Wbp1l MGI Mouse Gene Detail - MGI:107577 - WW domain binding protein 1 like

Symbol

Wbp1l
Name

WW domain binding protein 1 like
Synonyms

D19Wsu162e

Feature Type

protein coding gene
IDs

MGI:107577
NCBI Gene: 226178
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr19:46587545-46645828 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 38.97 cM
Mapping Data

4 experiments

SNPs within 2kb

3419 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107577	protein coding gene	Chr19:46587523-46645828 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025213	protein coding gene	Chr19:46339778-46406433 (+)
A/J	MGP_AJ_G0025189	protein coding gene	Chr19:44021428-44080917 (+)
AKR/J	MGP_AKRJ_G0025158	protein coding gene	Chr19:45456483-45516597 (+)
BALB/cJ	MGP_BALBcJ_G0025184	protein coding gene	Chr19:44077241-44137051 (+)
C3H/HeJ	MGP_C3HHeJ_G0024944	protein coding gene	Chr19:45634678-45697328 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025627	protein coding gene	Chr19:47453510-47519303 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023041	protein coding gene	Chr19:43266421-43325752 (+)
CAST/EiJ	MGP_CASTEiJ_G0024409	protein coding gene	Chr19:45441627-45509005 (+)
CBA/J	MGP_CBAJ_G0024924	protein coding gene	Chr19:49843884-49905250 (+)
DBA/2J	MGP_DBA2J_G0025056	protein coding gene	Chr19:43842562-43901819 (+)
FVB/NJ	MGP_FVBNJ_G0025017	protein coding gene	Chr19:43626743-43686753 (+)
LP/J	MGP_LPJ_G0025142	protein coding gene	Chr19:46227511-46288636 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025048	protein coding gene	Chr19:49185870-49248429 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025685	protein coding gene	Chr19:45568030-45632484 (+)
PWK/PhJ	MGP_PWKPhJ_G0024158	protein coding gene	Chr19:43795026-43857712 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023962	protein coding gene	Chr19:44212680-44279170 (+)
WSB/EiJ	MGP_WSBEiJ_G0024479	protein coding gene	Chr19:45716244-45780368 (+)

Human Ortholog

WBP1L, WW domain binding protein 1 like

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WBP1L, WW domain binding protein 1 like
Synonyms

C10orf26, OPA1L, OPAL1
Links

HGNC:23510

NCBI Gene ID: 54838

UniProt: Q9NX94
Chr Location

10q24.32; chr10:102743948-102834516 (+) GRCh38

MGI Vertebrate Homology

Wbp1l stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: WBP1L
Gene Tree

Wbp1l

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Phenotype Summary

23 phenotypes from 3 alleles in 3 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

1
Gene trapped

8
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele impaired B cell development.

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All GO Annotations

8
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

793
Tissues

48
cDNA Data

161
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wbp1l

ZFIN wbp1lb

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All Sequences

58
RefSeq

6
UniProt

1
CCDS

CCDS29881.2, CCDS50456.1, CCDS50457.1

Ensembl

ENSMUSG00000047731 (Evidence)
NCBI Gene

226178

			Length	Strain/Species	Flank
genomic	226178	NCBI Gene Model \| MGI Sequence Detail	58284	C57BL/6J	± kb
transcript	NM_001177812	RefSeq \| MGI Sequence Detail	3946	ZRU/MplStud
polypeptide	Q8BGW2	UniProt \| EBI \| MGI Sequence Detail	348	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031354 WW domain binding protein 1-like

(term hierarchy)
InterPro Domains

IPR051994 WW domain-binding

IPR021684 WW domain-binding protein 1-like
GlyGen

Q8BGW2 1 site

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All nucleic 162

cDNA 161

Primer pair 1

Microarray probesets 8

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MGD-MRK-36149

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 2

Phenotypes 13
Earliest

J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
Latest

J:359109 Krayem I, et al., WBP1L regulates hematopoietic stem cell function and T cell development. Front Immunol. 2024;15:1421512

TSS for Wbp1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156786	Chr19:46587520-46587589 (+)	10 bp
Tssr156787	Chr19:46587591-46587617 (+)	59 bp
Tssr156788	Chr19:46600924-46600933 (+)	13,384 bp
Tssr156789	Chr19:46607086-46607092 (+)	19,544 bp
Tssr156790	Chr19:46611826-46611890 (+)	24,313 bp
Tssr156791	Chr19:46612809-46612825 (+)	25,272 bp
Tssr5539	Chr19:46624262-46624270 (+)	36,721 bp
Tssr156792	Chr19:46641161-46641179 (+)	53,625 bp
Tssr156793	Chr19:46642442-46642466 (+)	54,909 bp
Tssr156794	Chr19:46642472-46642480 (+)	54,931 bp
Tssr156795	Chr19:46642544-46642573 (+)	55,014 bp
Tssr156796	Chr19:46642810-46642857 (+)	55,289 bp
Tssr156797	Chr19:46643049-46643075 (+)	55,517 bp
Tssr156798	Chr19:46643260-46643282 (+)	55,726 bp
Tssr156799	Chr19:46643368-46643398 (+)	55,838 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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