Latest
    J:327527 Waldman MM, et al., Ena/VASP Protein-Mediated Actin Polymerization Contributes to Naive CD8(+) T Cell Activation and Expansion by Promoting T Cell-APC Interactions In Vivo. Front Immunol. 2022;13:856977

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory