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Npat Gene Detail
Summary
  • Symbol
    Npat
  • Name
    nuclear protein in the AT region
  • Feature Type
    protein coding gene
  • IDs
    MGI:107605
    NCBI Gene: 244879
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:53448347-53485642 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 29.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    812 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107605
 protein coding gene Chr9:53448347-53486867 (+)
129S1/SvImJ ENSMUSG00200018030
 protein coding gene Chr9:50579512-50616808 (+)
A/J ENSMUSG00195018988
 protein coding gene Chr9:50284713-50322022 (+)
AKR/J ENSMUSG00220031697
 protein coding gene Chr9:50406101-50443397 (+)
BALB/cJ ENSMUSG00180030831
 protein coding gene Chr9:50398065-50435375 (+)
C3H/HeJ ENSMUSG00175013086
 protein coding gene Chr9:50410008-50447316 (+)
C57BL/6NJ ENSMUSG00215034428
 protein coding gene Chr9:50381561-50418854 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032217
 protein coding gene Chr9:50320607-50357474 (+)
CAST/EiJ ENSTCUG00005013498
 protein coding gene Chr9:50329951-50367107 (+)
CBA/J ENSMUSG00210016310
 protein coding gene Chr9:50520682-50558002 (+)
DBA/2J ENSMUSG00185010150
 protein coding gene Chr9:50538592-50575850 (+)
FVB/NJ ENSMUSG00205027099
 protein coding gene Chr9:50802049-50839692 (+)
JF1/MsJ ENSUMUG00000039702
 protein coding gene Chr9:50572897-50610303 (+)
LP/J ENSMUSG00230040865
 protein coding gene Chr9:50790813-50828108 (+)
NOD/ShiLtJ ENSMUSG00190020378
 protein coding gene Chr9:50600395-50637704 (+)
NZO/HlLtJ ENSMUSG00225027788
 protein coding gene Chr9:50794645-50832279 (+)
PWK/PhJ ENSLUMG00010019479
 protein coding gene Chr9:50532061-50569444 (+)
SPRET/EiJ ENSMSPG00010021436
 protein coding gene Chr9:51457612-51495134 (+)
WSB/EiJ ENSIUOG00005017147
 protein coding gene Chr9:50013534-50051296 (+)



Homology
more
  • Human Ortholog
    NPAT, nuclear protein, coactivator of histone transcription
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPAT, nuclear protein, coactivator of histone transcription
  • Synonyms
    E14, E14/NPAT, p220
  • Links
    NCBI Gene ID: 4863
    UniProt: Q14207

  • Chr Location
    11q22.3; chr11:108155280-108222638 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null embryos fail to proceed from the morula to blastocyst stage and have an uncompacted appearance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    602
  • Tissues
    3
  • cDNA Data
    10
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033054 Ensembl Gene Model | MGI Sequence Detail 37296 C57BL/6J ±  kb
    transcript ENSMUST00000035850 Ensembl | MGI Sequence Detail 6062 Not Applicable  
    polypeptide ENSMUSP00000048709 Ensembl | MGI Sequence Detail 1420 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36179, MGI:2143040, MGI:2143360
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:33856 Matsuda Y, et al., Comparative genome mapping of the ataxia-telangiectasia region in mouse, rat, and Syrian hamster. Genomics. 1996 Jun 15;34(3):347-52
    • Latest
      J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory