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Efnb3 Gene Detail
Summary
  • Symbol
    Efnb3
  • Name
    ephrin B3
  • Synonyms
    EFL-6, ELF-3, Elk-L3, Epl8, LERK-8, NLERK-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109196
    NCBI Gene: 13643
  • Alliance
  • Transcription Start Sites
    7 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr11:69444918-69451031 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.80 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109196
protein coding gene Chr11:69444918-69452428 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018536
protein coding gene Chr11:69999859-70005971 (-)
A/J MGP_AJ_G0018504
protein coding gene Chr11:67365729-67371839 (-)
AKR/J MGP_AKRJ_G0018473
protein coding gene Chr11:69375473-69381586 (-)
BALB/cJ MGP_BALBcJ_G0018476
protein coding gene Chr11:67677410-67683521 (-)
C3H/HeJ MGP_C3HHeJ_G0018289
protein coding gene Chr11:69396555-69402671 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018927
protein coding gene Chr11:72124601-72130710 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016572
protein coding gene Chr11:64290124-64296266 (-)
CAST/EiJ MGP_CASTEiJ_G0017844
protein coding gene Chr11:69640171-69646287 (-)
CBA/J MGP_CBAJ_G0018262
protein coding gene Chr11:75343618-75349723 (-)
DBA/2J MGP_DBA2J_G0018371
protein coding gene Chr11:66948282-66954399 (-)
FVB/NJ MGP_FVBNJ_G0018361
protein coding gene Chr11:66585728-66591846 (-)
LP/J MGP_LPJ_G0018441
protein coding gene Chr11:70571319-70577434 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018384
protein coding gene Chr11:75948064-75954174 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018969
protein coding gene Chr11:69629741-69635856 (-)
PWK/PhJ MGP_PWKPhJ_G0017618
protein coding gene Chr11:67597060-67603212 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017408
protein coding gene Chr11:69445821-69451945 (-)
WSB/EiJ MGP_WSBEiJ_G0017898
protein coding gene Chr11:69303915-69310030 (-)



Homology
more
  • Human Ortholog
    EFNB3, ephrin B3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EFNB3, ephrin B3
  • Synonyms
    EFL6, EPLG8, LERK8
  • Links
    NCBI Gene ID: 1949
    neXtProt AC: NX_Q15768
    UniProt: Q15768

  • Chr Location
    17p13.1; chr17:7705202-7711372 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with Efnb3 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 10 alleles in 8 genetic backgrounds
    1 images
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations exhibit a hopping gait due to corticospinal tract defects, mutations that remove only the cytoplasmic domain of the protein do not result in the gait or CNS phenotypes, and a G244E mutation causes ataxia
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003934 Ensembl Gene Model | MGI Sequence Detail 6114 C57BL/6J ±  kb
    transcript ENSMUST00000004036 Ensembl | MGI Sequence Detail 3183 Not Applicable  
    polypeptide ENSMUSP00000004036 Ensembl | MGI Sequence Detail 340 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 82
      Genomic 1
      cDNA 73
      Primer pair 4
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38240
    References
    more
    • Summaries
      All 148
      Developmental Gene Expression 76
      Diseases 1
      Gene Ontology 11
      Phenotypes 47
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:344193 Qiao Z, et al., Ephrin B3 exacerbates colitis and colitis-associated colorectal cancer. Biochem Pharmacol. 2023 Dec 22;220:116004

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    04/09/2024
    MGI 6.23
    The Jackson Laboratory