Dtymk MGI Mouse Gene Detail - MGI:108396

Symbol

Dtymk
Name

deoxythymidylate kinase
Synonyms

CDC8, D10Ertd203e, mtmk, Tmk, TYPK

Feature Type

protein coding gene
IDs

MGI:108396
NCBI Gene: 21915
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:93720298-93729656 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 47.34 cM
Mapping Data

2 experiments

SNPs within 2kb

250 from dbSNP Build 142
Strain Annotations

26

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108396	protein coding gene	Chr1:93720298-93730246 (-)
129S1/SvImJ	ENSMUSGG00200054446	protein coding gene	Chr1:90937287-90943699 (-)
129S1/SvImJ	ENSMUSG00200036139	protein coding gene	Chr1:90944763-90946605 (-)
A/J	ENSMUSG00195026577	protein coding gene	Chr1:90503693-90505535 (-)
A/J	ENSMUSGG00195054941	protein coding gene	Chr1:90496217-90502629 (-)
AKR/J	ENSMUSG00220000179	protein coding gene	Chr1:90658797-90660638 (-)
AKR/J	ENSMUSGG00220054696	protein coding gene	Chr1:90651455-90657733 (-)
BALB/cJ	ENSMUSG00180005411	protein coding gene	Chr1:90820906-90822748 (-)
BALB/cJ	ENSMUSGG00180055521	protein coding gene	Chr1:90813430-90819842 (-)
C3H/HeJ	ENSMUSG00175001187	protein coding gene	Chr1:90698597-90700439 (-)
C3H/HeJ	ENSMUSGG00175055014	protein coding gene	Chr1:90691091-90697533 (-)
C57BL/6NJ	ENSMUSG00215031450	protein coding gene	Chr1:90630334-90632175 (-)
C57BL/6NJ	ENSMUSGG00215055785	protein coding gene	Chr1:90622993-90629270 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014463	protein coding gene	Chr1:86265287-86274264 (-)
CAST/EiJ	no annotation
CBA/J	ENSMUSGG00210054529	protein coding gene	Chr1:90536257-90542681 (-)
CBA/J	ENSMUSG00210011843	protein coding gene	Chr1:90543745-90545587 (-)
DBA/2J	ENSMUSGG00185057729	protein coding gene	Chr1:95009548-95015960 (-)
DBA/2J	ENSMUSG00185013883	protein coding gene	Chr1:95017024-95018866 (-)
FVB/NJ	ENSMUSGG00205054588	protein coding gene	Chr1:89945904-89952328 (-)
FVB/NJ	ENSMUSG00205033507	protein coding gene	Chr1:89953392-89955234 (-)
JF1/MsJ	no annotation
LP/J	ENSMUSGG00230055628	protein coding gene	Chr1:94273358-94279770 (-)
LP/J	ENSMUSG00230022485	protein coding gene	Chr1:94280834-94282676 (-)
NOD/ShiLtJ	ENSMUSG00190023392	protein coding gene	Chr1:90588615-90590457 (-)
NOD/ShiLtJ	ENSMUSGG00190054716	protein coding gene	Chr1:90581140-90587551 (-)
NZO/HlLtJ	ENSMUSGG00225055184	protein coding gene	Chr1:98171158-98177552 (-)
NZO/HlLtJ	ENSMUSG00225003185	protein coding gene	Chr1:98178616-98180459 (-)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

DTYMK, deoxythymidylate kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DTYMK, deoxythymidylate kinase
Synonyms

CDC8, CONPM, PP3731, TMPK, TYMK
Links

HGNC:3061

NCBI Gene ID: 1841

UniProt: P23919
Chr Location

2q37.3; chr2:241675742-241686944 (-) GRCh38

MGI Vertebrate Homology

Dtymk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DTYMK
Gene Tree

Dtymk

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

25
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Dtymk
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available

Homozygous mice for a null allele exhibit embryonic lethality before E12.5.

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All GO Annotations

30
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

831
Tissues

106
cDNA Data

116
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dtymk

ZFIN dtymk

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All Sequences

72
RefSeq

5
UniProt

3
CCDS

CCDS35672.1, CCDS48329.1

Ensembl

ENSMUSG00000026281 (Evidence)
NCBI Gene

21915

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026281	Ensembl Gene Model \| MGI Sequence Detail	9359	C57BL/6J	± kb
transcript	ENSMUST00000027503	Ensembl \| MGI Sequence Detail	1003	Not Applicable
polypeptide	ENSMUSP00000027503	Ensembl \| MGI Sequence Detail	212	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006725 thymidylate kinase

(term hierarchy)
EC

2.7.4.9
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR018094 Thymidylate kinase

IPR018095 Thymidylate kinase, conserved site

IPR039430 Thymidylate kinase-like domain

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All nucleic 119

cDNA 118

Primer pair 1

Antibodies 1

Microarray probesets 8

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MGD-MRK-37438, MGI:1261792, MGI:2138504

Summaries

All 51

Developmental Gene Expression 5

Gene Ontology 10

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:347587 Tiani KA, et al., DTYMK is an essential gene in mice and heterozygosity does not cause neural tube defects. Arch Biochem Biophys. 2024 May;755:109991

TSS for Dtymk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13052	Chr1:93729562-93729667 (-)	41 bp
Tssr13051	Chr1:93727080-93727092 (-)	2,570 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29