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Sem1 Gene Detail
Summary
  • Symbol
    Sem1
  • Name
    SEM1, 26S proteasome complex subunit
  • Synonyms
    DSS1, Shfdg1, Shfg, Shfm1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109238
    NCBI Gene: 20422
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:6558275-6578658 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 2.59 cM, cytoband A2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    256 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109238
 protein coding gene Chr6:6557294-6578663 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030439
 protein coding gene Chr6:3469106-3494932 (-)
A/J MGP_AJ_G0030412
 protein coding gene Chr6:3331258-3352714 (-)
AKR/J MGP_AKRJ_G0030339
 protein coding gene Chr6:3428411-3453672 (-)
BALB/cJ MGP_BALBcJ_G0030421
 protein coding gene Chr6:3281240-3303018 (-)
C3H/HeJ MGP_C3HHeJ_G0030135
 protein coding gene Chr6:3391646-3413092 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030876
 protein coding gene Chr6:3552156-3573513 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028087
 protein coding gene Chr6:2969533-2995866 (-)
CAST/EiJ MGP_CASTEiJ_G0029536
 protein coding gene Chr6:3388758-3410248 (-)
CBA/J MGP_CBAJ_G0030113
 protein coding gene Chr6:3714950-3736404 (-)
DBA/2J MGP_DBA2J_G0030257
 protein coding gene Chr6:3274456-3295773 (-)
FVB/NJ MGP_FVBNJ_G0030211
 protein coding gene Chr6:3255886-3277342 (-)
LP/J MGP_LPJ_G0030344
 protein coding gene Chr6:3415108-3441278 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030247
 protein coding gene Chr6:3730143-3756517 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030906
 protein coding gene Chr6:3383509-3410624 (-)
PWK/PhJ MGP_PWKPhJ_G0029251
 protein coding gene Chr6:3215241-3236957 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029087
 protein coding gene Chr6:3433934-3454314 (-)
WSB/EiJ MGP_WSBEiJ_G0029613
 protein coding gene Chr6:3365821-3388761 (-)



Homology
more
  • Human Ortholog
    SEM1, SEM1 26S proteasome subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEM1, SEM1 26S proteasome subunit
  • Synonyms
    C7orf76, DSS1, ECD, PSMD15, SHFD1, Shfdg1, SHFM1, SHSF1
  • Links
    NCBI Gene ID: 7979
    neXtProt AC: NX_P60896
    UniProt: P60896

  • Chr Location
    7q21.3; chr7:96481626-96709880 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    955
  • Tissues
    167
  • cDNA Data
    81
  • Literature Summary
    11
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20422 NCBI Gene Model | MGI Sequence Detail 20384 C57BL/6J ±  kb
transcript NM_009169 RefSeq | MGI Sequence Detail 491 C57BL/6  
polypeptide P60897 UniProt | EBI | MGI Sequence Detail 70 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 90
    Genomic 1
    cDNA 82
    Primer pair 5
    Other 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-36045, MGD-MRK-38283
References
more
  • Summaries
    All 50
    Developmental Gene Expression 11
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:32927 Crackower MA, et al., Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development. Hum Mol Genet. 1996 May;5(5):571-9
  • Latest
    J:323630 Mishra AP, et al., BRCA2-DSS1 interaction is dispensable for RAD51 recruitment at replication-induced and meiotic DNA double strand breaks. Nat Commun. 2022 Apr 1;13(1):1751
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory