Prol1 MGI Mouse Gene Detail - MGI:107496 - proline rich, lacrimal 1

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Prol1 Gene Detail

Symbol

Prol1
Name

proline rich, lacrimal 1
Synonyms

Muc10

Feature Type

protein coding gene
IDs

MGI:107496
NCBI Gene: 17830
Alliance

gene page
Transcription Start Sites

22 TSS

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Sequence Map

Chr5:88465171-88476673 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 43.56 cM, cytoband E2
Mapping Data

1 experiment

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SNPs within 2kb

54 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_107496	protein coding gene	Chr5:88465171-88476676 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029704	protein coding gene	Chr5:89323454-89336645 (+)
A/J	MGP_AJ_G0029670	protein coding gene	Chr5:85769176-85781242 (+)
AKR/J	MGP_AKRJ_G0029616	protein coding gene	Chr5:88615703-88627058 (+)
BALB/cJ	MGP_BALBcJ_G0029680	protein coding gene	Chr5:86675444-86693920 (+)
C3H/HeJ	MGP_C3HHeJ_G0029403	protein coding gene	Chr5:88960096-88972408 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030134	protein coding gene	Chr5:92973230-92974322 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0028813	protein coding gene	Chr5:88373908-88386593 (+)
CBA/J	MGP_CBAJ_G0029372	protein coding gene	Chr5:96026461-96038827 (+)
DBA/2J	MGP_DBA2J_G0029517	protein coding gene	Chr5:85857460-85868725 (+)
FVB/NJ	MGP_FVBNJ_G0029476	protein coding gene	Chr5:84790121-84802700 (+)
LP/J	MGP_LPJ_G0029605	protein coding gene	Chr5:89715449-89727340 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029505	protein coding gene	Chr5:101064221-101077429 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030168	protein coding gene	Chr5:88136543-88151855 (+)
PWK/PhJ	MGP_PWKPhJ_G0028532	protein coding gene	Chr5:84915172-84927995 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028367	protein coding gene	Chr5:87588773-87600637 (+)
WSB/EiJ	MGP_WSBEiJ_G0028892	protein coding gene	Chr5:88532994-88546750 (+)

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MGI Vertebrate Homology

Prol1 stringent orthology
1 mouse;1 rat
Gene Tree

Prol1

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Phenotype Summary

8 phenotype references

All Mutations and Alleles

6
Chemically induced (other)

2
Endonuclease-mediated

1
Radiation induced

1
Spontaneous

1
Targeted

1
Genomic Mutations

4 involving Prol1
Incidental Mutations

APF
Find Mice (IMSR)

14 strains or lines available

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All GO Annotations

3
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

760
Tissues

14
cDNA Data

133
Literature Summary

10

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
UniProt

5
CCDS

CCDS51537.1

Ensembl

ENSMUSG00000064156 (Evidence)
NCBI Gene

17830

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000064156	Ensembl Gene Model \| MGI Sequence Detail	11503	C57BL/6J	± kb
	transcript	ENSMUST00000170832	Ensembl \| MGI Sequence Detail	1163	Not Applicable
	polypeptide	ENSMUSP00000132678	Ensembl \| MGI Sequence Detail	312	Not Applicable

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UniProt

5 Sequences

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All nucleic 135

cDNA 133

Primer pair 2

Microarray probesets 4

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MGD-MRK-36064

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Summaries

All 36

Developmental Gene Expression 10

Gene Ontology 2

Phenotypes 8
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:341713 Aure MH, et al., FGFR2 is essential for salivary gland duct homeostasis and MAPK-dependent seromucous acinar cell differentiation. Nat Commun. 2023 Oct 14;14(1):6485

TSS for Prol1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46975	Chr5:88464936-88464945 (+)	-230 bp
Tssr46976	Chr5:88465146-88465165 (+)	-15 bp
Tssr46977	Chr5:88466425-88466430 (+)	1,257 bp
Tssr46978	Chr5:88466432-88466449 (+)	1,270 bp
Tssr46979	Chr5:88475663-88475679 (+)	10,500 bp
Tssr46980	Chr5:88475684-88475696 (+)	10,519 bp
Tssr46981	Chr5:88475705-88475718 (+)	10,541 bp
Tssr46982	Chr5:88475722-88475737 (+)	10,559 bp
Tssr46983	Chr5:88475747-88475761 (+)	10,583 bp
Tssr46984	Chr5:88475763-88475779 (+)	10,600 bp
Tssr46985	Chr5:88475783-88475790 (+)	10,616 bp
Tssr46986	Chr5:88475797-88475870 (+)	10,663 bp
Tssr46987	Chr5:88475887-88475901 (+)	10,723 bp
Tssr46988	Chr5:88475909-88475947 (+)	10,757 bp
Tssr46989	Chr5:88475948-88475960 (+)	10,783 bp
Tssr46990	Chr5:88475987-88476000 (+)	10,823 bp
Tssr46991	Chr5:88476004-88476037 (+)	10,850 bp
Tssr46992	Chr5:88476065-88476081 (+)	10,902 bp
Tssr46993	Chr5:88476082-88476116 (+)	10,928 bp
Tssr46994	Chr5:88476142-88476194 (+)	10,997 bp
Tssr46995	Chr5:88476200-88476232 (+)	11,045 bp
Tssr46996	Chr5:88476278-88476283 (+)	11,110 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23