About   Help   FAQ
Kif4 Gene Detail
Summary
  • Symbol
    Kif4
  • Name
    kinesin family member 4
  • Synonyms
    D330050K22Rik, Kns4, N-5 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:108389
    NCBI Gene: 16571
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:99669693-99770878 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 43.72 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    649 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108389
protein coding gene ChrX:99669343-99770878 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035947
protein coding gene ChrX:97085236-97189558 (+)
A/J MGP_AJ_G0035932
protein coding gene ChrX:97128879-97228660 (+)
AKR/J MGP_AKRJ_G0035848
protein coding gene ChrX:99914181-100014574 (+)
BALB/cJ MGP_BALBcJ_G0035915
protein coding gene ChrX:95873089-95973326 (+)
C3H/HeJ MGP_C3HHeJ_G0035624
protein coding gene ChrX:97517106-97620649 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036444
protein coding gene ChrX:99997654-100104655 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033274
protein coding gene ChrX:94902149-95004665 (+)
CAST/EiJ MGP_CASTEiJ_G0034911
protein coding gene ChrX:81820114-81924286 (+)
CBA/J MGP_CBAJ_G0035599
protein coding gene ChrX:103092132-103200985 (+)
DBA/2J MGP_DBA2J_G0035753
protein coding gene ChrX:96334723-96431884 (+)
FVB/NJ MGP_FVBNJ_G0035691
protein coding gene ChrX:95734297-95831925 (+)
LP/J MGP_LPJ_G0035843
protein coding gene ChrX:98067217-98169476 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035726
protein coding gene ChrX:107622809-107728615 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036471
protein coding gene ChrX:96802015-96907442 (+)
PWK/PhJ MGP_PWKPhJ_G0034610
protein coding gene ChrX:79440313-79542862 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034438
protein coding gene ChrX:82707641-82809144 (+)
WSB/EiJ MGP_WSBEiJ_G0035050
protein coding gene ChrX:95518827-95621441 (+)



Homology
more
  • Human Ortholog
    KIF4A, kinesin family member 4A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIF4A, kinesin family member 4A
  • Synonyms
    KIF4, KIF4G1, MRX100, TMDI, XLID100
  • Links
    NCBI Gene ID: 24137
    neXtProt AC: NX_O95239
    UniProt: O95239

  • Chr Location
    Xq13.1; chrX:70290104-70420886 (+)  GRCh38

  • Human Ortholog
    KIF4B, kinesin family member 4B
  • Links
    NCBI Gene ID: 285643
    neXtProt AC: NX_Q2VIQ3
    UniProt: Q2VIQ3

  • Chr Location
    5q33.2; chr5:155013755-155018141 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human KIF4A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 images
    7 phenotype references
Male chimeras hemizygous for a gene trapped allele appear normal at E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16571 NCBI Gene Model | MGI Sequence Detail 101186 C57BL/6J ±  kb
transcript NM_008446 RefSeq | MGI Sequence Detail 4691 ZRU/MplStud  
polypeptide P33174 UniProt | EBI | MGI Sequence Detail 1231 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 109
    Genomic 1
    cDNA 105
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11593, MGD-MRK-37429, MGI:2147873
References
more
  • Summaries
    All 52
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:3448 Aizawa H, et al., Kinesin family in murine central nervous system. J Cell Biol. 1992 Dec;119(5):1287-96
  • Latest
    J:336792 Wan Y, et al., KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway. J Cell Biol. 2023 Feb 6;222(2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/14/2024
MGI 6.23
The Jackson Laboratory