Itm2a MGI Mouse Gene Detail - MGI:107706 - integral membrane protein 2A

Symbol

Itm2a
Name

integral membrane protein 2A
Synonyms

Bricd2a, Itm2

Feature Type

protein coding gene
IDs

MGI:107706
NCBI Gene: 16431
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

ChrX:106440801-106446966 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 47.52 cM, cytoband A2-A3
Mapping Data

5 experiments

SNPs within 2kb

37 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107706	protein coding gene	ChrX:106440705-106446982 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0036014	protein coding gene	ChrX:104236358-104242522 (-)
A/J	MGP_AJ_G0035993	protein coding gene	ChrX:104066630-104072841 (-)
AKR/J	MGP_AKRJ_G0035912	protein coding gene	ChrX:107329606-107335901 (-)
BALB/cJ	MGP_BALBcJ_G0035984	protein coding gene	ChrX:102821750-102828190 (-)
C3H/HeJ	MGP_C3HHeJ_G0035690	protein coding gene	ChrX:104707333-104714360 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036510	protein coding gene	ChrX:107257260-107264635 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033338	protein coding gene	ChrX:101343356-101349467 (-)
CAST/EiJ	MGP_CASTEiJ_G0034977	protein coding gene	ChrX:88789376-88797685 (-)
CBA/J	MGP_CBAJ_G0035666	protein coding gene	ChrX:110616823-110622766 (-)
DBA/2J	MGP_DBA2J_G0035820	protein coding gene	ChrX:103286531-103292681 (-)
FVB/NJ	MGP_FVBNJ_G0035760	protein coding gene	ChrX:102634154-102641402 (-)
LP/J	MGP_LPJ_G0035912	protein coding gene	ChrX:105184908-105191032 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035791	protein coding gene	ChrX:115404629-115410407 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036537	protein coding gene	ChrX:103803149-103809257 (-)
PWK/PhJ	MGP_PWKPhJ_G0034673	protein coding gene	ChrX:86331290-86337747 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034502	protein coding gene	ChrX:89588095-89594121 (-)
WSB/EiJ	MGP_WSBEiJ_G0035115	protein coding gene	ChrX:102550799-102557361 (-)

Human Ortholog

ITM2A, integral membrane protein 2A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ITM2A, integral membrane protein 2A
Synonyms

BRICD2A, E25A
Links

HGNC:6173

NCBI Gene ID: 9452

neXtProt AC: NX_O43736

UniProt: O43736
Chr Location

Xq21.1; chrX:79360384-79367667 (-) GRCh38

MGI Vertebrate Homology

Itm2a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ITM2A
Gene Tree

Itm2a

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Phenotype Summary

2 phenotypes from 3 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
1 images
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

6
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted allele are viable and fertile with no obvious phenotype.

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All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

865
Tissues

78
cDNA Data

133
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ITM2A

Xenbase itm2a

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All Sequences

35
RefSeq

2
UniProt

1
CCDS

CCDS30349.1

Ensembl

ENSMUSG00000031239 (Evidence)
NCBI Gene

16431

			Length	Strain/Species	Flank
genomic	16431	NCBI Gene Model \| MGI Sequence Detail	6166	C57BL/6J	± kb
transcript	NM_008409	RefSeq \| MGI Sequence Detail	1632	BALB/c
polypeptide	Q61500	UniProt \| EBI \| MGI Sequence Detail	263	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000032694 integral membrane protein 2A

(term hierarchy)
InterPro Domains

IPR007084 BRICHOS domain

IPR040145 Integral membrane protein 2

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All nucleic 138

Genomic 1

cDNA 133

Primer pair 4

Microarray probesets 2

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MGD-MRK-36282, MGI:2147997

Summaries

All 39

Developmental Gene Expression 12

Gene Ontology 3

Phenotypes 6
Earliest

J:34815 Deleersnijder W, et al., Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins. J Biol Chem. 1996 Aug 9;271(32):19475-82
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Itm2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164042	ChrX:106447237-106447257 (-)	-281 bp
Tssr164041	ChrX:106446901-106447010 (-)	10 bp
Tssr164040	ChrX:106440921-106440932 (-)	6,039 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23