Kcnab1 MGI Mouse Gene Detail - MGI:109155 - potassium voltage-gated channel, shaker-related subfamily, beta member 1

Symbol

Kcnab1
Name

potassium voltage-gated channel, shaker-related subfamily, beta member 1
Synonyms

Akr8a8, Kvbeta1.1, mKv(beta)1

Feature Type

protein coding gene
IDs

MGI:109155
NCBI Gene: 16497
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr3:64856633-65285646 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 30.15 cM
Mapping Data

3 experiments

SNPs within 2kb

2776 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109155	protein coding gene	Chr3:64856617-65285646 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027270	protein coding gene	Chr3:64210072-64490726 (+)
A/J	MGP_AJ_G0027231	protein coding gene	Chr3:62351309-62620387 (+)
AKR/J	MGP_AKRJ_G0027200	protein coding gene	Chr3:63630946-63897261 (+)
BALB/cJ	MGP_BALBcJ_G0027243	protein coding gene	Chr3:62178961-62440430 (+)
C3H/HeJ	MGP_C3HHeJ_G0026987	protein coding gene	Chr3:63910961-64190569 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027689	protein coding gene	Chr3:66642014-66923374 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025042	protein coding gene	Chr3:58746208-59019076 (+)
CAST/EiJ	MGP_CASTEiJ_G0026434	protein coding gene	Chr3:63854151-64134059 (+)
CBA/J	MGP_CBAJ_G0026962	protein coding gene	Chr3:68724869-68995380 (+)
DBA/2J	MGP_DBA2J_G0027098	protein coding gene	Chr3:61842803-62118769 (+)
FVB/NJ	MGP_FVBNJ_G0027066	protein coding gene	Chr3:60500437-60762817 (+)
LP/J	MGP_LPJ_G0027206	protein coding gene	Chr3:65133041-65407759 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027084	protein coding gene	Chr3:73309882-73600621 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027747	protein coding gene	Chr3:63532662-63806209 (+)
PWK/PhJ	MGP_PWKPhJ_G0026168	protein coding gene	Chr3:61599200-61865257 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025984	protein coding gene	Chr3:62731648-63015152 (+)
WSB/EiJ	MGP_WSBEiJ_G0026512	protein coding gene	Chr3:63662113-63937931 (+)

Human Ortholog

KCNAB1, potassium voltage-gated channel subfamily A regulatory beta subunit 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNAB1, potassium voltage-gated channel subfamily A regulatory beta subunit 1
Synonyms

AKR6A3, hKvb3, hKvBeta3, KCNA1B, Kvb1.3, KV-BETA-1
Links

HGNC:6228

NCBI Gene ID: 7881

neXtProt AC: NX_Q14722

UniProt: Q14722
Chr Location

3q25.31; chr3:156118211-156540603 (+) GRCh38.p7

Alliance of Genome Resources

Kcnab1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KCNAB1
Gene Tree

Kcnab1

Diseases

1 with human KCNAB1 associations

				Human Disease	Mouse Models
				temporal lobe epilepsy IDs temporal lobe epilepsy DOID:3328 MESH:D004833 NCI:C177244 OMIM:PS600512 UMLS_CUI:C0014556

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 3 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

5
Transgenic

1
Genomic Mutations

2 involving Kcnab1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene experience some learning defects but are otherwise normal.

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All GO Annotations

47
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

777
Tissues

56
cDNA Data

22
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcnab1

ZFIN kcnab1a, kcnab1b

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Kcnab1 interacts with 305 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

61
RefSeq

10
UniProt

6
CCDS

CCDS38447.1, CCDS89632.1

Ensembl

ENSMUSG00000027827 (Evidence)
NCBI Gene

16497

			Length	Strain/Species	Flank
genomic	16497	NCBI Gene Model \| MGI Sequence Detail	429014	C57BL/6J	± kb
transcript	NM_010597	RefSeq \| MGI Sequence Detail	3597	C57BL/6
polypeptide	P63143	UniProt \| EBI \| MGI Sequence Detail	401	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000009251 voltage-gated potassium channel subunit beta-1

(term hierarchy)
EC

1.1.1.-
InterPro Domains

IPR023210 NADP-dependent oxidoreductase domain

IPR036812 NADP-dependent oxidoreductase domain superfamily

IPR005983 Potassium channel, voltage-dependent, beta subunit, KCNAB

IPR005400 Potassium channel, voltage-dependent, beta subunit, KCNAB1

IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related

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All nucleic 24

cDNA 23

Primer pair 1

Microarray probesets 5

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MGD-MRK-38199

Summaries

All 51

Developmental Gene Expression 9

Diseases 1

Gene Ontology 8

Phenotypes 14
Earliest

J:36040 Fink M, et al., A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression. J Biol Chem. 1996 Oct 18;271(42):26341-8
Latest

J:330917 Ohanyan V, et al., Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvbeta Proteins. Circ Res. 2021 Mar 19;128(6):738-751

TSS for Kcnab1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29384	Chr3:64856632-64856640 (+)	3 bp
Tssr29385	Chr3:64856650-64856664 (+)	24 bp
Tssr29386	Chr3:64856711-64856716 (+)	81 bp
Tssr29387	Chr3:64884904-64884917 (+)	28,278 bp
Tssr29388	Chr3:64884952-64884967 (+)	28,327 bp
Tssr29389	Chr3:64885007-64885018 (+)	28,380 bp
Tssr892	Chr3:65016320-65016332 (+)	159,693 bp
Tssr29390	Chr3:65016389-65016408 (+)	159,766 bp
Tssr29391	Chr3:65016417-65016458 (+)	159,805 bp
Tssr29392	Chr3:65016464-65016510 (+)	159,854 bp
Tssr29393	Chr3:65016690-65016708 (+)	160,066 bp
Tssr29394	Chr3:65016750-65016761 (+)	160,123 bp
Tssr29395	Chr3:65016764-65016841 (+)	160,170 bp
Tssr29396	Chr3:65016892-65016907 (+)	160,267 bp
Tssr29397	Chr3:65016920-65016955 (+)	160,305 bp
Tssr29398	Chr3:65095533-65095564 (+)	238,916 bp
Tssr29399	Chr3:65246960-65246963 (+)	390,329 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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