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Gzmd Gene Detail
Summary
  • Symbol
    Gzmd
  • Name
    granzyme D
  • Synonyms
    CCP5, Ctla-5, Ctla5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109255
    NCBI Gene: 14941
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56367013-56370060 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    265 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109255
 protein coding gene Chr14:56367013-56370065 (-)
129S1/SvImJ ENSMUSG00200041258
 protein coding gene Chr14:44954792-44957844 (-)
A/J ENSMUSG00195029955
 protein coding gene Chr14:45171549-45174601 (-)
AKR/J ENSMUSG00220026469
 protein coding gene Chr14:44499409-44502461 (-)
BALB/cJ ENSMUSG00180051158
 protein coding gene Chr14:44795230-44798282 (-)
C3H/HeJ ENSMUSG00175048294
 protein coding gene Chr14:46477545-46480597 (-)
C57BL/6NJ ENSMUSG00215048263
 protein coding gene Chr14:44690296-44693348 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019330
 protein coding gene Chr14:47426024-47429089 (-)
CAST/EiJ ENSTCUG00005046118
 protein coding gene Chr14:46471294-46474361 (-)
CBA/J ENSMUSG00210040943
 protein coding gene Chr14:45158100-45161152 (-)
DBA/2J ENSMUSG00185049292
 protein coding gene Chr14:50279326-50282399 (-)
FVB/NJ ENSMUSG00205037252
 protein coding gene Chr14:44560924-44563976 (-)
JF1/MsJ ENSUMUG00000040233
 protein coding gene Chr14:61457161-61460241 (-)
LP/J ENSMUSG00230052547
 protein coding gene Chr14:62320631-62323683 (-)
NOD/ShiLtJ ENSMUSG00190039889
 protein coding gene Chr14:44924264-44927316 (-)
NZO/HlLtJ ENSMUSG00225045927
 protein coding gene Chr14:52610995-52614047 (-)
PWK/PhJ ENSLUMG00010039414
 protein coding gene Chr14:44380722-44383774 (-)
SPRET/EiJ ENSMSPG00010046194
 protein coding gene Chr14:47881464-47884531 (-)
WSB/EiJ ENSIUOG00005042753
 protein coding gene Chr14:44356066-44359133 (-)



Homology
more
  • Human Ortholog
    GZMB, granzyme B
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GZMB, granzyme B
  • Synonyms
    C11, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
  • Links
    NCBI Gene ID: 3002
    UniProt: P10144

  • Chr Location
    14q12; chr14:24630954-24634267 (-)  GRCh38
  • Human Ortholog
    GZMH, granzyme H
  • Synonyms
    CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2
  • Links
    NCBI Gene ID: 2999
    UniProt: P20718

  • Chr Location
    14q12; chr14:24606480-24609821 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    2
  • cDNA Data
    15
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14941 NCBI Gene Model | MGI Sequence Detail 3048 C57BL/6J ±  kb
transcript NM_010372 RefSeq | MGI Sequence Detail 937 ZRU/MplStud  
polypeptide P11033 UniProt | EBI | MGI Sequence Detail 252 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    Genomic 11
    cDNA 15
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-2235, MGD-MRK-38300
References
more
  • Summaries
    All 42
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:8216 Lobe CG, et al., Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1448-52
  • Latest
    J:378075 Fan H, et al., Partial embryo loss caused by disruption of the placental hormone CTRP6 coincides with dNK cell abnormalities during pregnancy. iScience. 2026 Jan 16;29(1):114434
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory