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Tcea2 Gene Detail
Summary
  • Symbol
    Tcea2
  • Name
    transcription elongation factor A (SII), 2
  • Synonyms
    S-II-T1, SII-T1, Tceat
  • Feature Type
    protein coding gene
  • IDs
    MGI:107368
    NCBI Gene: 21400
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:181322103-181329864 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 103.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107368
protein coding gene Chr2:181322090-181329864 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027033
protein coding gene Chr2:188303045-188310807 (+)
A/J MGP_AJ_G0026999
protein coding gene Chr2:180535890-180543649 (+)
AKR/J MGP_AKRJ_G0026969
protein coding gene Chr2:185952647-185960406 (+)
BALB/cJ MGP_BALBcJ_G0027007
protein coding gene Chr2:181016434-181024195 (+)
C3H/HeJ MGP_C3HHeJ_G0026749
protein coding gene Chr2:186296694-186304453 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027453
protein coding gene Chr2:193741302-193749063 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024817
protein coding gene Chr2:171216471-171224153 (+)
CAST/EiJ MGP_CASTEiJ_G0026208
protein coding gene Chr2:184575622-184583396 (+)
CBA/J MGP_CBAJ_G0026726
protein coding gene Chr2:200764256-200772017 (+)
DBA/2J MGP_DBA2J_G0026863
protein coding gene Chr2:179638273-179646032 (+)
FVB/NJ MGP_FVBNJ_G0026829
protein coding gene Chr2:178258567-178266328 (+)
LP/J MGP_LPJ_G0026965
protein coding gene Chr2:188320531-188328330 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026849
protein coding gene Chr2:203315201-203322963 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027513
protein coding gene Chr2:185928532-185936293 (+)
PWK/PhJ MGP_PWKPhJ_G0025944
protein coding gene Chr2:177168325-177176094 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025744
protein coding gene Chr2:182419322-182427077 (+)
WSB/EiJ MGP_WSBEiJ_G0026280
protein coding gene Chr2:186911841-186919600 (+)



Homology
more
  • Human Ortholog
    TCEA2, transcription elongation factor A2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCEA2, transcription elongation factor A2
  • Synonyms
    TFIIS
  • Links
    NCBI Gene ID: 6919
    neXtProt AC: NX_Q15560
    UniProt: Q15560

  • Chr Location
    20q13.33; chr20:64042350-64072347 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059540 Ensembl Gene Model | MGI Sequence Detail 7762 C57BL/6J ±  kb
    transcript ENSMUST00000103042 Ensembl | MGI Sequence Detail 1183 Not Applicable  
    polypeptide ENSMUSP00000099331 Ensembl | MGI Sequence Detail 299 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000016158 transcription elongation factor A protein 2
    • InterPro Domains
      IPR035441 TFIIS/LEDGF domain superfamily
      IPR035100 Transcription elongation factor, IIS-type
      IPR003618 Transcription elongation factor S-II, central domain
      IPR036575 Transcription elongation factor S-II, central domain superfamily
      IPR006289 Transcription elongation factor, TFIIS
      IPR003617 Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
      IPR017923 Transcription factor IIS, N-terminal
      IPR001222 Zinc finger, TFIIS-type
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 2
      cDNA 31

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35835, MGI:2138911
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 7
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:44380 Kanai A, et al., Heterogeneity and tissue-specific expression of eukaryotic transcription factor S-II-related protein mRNA. J Biochem. 1991 May;109(5):674-7
    • Latest
      J:263646 Horiuchi K, et al., Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Cell Rep. 2018 Apr 3;23(1):143-155

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    01/24/2023
    MGI 6.22
    The Jackson Laboratory