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Gzme Gene Detail
Summary
  • Symbol
    Gzme
  • Name
    granzyme E
  • Synonyms
    CCP3, Ctla-6, Ctla6, MCSP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109265
    NCBI Gene: 14942
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56355083-56358082 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    270 from dbSNP Build 142
  • Strain Annotations
    16
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109265
 protein coding gene Chr14:56355076-56358082 (-)
129S1/SvImJ ENSMUSG00200041252
 protein coding gene Chr14:44942862-44945861 (-)
A/J ENSMUSG00195029932
 protein coding gene Chr14:45159617-45162618 (-)
AKR/J ENSMUSG00220026451
 protein coding gene Chr14:44487477-44490476 (-)
BALB/cJ ENSMUSG00180051148
 protein coding gene Chr14:44783296-44786297 (-)
C3H/HeJ ENSMUSG00175048267
 protein coding gene Chr14:46465615-46468614 (-)
C57BL/6NJ ENSMUSG00215048259
 protein coding gene Chr14:44678368-44681365 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019329
 protein coding gene Chr14:47404466-47407511 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210040913
 protein coding gene Chr14:45146174-45149171 (-)
DBA/2J ENSMUSG00185051728
 protein coding gene Chr14:50267464-50270453 (-)
FVB/NJ ENSMUSG00205037208
 protein coding gene Chr14:44548991-44551992 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230052542
 protein coding gene Chr14:62308701-62311700 (-)
NOD/ShiLtJ ENSMUSG00190039830
 protein coding gene Chr14:44912335-44915334 (-)
NZO/HlLtJ ENSMUSG00225045919
 protein coding gene Chr14:52599065-52602064 (-)
PWK/PhJ ENSLUMG00010039364
 protein coding gene Chr14:44368790-44371791 (-)
SPRET/EiJ ENSMSPG00010046180
 protein coding gene Chr14:47869613-47872597 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GZMB, granzyme B
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GZMB, granzyme B
  • Synonyms
    C11, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
  • Links
    NCBI Gene ID: 3002
    UniProt: P10144

  • Chr Location
    14q12; chr14:24630954-24634267 (-)  GRCh38
  • Human Ortholog
    GZMH, granzyme H
  • Synonyms
    CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2
  • Links
    NCBI Gene ID: 2999
    UniProt: P20718

  • Chr Location
    14q12; chr14:24606480-24609821 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    607
  • Tissues
    4
  • cDNA Data
    10
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022156 Ensembl Gene Model | MGI Sequence Detail 3000 C57BL/6J ±  kb
transcript ENSMUST00000089549 Ensembl | MGI Sequence Detail 916 Not Applicable  
polypeptide ENSMUSP00000086978 Ensembl | MGI Sequence Detail 248 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    Genomic 8
    cDNA 10
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-2226, MGD-MRK-2236, MGD-MRK-38310
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:39247 Masson D, et al., A family of serine esterases in lytic granules of cytolytic T lymphocytes. Cell. 1987 Jun 5;49(5):679-85
  • Latest
    J:378075 Fan H, et al., Partial embryo loss caused by disruption of the placental hormone CTRP6 coincides with dNK cell abnormalities during pregnancy. iScience. 2026 Jan 16;29(1):114434
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory