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Usp17la Gene Detail
Summary
  • Symbol
    Usp17la
  • Name
    ubiquitin specific peptidase 17-like A
  • Synonyms
    Dub1
Location &
Maps
more
  • Sequence Map
    Chr7:104506223-104511874 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 55.69 cM
Strain
Comparison
more
  • SNPs within 2kb
    327 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107699
 protein coding gene Chr7:104506216-104511874 (+)
129S1/SvImJ ENSMUSG00200043935
 protein coding gene Chr7:91264951-91270605 (+)
A/J ENSMUSG00195054642
 protein coding gene Chr7:95767548-95773202 (+)
AKR/J ENSMUSG00220046192
 protein coding gene Chr7:89141579-89147237 (+)
BALB/cJ ENSMUSG00180040580
 protein coding gene Chr7:92447087-92452742 (+)
C3H/HeJ ENSMUSG00175044153
 protein coding gene Chr7:93090143-93095797 (+)
C57BL/6NJ ENSMUSG00215051124
 protein coding gene Chr7:92359564-92365223 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030201
 protein coding gene Chr7:107214626-107217670 (-)
CAST/EiJ ENSTCUG00005052893
 protein coding gene Chr7:95738700-95744339 (+)
CBA/J ENSMUSG00210044852
 protein coding gene Chr7:92915659-92921313 (+)
DBA/2J ENSMUSG00185056756
 protein coding gene Chr7:97268061-97273715 (+)
FVB/NJ ENSMUSG00205035669
 protein coding gene Chr7:92902327-92907979 (+)
JF1/MsJ ENSUMUG00000047445
 protein coding gene Chr7:102358327-102363966 (+)
LP/J ENSMUSG00230042271
 protein coding gene Chr7:103369790-103375444 (+)
NOD/ShiLtJ ENSMUSG00190037018
 protein coding gene Chr7:93222260-93227944 (+)
NZO/HlLtJ ENSMUSG00225014866
 protein coding gene Chr7:101567628-101573269 (+)
PWK/PhJ ENSLUMG00010046877
 protein coding gene Chr7:91439397-91445008 (+)
SPRET/EiJ ENSMSPG00010029969
 protein coding gene Chr7:92583146-92588325 (+)
WSB/EiJ ENSIUOG00005049609
 protein coding gene Chr7:93531014-93536662 (+)



Homology
more
  • Human Ortholog
    USP17L1, ubiquitin specific peptidase 17 like family member 1
  • Vertebrate Orthologs
    29
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP17L1, ubiquitin specific peptidase 17 like family member 1
  • Synonyms
    USP17L1P
  • Links
    NCBI Gene ID: 401447
    UniProt: Q7RTZ2

  • Chr Location
    8p23.1; chr8:7332387-7333979 (+)  GRCh38
  • Human Ortholog
    USP17L10, ubiquitin specific peptidase 17 like family member 10
  • Links
    NCBI Gene ID: 100287144
    UniProt: C9JJH3

  • Chr Location
    chr4:9210657-9212249 (+)  GRCh38
  • Human Ortholog
    USP17L11, ubiquitin specific peptidase 17 like family member 11
  • Links
    NCBI Gene ID: 100287178
    UniProt: C9JVI0

  • Chr Location
    chr4:9215405-9216997 (+)  GRCh38
  • Human Ortholog
    USP17L12, ubiquitin specific peptidase 17 like family member 12
  • Links
    NCBI Gene ID: 100287205
    UniProt: C9JPN9

  • Chr Location
    chr4:9220152-9221744 (+)  GRCh38
  • Human Ortholog
    USP17L13, ubiquitin specific peptidase 17 like family member 13
  • Links
    NCBI Gene ID: 100287238
    UniProt: C9JLJ4

  • Chr Location
    chr4:9224896-9226488 (+)  GRCh38
  • Human Ortholog
    USP17L15, ubiquitin specific peptidase 17 like family member 15
  • Links
    NCBI Gene ID: 100288520
    UniProt: C9J2P7

  • Chr Location
    chr4:9234385-9236046 (+)  GRCh38
  • Human Ortholog
    USP17L17, ubiquitin specific peptidase 17 like family member 17
  • Links
    NCBI Gene ID: 100287327
    UniProt: D6RBQ6

  • Chr Location
    chr4:9243879-9245471 (+)  GRCh38
  • Human Ortholog
    USP17L18, ubiquitin specific peptidase 17 like family member 18
  • Links
    NCBI Gene ID: 100287364
    UniProt: D6R9N7

  • Chr Location
    chr4:9248630-9250222 (+)  GRCh38
  • Human Ortholog
    USP17L19, ubiquitin specific peptidase 17 like family member 19
  • Links
    NCBI Gene ID: 100287404
    UniProt: D6RCP7

  • Chr Location
    chr4:9253378-9254970 (+)  GRCh38
  • Human Ortholog
    USP17L2, ubiquitin specific peptidase 17 like family member 2
  • Synonyms
    DUB-3, DUB3, USP17
  • Links
    NCBI Gene ID: 377630
    UniProt: Q6R6M4

  • Chr Location
    8p23.1; chr8:12136435-12138849 (-)  GRCh38
  • Human Ortholog
    USP17L20, ubiquitin specific peptidase 17 like family member 20
  • Links
    NCBI Gene ID: 100287441
    UniProt: D6RJB6

  • Chr Location
    chr4:9258124-9259716 (+)  GRCh38
  • Human Ortholog
    USP17L21, ubiquitin specific peptidase 17 like family member 21
  • Links
    NCBI Gene ID: 100287478
    UniProt: D6R901

  • Chr Location
    chr4:9262872-9264464 (+)  GRCh38
  • Human Ortholog
    USP17L22, ubiquitin specific peptidase 17 like family member 22
  • Links
    NCBI Gene ID: 100287513
    UniProt: D6RA61

  • Chr Location
    chr4:9267619-9269211 (+)  GRCh38
  • Human Ortholog
    USP17L24, ubiquitin specific peptidase 17 like family member 24
  • Links
    NCBI Gene ID: 728369
    UniProt: Q0WX57

  • Chr Location
    4p16.1; chr4:9325165-9326757 (+)  GRCh38
  • Human Ortholog
    USP17L25, ubiquitin specific peptidase 17 like family member 25
  • Links
    NCBI Gene ID: 728373

  • Chr Location
    4p16.1; chr4:9329911-9331503 (+)  GRCh38
  • Human Ortholog
    USP17L26, ubiquitin specific peptidase 17 like family member 26
  • Links
    NCBI Gene ID: 728379

  • Chr Location
    4p16.1; chr4:9334658-9336250 (+)  GRCh38
  • Human Ortholog
    USP17L27, ubiquitin specific peptidase 17 like family member 27
  • Links
    NCBI Gene ID: 728393

  • Chr Location
    4p16.1; chr4:9344148-9345740 (+)  GRCh38
  • Human Ortholog
    USP17L28, ubiquitin specific peptidase 17 like family member 28
  • Links
    NCBI Gene ID: 728400

  • Chr Location
    4p16.1; chr4:9348893-9350485 (+)  GRCh38
  • Human Ortholog
    USP17L29, ubiquitin specific peptidase 17 like family member 29
  • Links
    NCBI Gene ID: 728405

  • Chr Location
    4p16.1; chr4:9353638-9355230 (+)  GRCh38
  • Human Ortholog
    USP17L3, ubiquitin specific peptidase 17 like family member 3
  • Synonyms
    USP17B, USP17F
  • Links
    NCBI Gene ID: 645836
    UniProt: A6NCW0

  • Chr Location
    8p23.1; chr8:7976393-7977985 (-)  GRCh38
  • Human Ortholog
    USP17L30, ubiquitin specific peptidase 17 like family member 30
  • Links
    NCBI Gene ID: 728419

  • Chr Location
    4p16.1; chr4:9363129-9364721 (+)  GRCh38
  • Human Ortholog
    USP17L4, ubiquitin specific peptidase 17 like family member 4
  • Links
    NCBI Gene ID: 645402
    UniProt: A6NCW7

  • Chr Location
    8p23.1; chr8:7337115-7338707 (+)  GRCh38
  • Human Ortholog
    USP17L5, ubiquitin specific peptidase 17 like family member 5
  • Links
    NCBI Gene ID: 728386
    UniProt: A8MUK1

  • Chr Location
    4p16.1; chr4:9339403-9340995 (+)  GRCh38
  • Human Ortholog
    USP17L6P, ubiquitin specific peptidase 17 like family member 6, pseudogene
  • Synonyms
    DUB4, USP17L6, vDUB4
  • Links
    NCBI Gene ID: 391622
    UniProt: Q6QN14

  • Chr Location
    4p16.1; chr4:9367874-9369070 (+)  GRCh38
  • Human Ortholog
    USP17L7, ubiquitin specific peptidase 17 like family member 7
  • Links
    NCBI Gene ID: 392197
    UniProt: P0C7H9

  • Chr Location
    8p23.1; chr8:12132417-12134099 (-)  GRCh38
  • Human Ortholog
    USP17L8, ubiquitin specific peptidase 17 like family member 8
  • Links
    NCBI Gene ID: 392188
    UniProt: P0C7I0

  • Chr Location
    8p23.1; chr8:7971661-7973253 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Usp17la
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    33 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    644
  • Tissues
    46
  • cDNA Data
    2
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13531 NCBI Gene Model | MGI Sequence Detail 5652 C57BL/6J ±  kb
transcript NM_007887 RefSeq | MGI Sequence Detail 2664 C57BL/6  
polypeptide Q61068 UniProt | EBI | MGI Sequence Detail 526 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006851 ubiquitin carboxyl-terminal hydrolase 17-like protein A
    (term hierarchy)
  • EC
    3.4.19.12
  • InterPro Domains
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR050164 Ubiquitin carboxyl-terminal hydrolases
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease USP, catalytic domain
Molecular
Reagents
less
  • All nucleic 5
    Genomic 1
    cDNA 2
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36275
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:330032 Shi F, et al., Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice. FASEB J. 2022 Aug;36(8):e22445
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory