Tsx MGI Mouse Gene Detail - MGI:108118 - testis specific X-linked gene

Symbol

Tsx
Name

testis specific X-linked gene

Feature Type

protein coding gene
IDs

MGI:108118
NCBI Gene: 22127
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

ChrX:102458073-102468186 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 46.12 cM
Mapping Data

7 experiments

SNPs within 2kb

25 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108118	protein coding gene	ChrX:102452618-102468194 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035984	protein coding gene	ChrX:100056853-100068437 (+)
A/J	MGP_AJ_G0035965	protein coding gene	ChrX:99997128-100006813 (+)
AKR/J	MGP_AKRJ_G0035883	protein coding gene	ChrX:103005380-103015190 (+)
BALB/cJ	MGP_BALBcJ_G0035955	protein coding gene	ChrX:98794656-98804346 (+)
C3H/HeJ	MGP_C3HHeJ_G0035661	protein coding gene	ChrX:100521547-100532219 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036481	protein coding gene	ChrX:103026933-103037529 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033309	protein coding gene	ChrX:97638708-97648589 (+)
CAST/EiJ	MGP_CASTEiJ_G0034947	protein coding gene	ChrX:84793245-84805747 (+)
CBA/J	MGP_CBAJ_G0035636	protein coding gene	ChrX:106203850-106215787 (+)
DBA/2J	MGP_DBA2J_G0035790	protein coding gene	ChrX:99240023-99250067 (+)
FVB/NJ	MGP_FVBNJ_G0035731	protein coding gene	ChrX:98542915-98553460 (+)
LP/J	MGP_LPJ_G0035883	protein coding gene	ChrX:101076579-101086347 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035763	protein coding gene	ChrX:110860601-110871446 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036507	protein coding gene	ChrX:99746025-99756490 (+)
PWK/PhJ	MGP_PWKPhJ_G0034645	protein coding gene	ChrX:82375122-82385362 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034473	protein coding gene	ChrX:85492299-85503337 (+)
WSB/EiJ	MGP_WSBEiJ_G0035087	protein coding gene	ChrX:98471727-98482200 (+)

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MGI Vertebrate Homology

Tsx stringent orthology
1 mouse;1 rat
Gene Tree

Tsx

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Gene trapped

9
Targeted

3
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Female mice homozygous for a knock-out allele exhibit reduced fertility and decreased litter size, while hemizygous males show smaller testis size, pachytene-stage spermatocyte apoptosis, and enhanced contextual conditioning behavior.

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All GO Annotations

6
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

1
cDNA Data

7
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

46
RefSeq

8
UniProt

3
CCDS

CCDS41090.1

Ensembl

ENSMUSG00000031329 (Evidence)
NCBI Gene

22127

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031329	Ensembl Gene Model \| MGI Sequence Detail	10114	C57BL/6J	± kb
transcript	ENSMUST00000033691	Ensembl \| MGI Sequence Detail	812	Not Applicable
polypeptide	ENSMUSP00000033691	Ensembl \| MGI Sequence Detail	144	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016941 testis-specific protein TSX

(term hierarchy)
InterPro Domains

IPR035352 TSX

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All nucleic 17

Genomic 10

cDNA 7

Microarray probesets 2

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MGD-MRK-37155, MGI:2147981

Summaries

All 31

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 5
Earliest

J:36484 Simmler MC, et al., A 94 kb genomic sequence 3' to the murine Xist gene reveals an AT rich region containing a new testis specific gene Tsx. Hum Mol Genet. 1996 Nov;5(11):1713-26
Latest

J:177104 Anguera MC, et al., Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain. PLoS Genet. 2011 Sep;7(9):e1002248

TSS for Tsx:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161720	ChrX:102458067-102458087 (+)	4 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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