Vnn1 MGI Mouse Gene Detail - MGI:108395

Symbol

Vnn1
Name

vanin 1
Synonyms

pantetheinase, V-1

Feature Type

protein coding gene
IDs

MGI:108395
NCBI Gene: 22361
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:23770586-23781241 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 11.33 cM, cytoband A1-B2
Mapping Data

4 experiments

SNPs within 2kb

101 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108395	protein coding gene	Chr10:23770586-23781242 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017075	protein coding gene	Chr10:21823914-21835602 (+)
A/J	MGP_AJ_G0017053	protein coding gene	Chr10:21185365-21195943 (+)
AKR/J	MGP_AKRJ_G0017015	protein coding gene	Chr10:21530292-21540866 (+)
BALB/cJ	MGP_BALBcJ_G0017015	protein coding gene	Chr10:21259265-21269794 (+)
C3H/HeJ	MGP_C3HHeJ_G0016835	protein coding gene	Chr10:21735505-21747523 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017473	protein coding gene	Chr10:22466273-22484614 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015174	protein coding gene	Chr10:19915480-19926296 (+)
CAST/EiJ	MGP_CASTEiJ_G0016416	protein coding gene	Chr10:21632029-21642764 (+)
CBA/J	MGP_CBAJ_G0016808	protein coding gene	Chr10:23469331-23484946 (+)
DBA/2J	MGP_DBA2J_G0016914	protein coding gene	Chr10:20922602-20938004 (+)
FVB/NJ	MGP_FVBNJ_G0016910	protein coding gene	Chr10:20640581-20653045 (+)
LP/J	MGP_LPJ_G0016990	protein coding gene	Chr10:21804370-21822941 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016940	protein coding gene	Chr10:23612678-23624719 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017508	protein coding gene	Chr10:21398149-21410980 (+)
PWK/PhJ	MGP_PWKPhJ_G0016201	protein coding gene	Chr10:20664841-20675692 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015983	protein coding gene	Chr10:21210603-21220885 (+)
WSB/EiJ	MGP_WSBEiJ_G0016479	protein coding gene	Chr10:21497826-21509086 (+)

Human Ortholog

VNN1, vanin 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VNN1, vanin 1
Synonyms

HDLCQ8, Tiff66
Links

HGNC:12705

NCBI Gene ID: 8876

neXtProt AC: NX_O95497

UniProt: O95497
Chr Location

6q23.2; chr6:132680849-132714055 (-) GRCh38

MGI Vertebrate Homology

Vnn1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: VNN1
Protein SuperFamily

Biotinidase
Gene Tree

Vnn1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

4
Genomic Mutations

1 involving Vnn1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available

Mice homozygous for disruptions of this gene develop normally and so no abnormalities in the maturation of lymphoid organs. However, membrane bound pantetheinase is absent in livers and kidneys resuulting in an absence of cysteamine in these organs.

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All GO Annotations

22
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

892
Tissues

130
cDNA Data

25
Literature Summary

15

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vnn1

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All Sequences

42
RefSeq

6
UniProt

2
CCDS

CCDS35868.1

Ensembl

ENSMUSG00000037440 (Evidence)
NCBI Gene

22361

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037440	Ensembl Gene Model \| MGI Sequence Detail	10656	C57BL/6J	± kb
transcript	ENSMUST00000041416	Ensembl \| MGI Sequence Detail	2416	Not Applicable
polypeptide	ENSMUSP00000040599	Ensembl \| MGI Sequence Detail	512	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017313 pantetheinase

(term hierarchy)
EC

3.5.1.92
InterPro Domains

IPR012101 Biotinidase-like, eukaryotic

IPR040154 Biotinidase/VNN family

IPR003010 Carbon-nitrogen hydrolase

IPR036526 Carbon-nitrogen hydrolase superfamily

IPR043957 Vanin, C-terminal

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All nucleic 31

Genomic 1

cDNA 26

Primer pair 3

Other 1

Microarray probesets 5

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MGD-MRK-37437

Summaries

All 73

Developmental Gene Expression 15

Gene Ontology 12

Phenotypes 24
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:329881 Chen J, et al., VNN1 contributes to the acute kidney injury-chronic kidney disease transition by promoting cellular senescence via affecting RB1 expression. FASEB J. 2022 Sep;36(9):e22472

TSS for Vnn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92718	Chr10:23770745-23770761 (+)	167 bp
Tssr92719	Chr10:23778044-23778054 (+)	7,463 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23