Zfp36l2 MGI Mouse Gene Detail - MGI:107945 - zinc finger protein 36, C3H type-like 2

Symbol

Zfp36l2
Name

zinc finger protein 36, C3H type-like 2
Synonyms

Brf2, ERF2, Tis11d

Feature Type

protein coding gene
IDs

MGI:107945
NCBI Gene: 12193
Alliance

gene page
Transcription Start Sites

23 TSS

Sequence Map

Chr17:84491359-84495375 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 55.02 cM, cytoband E4
Mapping Data

1 experiment

SNPs within 2kb

24 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107945	protein coding gene	Chr17:84491352-84495375 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024077	protein coding gene	Chr17:87322560-87331906 (-)
A/J	MGP_AJ_G0024036	protein coding gene	Chr17:84572264-84575395 (-)
AKR/J	MGP_AKRJ_G0024005	protein coding gene	Chr17:85941859-85947994 (-)
BALB/cJ	MGP_BALBcJ_G0024037	protein coding gene	Chr17:84421705-84426776 (-)
C3H/HeJ	MGP_C3HHeJ_G0023802	protein coding gene	Chr17:86789896-86794130 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024482	protein coding gene	Chr17:90438623-90441565 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021921	protein coding gene	Chr17:79780902-79784061 (-)
CAST/EiJ	MGP_CASTEiJ_G0023281	protein coding gene	Chr17:87558122-87561262 (-)
CBA/J	MGP_CBAJ_G0023776	protein coding gene	Chr17:94168136-94172630 (-)
DBA/2J	MGP_DBA2J_G0023904	protein coding gene	Chr17:83059244-83063257 (-)
FVB/NJ	MGP_FVBNJ_G0023870	protein coding gene	Chr17:82535339-82539870 (-)
LP/J	MGP_LPJ_G0023988	protein coding gene	Chr17:88085278-88089314 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023898	protein coding gene	Chr17:94279205-94283224 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024527	protein coding gene	Chr17:86430125-86436102 (-)
PWK/PhJ	MGP_PWKPhJ_G0023026	protein coding gene	Chr17:82620624-82622941 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022837	protein coding gene	Chr17:83225713-83231393 (-)
WSB/EiJ	no annotation

Human Ortholog

ZFP36L2, ZFP36 ring finger protein like 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZFP36L2, ZFP36 ring finger protein like 2
Synonyms

BRF2, ERF2, ERF-2, OOMD13, OZEMA13, RNF162C, TIS11D
Links

HGNC:1108

NCBI Gene ID: 678

neXtProt AC: NX_P47974

UniProt: P47974
Chr Location

2p21; chr2:43222402-43226606 (-) GRCh38

MGI Vertebrate Homology

Zfp36l2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZFP36L2
Gene Tree

Zfp36l2

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

25 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

1
Targeted

8
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice expressing decreased levels of an amino-terminal truncated protein display female infertility whereas mice homozygous for a null allele die within two weeks as a result of hematopoietic system defects.

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All GO Annotations

44
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

781
Tissues

45
cDNA Data

156
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zfp36l2, zfp36l2.1, zfp36l2.2

ZFIN zfp36l2

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All Sequences

45
RefSeq

2
UniProt

3
CCDS

CCDS28998.1

Ensembl

ENSMUSG00000045817 (Evidence)
NCBI Gene

12193

			Length	Strain/Species	Flank
genomic	ENSMUSG00000045817	Ensembl Gene Model \| MGI Sequence Detail	4017	C57BL/6J	± kb
transcript	ENSMUST00000060366	Ensembl \| MGI Sequence Detail	3530	Not Applicable
polypeptide	ENSMUSP00000050820	Ensembl \| MGI Sequence Detail	484	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017641 mRNA decay activator protein ZFP36L2

(term hierarchy)
InterPro Domains

IPR045877 RNA-binding protein ZFP36-like

IPR007635 Tis11B-like protein, N-terminal

IPR000571 Zinc finger, CCCH-type

IPR036855 Zinc finger, CCCH-type superfamily

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All nucleic 163

Genomic 1

cDNA 157

Primer pair 2

Other 3

Microarray probesets 6

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MGD-MRK-36525

Summaries

All 58

Developmental Gene Expression 6

Diseases 1

Gene Ontology 13

Phenotypes 20
Earliest

J:33288 Varnum BC, et al., The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol Cell Biol. 1991 Mar;11(3):1754-8
Latest

J:342220 Snyder BL, et al., Synergistic roles of tristetraprolin family members in myeloid cells in the control of inflammation. Life Sci Alliance. 2024 Jan;7(1)

TSS for Zfp36l2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr149672	Chr17:84495367-84495382 (-)	0 bp
Tssr149671	Chr17:84495255-84495327 (-)	84 bp
Tssr149670	Chr17:84495165-84495185 (-)	200 bp
Tssr149669	Chr17:84494632-84494680 (-)	719 bp
Tssr149668	Chr17:84494599-84494618 (-)	766 bp
Tssr149667	Chr17:84494544-84494594 (-)	806 bp
Tssr149666	Chr17:84494455-84494494 (-)	900 bp
Tssr149665	Chr17:84494386-84494432 (-)	966 bp
Tssr149664	Chr17:84494341-84494360 (-)	1,024 bp
Tssr149663	Chr17:84494300-84494317 (-)	1,066 bp
Tssr149662	Chr17:84494236-84494248 (-)	1,133 bp
Tssr149661	Chr17:84494177-84494208 (-)	1,182 bp
Tssr149660	Chr17:84494128-84494145 (-)	1,238 bp
Tssr149659	Chr17:84494097-84494119 (-)	1,267 bp
Tssr149658	Chr17:84494062-84494083 (-)	1,302 bp
Tssr149657	Chr17:84494005-84494040 (-)	1,352 bp
Tssr149656	Chr17:84493789-84493810 (-)	1,575 bp
Tssr149655	Chr17:84493699-84493769 (-)	1,641 bp
Tssr149654	Chr17:84493603-84493625 (-)	1,761 bp
Tssr149653	Chr17:84493463-84493501 (-)	1,893 bp
Tssr149652	Chr17:84493415-84493449 (-)	1,943 bp
Tssr149651	Chr17:84493030-84493069 (-)	2,325 bp
Tssr149650	Chr17:84492992-84493015 (-)	2,371 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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