About   Help   FAQ
Laptm5 Gene Detail
Summary
  • Symbol
    Laptm5
  • Name
    lysosomal-associated protein transmembrane 5
  • Synonyms
    E3
  • Feature Type
    protein coding gene
  • IDs
    MGI:108046
    NCBI Gene: 16792
  • Alliance
    gene page
  • Transcription Start Sites
    52 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:130640627-130663459 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 64.00 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    323 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108046
 protein coding gene Chr4:130640436-130663459 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028855
 protein coding gene Chr4:132967433-132990326 (+)
A/J MGP_AJ_G0028814
 protein coding gene Chr4:127447280-127471550 (+)
AKR/J MGP_AKRJ_G0028767
 protein coding gene Chr4:131030570-131055071 (+)
BALB/cJ MGP_BALBcJ_G0028837
 protein coding gene Chr4:128064062-128086707 (+)
C3H/HeJ MGP_C3HHeJ_G0028551
 protein coding gene Chr4:131253528-131280376 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029279
 protein coding gene Chr4:137760476-137789260 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026551
 protein coding gene Chr4:120548969-120571857 (+)
CAST/EiJ MGP_CASTEiJ_G0027984
 protein coding gene Chr4:129308638-129333076 (+)
CBA/J MGP_CBAJ_G0028517
 protein coding gene Chr4:141272827-141304341 (+)
DBA/2J MGP_DBA2J_G0028666
 protein coding gene Chr4:127880222-127903297 (+)
FVB/NJ MGP_FVBNJ_G0028633
 protein coding gene Chr4:126706605-126729426 (+)
LP/J MGP_LPJ_G0028767
 protein coding gene Chr4:133118134-133145029 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028659
 protein coding gene Chr4:145964599-145988701 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029317
 protein coding gene Chr4:131406630-131430120 (+)
PWK/PhJ MGP_PWKPhJ_G0027705
 protein coding gene Chr4:124520994-124545027 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027531
 protein coding gene Chr4:127262742-127288522 (+)
WSB/EiJ MGP_WSBEiJ_G0028064
 protein coding gene Chr4:131562682-131585637 (+)



Homology
more
  • Human Ortholog
    LAPTM5, lysosomal protein transmembrane 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAPTM5, lysosomal protein transmembrane 5
  • Synonyms
    CLAST6
  • Links
    NCBI Gene ID: 7805
    UniProt: Q13571

  • Chr Location
    1p35.2; chr1:30732469-30757774 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased T cell proliferation, increased IL-2 production and a prolognged type IV hypersensitivity response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    58
  • cDNA Data
    137
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16792 NCBI Gene Model | MGI Sequence Detail 22833 C57BL/6J ±  kb
transcript NM_010686 RefSeq | MGI Sequence Detail 2416 C57BL/6  
polypeptide Q61168 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    18 Sequences
  • Protein Ontology
    PR:000009666 lysosomal-associated transmembrane protein 5
    (term hierarchy)
  • InterPro Domains
    IPR004687 Lysosomal-associated transmembrane protein 4/5
    IPR018396 Lysosomal-associated transmembrane protein, 4A/5
    IPR051115 Lysosomal-associated transmembrane transporter
Molecular
Reagents
less
  • All nucleic 144
    Genomic 2
    cDNA 139
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-37082
References
more
  • Summaries
    All 61
    Developmental Gene Expression 5
    Gene Ontology 15
    Phenotypes 24
  • Earliest
    J:34144 Adra CN, et al., LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells. Genomics. 1996 Jul 15;35(2):328-37
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/09/2025
MGI 6.24 		The Jackson Laboratory