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Dennd2b Gene Detail
Summary
  • Symbol
    Dennd2b
  • Name
    DENN domain containing 2B
  • Synonyms
    2010004M01Rik, 2610305K15Rik, Denn2b, St5
  • Feature Type
    protein coding gene
  • IDs
    MGI:108517
    NCBI Gene: 76954
  • Alliance
    genome feature page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:109123118-109302812 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 57.27 cM, cytoband F2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4733 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108517
 protein coding gene Chr7:109123118-109302828 (-)
129S1/SvImJ ENSMUSG00200031751
 protein coding gene Chr7:95664704-95844821 (-)
A/J ENSMUSG00195054195
 protein coding gene Chr7:100160924-100340866 (-)
AKR/J ENSMUSG00220037615
 protein coding gene Chr7:93564381-93744332 (-)
BALB/cJ ENSMUSG00180039726
 protein coding gene Chr7:96836103-97016228 (-)
C3H/HeJ ENSMUSG00175047507
 protein coding gene Chr7:97472088-97652196 (-)
C57BL/6NJ ENSMUSG00215047765
 protein coding gene Chr7:96776912-96957038 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030310
 protein coding gene Chr7:111736764-111828240 (-)
CAST/EiJ ENSTCUG00005052305
 protein coding gene Chr7:100148086-100327451 (-)
CBA/J ENSMUSG00210035158
 protein coding gene Chr7:97299233-97479352 (-)
DBA/2J ENSMUSG00185020270
 protein coding gene Chr7:101649498-101829617 (-)
FVB/NJ ENSMUSG00205045191
 protein coding gene Chr7:97261467-97441587 (-)
JF1/MsJ ENSUMUG00000038655
 protein coding gene Chr7:106664153-106843664 (-)
LP/J ENSMUSG00230043799
 protein coding gene Chr7:107750527-107930637 (-)
NOD/ShiLtJ ENSMUSG00190040264
 protein coding gene Chr7:97459900-97638995 (-)
NZO/HlLtJ ENSMUSG00225015646
 protein coding gene Chr7:105968940-106148875 (-)
PWK/PhJ ENSLUMG00010036160
 protein coding gene Chr7:95781904-95961004 (-)
SPRET/EiJ ENSMSPG00010040763
 protein coding gene Chr7:96938812-97122170 (-)
WSB/EiJ ENSIUOG00005046538
 protein coding gene Chr7:98095373-98274759 (-)



Homology
more
  • Human Ortholog
    DENND2B, DENN domain containing 2B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DENND2B, DENN domain containing 2B
  • Synonyms
    HTS1, p126, ST5
  • Links
    NCBI Gene ID: 6764
    UniProt: P78524

  • Chr Location
    11p15.4; chr11:8693343-8910951 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    641
  • Tissues
    22
  • cDNA Data
    11
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031024 Ensembl Gene Model | MGI Sequence Detail 179695 C57BL/6J ±  kb
transcript ENSMUST00000077909 Ensembl | MGI Sequence Detail 4612 Not Applicable  
polypeptide ENSMUSP00000077067 Ensembl | MGI Sequence Detail 1134 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 6
    cDNA 11
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37561, MGI:1919751, MGI:1924204, MGI:6369420, MGI:7382744
References
more
  • Summaries
    All 50
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory