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Ccr4 Gene Detail
Summary
  • Symbol
    Ccr4
  • Name
    C-C motif chemokine receptor 4
  • Synonyms
    CC CKR-4, Cmkbr4
  • Feature Type
    protein coding gene
  • IDs
    MGI:107824
    NCBI Gene: 12773
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:114319384-114333984 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 64.49 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107824
 protein coding gene Chr9:114319384-114334544 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035388
 protein coding gene Chr9:116919937-116927987 (-)
A/J MGP_AJ_G0035368
 protein coding gene Chr9:112648462-112654313 (-)
AKR/J MGP_AKRJ_G0035301
 protein coding gene Chr9:115507482-115513631 (-)
BALB/cJ MGP_BALBcJ_G0035364
 protein coding gene Chr9:112445863-112451960 (-)
C3H/HeJ MGP_C3HHeJ_G0035072
 protein coding gene Chr9:116020569-116026336 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035887
 protein coding gene Chr9:120120146-120127277 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032770
 protein coding gene Chr9:109948002-109953604 (-)
CAST/EiJ MGP_CASTEiJ_G0034377
 protein coding gene Chr9:115859744-115866101 (-)
CBA/J MGP_CBAJ_G0035039
 protein coding gene Chr9:124604383-124613600 (-)
DBA/2J MGP_DBA2J_G0035198
 protein coding gene Chr9:112126883-112133923 (-)
FVB/NJ MGP_FVBNJ_G0035145
 protein coding gene Chr9:110939126-110944833 (-)
LP/J MGP_LPJ_G0035277
 protein coding gene Chr9:117269755-117276999 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035186
 protein coding gene Chr9:125857957-125864149 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035906
 protein coding gene Chr9:115878183-115886664 (-)
PWK/PhJ MGP_PWKPhJ_G0034083
 protein coding gene Chr9:112420698-112428644 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033917
 protein coding gene Chr9:115931396-115936877 (-)
WSB/EiJ MGP_WSBEiJ_G0034497
 protein coding gene Chr9:115759844-115765571 (-)



Homology
more
  • Human Ortholog
    CCR4, C-C motif chemokine receptor 4
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCR4, C-C motif chemokine receptor 4
  • Synonyms
    CC-CKR-4, CD194, ChemR13, CKR4, CMKBR4, HGCN:14099, K5-5
  • Links
    NCBI Gene ID: 1233
    neXtProt AC: NX_P51679
    UniProt: P51679

  • Chr Location
    3p22.3; chr3:32951644-32956349 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 1 allele in 2 genetic backgrounds
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in decreased mortality, decreased tumor necrosis factor production, and decreased IL-1beta production following LPS administration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    864
  • Tissues
    88
  • cDNA Data
    14
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047898 Ensembl Gene Model | MGI Sequence Detail 14601 C57BL/6J ±  kb
    transcript ENSMUST00000054414 Ensembl | MGI Sequence Detail 2805 Not Applicable  
    polypeptide ENSMUSP00000062677 Ensembl | MGI Sequence Detail 360 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 15
      Primer pair 1
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36401, MGD-MRK-37445
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 49
    • Earliest
      J:30657 Hoogewerf A, et al., Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4. Biochem Biophys Res Commun. 1996 Jan 5;218(1):337-43
    • Latest
      J:334311 Zhao M, et al., Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis. Nat Commun. 2022 Dec 9;13(1):7600
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory