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Prkag1 Gene Detail
Summary
  • Symbol
    Prkag1
  • Name
    protein kinase, AMP-activated, gamma 1 non-catalytic subunit
  • Synonyms
    Prkaac
  • Feature Type
    protein coding gene
  • IDs
    MGI:108411
    NCBI Gene: 19082
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:98710678-98729354 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 54.73 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    416 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108411
protein coding gene Chr15:98710678-98729402 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022313
protein coding gene Chr15:100575381-100595136 (-)
A/J MGP_AJ_G0022271
protein coding gene Chr15:96601268-96621259 (-)
AKR/J MGP_AKRJ_G0022246
protein coding gene Chr15:99575145-99595371 (-)
BALB/cJ MGP_BALBcJ_G0022278
protein coding gene Chr15:96796662-96816767 (-)
C3H/HeJ MGP_C3HHeJ_G0022046
protein coding gene Chr15:99627885-99647192 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022723
protein coding gene Chr15:104320128-104340066 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020248
protein coding gene Chr15:92519545-92536962 (-)
CAST/EiJ MGP_CASTEiJ_G0021569
protein coding gene Chr15:100476982-100497338 (-)
CBA/J MGP_CBAJ_G0022015
protein coding gene Chr15:107861774-107880536 (-)
DBA/2J MGP_DBA2J_G0022141
protein coding gene Chr15:96045717-96069481 (-)
FVB/NJ MGP_FVBNJ_G0022121
protein coding gene Chr15:95025304-95044040 (-)
LP/J MGP_LPJ_G0022213
protein coding gene Chr15:100724398-100744665 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022141
protein coding gene Chr15:111856937-111876785 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022738
protein coding gene Chr15:99657243-99680206 (-)
PWK/PhJ MGP_PWKPhJ_G0021310
protein coding gene Chr15:96168104-96187046 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021145
protein coding gene Chr15:99509168-99532246 (-)
WSB/EiJ MGP_WSBEiJ_G0021619
protein coding gene Chr15:100206831-100225427 (-)



Homology
more
  • Human Ortholog
    PRKAG1, protein kinase AMP-activated non-catalytic subunit gamma 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKAG1, protein kinase AMP-activated non-catalytic subunit gamma 1
  • Synonyms
    AMPKG
  • Links
    NCBI Gene ID: 5571
    neXtProt AC: NX_P54619
    UniProt: P54619

  • Chr Location
    12q13.12; chr12:49002274-49018807 (-)  GRCh38

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 1 allele in 1 genetic background
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hemolytic anemia, extramedullary hematopoiesis, and iron accumulation in the spleen, liver, and Kupffer cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19082 NCBI Gene Model | MGI Sequence Detail 18677 C57BL/6J ±  kb
    transcript NM_001411575 RefSeq | MGI Sequence Detail 1731 ZRU/MplStud  
    polypeptide O54950 UniProt | EBI | MGI Sequence Detail 330 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 117
      cDNA 114
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37454, MGI:2145917, MGI:2146255
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 12
      Phenotypes 32
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:294606 An H, et al., The importance of the AMPK gamma 1 subunit in metformin suppression of liver glucose production. Sci Rep. 2020 Jun 26;10(1):10482

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory