Arnt2 MGI Mouse Gene Detail - MGI:107188 - aryl hydrocarbon receptor nuclear translocator 2

Symbol

Arnt2
Name

aryl hydrocarbon receptor nuclear translocator 2
Synonyms

bHLHe1, mKIAA0307

Feature Type

protein coding gene
IDs

MGI:107188
NCBI Gene: 11864
Alliance

genome feature page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:83895486-84059201 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 48.35 cM
Mapping Data

4 experiments

SNPs within 2kb

4532 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107188	protein coding gene	Chr7:83895486-84059384 (-)
129S1/SvImJ	ENSMUSG00200033562	protein coding gene	Chr7:70702331-70863522 (-)
A/J	ENSMUSG00195040926	protein coding gene	Chr7:75166439-75328448 (-)
AKR/J	ENSMUSG00220035640	protein coding gene	Chr7:68684608-68846624 (-)
BALB/cJ	ENSMUSG00180034047	protein coding gene	Chr7:71872027-72034035 (-)
C3H/HeJ	ENSMUSG00175030534	protein coding gene	Chr7:72614373-72775571 (-)
C57BL/6NJ	ENSMUSG00215016388	protein coding gene	Chr7:71725090-71889009 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029947	protein coding gene	Chr7:86689864-86846716 (-)
CAST/EiJ	ENSTCUG00005041269	protein coding gene	Chr7:75185851-75346428 (-)
CBA/J	ENSMUSG00210039563	protein coding gene	Chr7:72476642-72637838 (-)
DBA/2J	ENSMUSG00185046227	protein coding gene	Chr7:76788010-76949201 (-)
FVB/NJ	ENSMUSG00205020152	protein coding gene	Chr7:72422820-72584798 (-)
JF1/MsJ	ENSUMUG00000017693	protein coding gene	Chr7:81497856-81663281 (-)
LP/J	ENSMUSG00230015092	protein coding gene	Chr7:82877400-83038566 (-)
NOD/ShiLtJ	ENSMUSG00190024674	protein coding gene	Chr7:72629063-72791050 (-)
NZO/HlLtJ	ENSMUSG00225010268	protein coding gene	Chr7:81152242-81313426 (-)
PWK/PhJ	ENSLUMG00010034197	protein coding gene	Chr7:71084859-71243396 (-)
SPRET/EiJ	ENSMSPG00010011331	protein coding gene	Chr7:71516965-71683804 (-)
WSB/EiJ	ENSIUOG00005029534	protein coding gene	Chr7:72960606-73122613 (-)

Human Ortholog

ARNT2, aryl hydrocarbon receptor nuclear translocator 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARNT2, aryl hydrocarbon receptor nuclear translocator 2
Synonyms

bHLHe1, WEDAS
Links

HGNC:16876

NCBI Gene ID: 9915

UniProt: Q9HBZ2
Chr Location

15q25.1; chr15:80404315-80597937 (+) GRCh38

MGI Vertebrate Homology

Arnt2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARNT2
Gene Tree

Arnt2

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Phenotype Summary

21 phenotypes from 4 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Arnt2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for targeted mutations that inactivate this gene die shortly after birth, displaying impaired development of secretory neurons in the hypothalamus.

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All GO Annotations

65
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1094
Tissues

315
cDNA Data

14
Literature Summary

24

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ARNT2

Xenbase arnt2

ZFIN arnt2

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All Sequences

81
RefSeq

16
UniProt

8
CCDS

CCDS59733.1

Ensembl

ENSMUSG00000015709 (Evidence)
NCBI Gene

11864

			Length	Strain/Species	Flank
genomic	11864	NCBI Gene Model \| MGI Sequence Detail	163716	C57BL/6J	± kb
transcript	NM_007488	RefSeq \| MGI Sequence Detail	6073	ZRU/MplStud
polypeptide	Q61324	UniProt \| EBI \| MGI Sequence Detail	712	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000004304 aryl hydrocarbon receptor nuclear translocator 2

(term hierarchy)
PDB

7XI3
InterPro Domains

IPR050933 Circadian Clock Transcription Factors

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

IPR001067 Nuclear translocator

IPR001610 PAC motif

IPR000014 PAS domain

IPR035965 PAS domain superfamily

IPR013767 PAS fold
GlyGen

Q61324 1 site, 1 N-linked glycan (1 site)

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All nucleic 29

Genomic 11

cDNA 15

Primer pair 3

Microarray probesets 8

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MGD-MRK-35649

Summaries

All 84

Developmental Gene Expression 24

Gene Ontology 16

Phenotypes 18
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:354622 Choi J, et al., ARNT2 controls prefrontal somatostatin interneurons mediating affective empathy. Cell Rep. 2024 Sep 24;43(9):114659

TSS for Arnt2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73434	Chr7:84059329-84059350 (-)	-139 bp
Tssr73433	Chr7:84059269-84059276 (-)	-72 bp
Tssr73432	Chr7:84059235-84059256 (-)	-45 bp
Tssr2321	Chr7:84059218-84059229 (-)	-23 bp
Tssr73431	Chr7:84059170-84059210 (-)	11 bp
Tssr73430	Chr7:84059090-84059132 (-)	90 bp
Tssr73429	Chr7:84021864-84021892 (-)	37,323 bp
Tssr73428	Chr7:84021655-84021671 (-)	37,538 bp
Tssr73427	Chr7:84021620-84021654 (-)	37,564 bp
Tssr73426	Chr7:83924742-83924792 (-)	134,434 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24