Srp14 MGI Mouse Gene Detail - MGI:107169 - signal recognition particle 14

Symbol

Srp14
Name

signal recognition particle 14
Synonyms

14kDa, (homologous Alu RNA binding protein)

Feature Type

protein coding gene
IDs

MGI:107169
NCBI Gene: 20813
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:118306324-118310177 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 59.40 cM
Mapping Data

2 experiments

SNPs within 2kb

186 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107169	protein coding gene	Chr2:118306324-118310192 (-)
129S1/SvImJ	ENSMUSG00200044399	protein coding gene	Chr2:115241762-115244894 (-)
A/J	ENSMUSG00195022124	protein coding gene	Chr2:115290081-115293211 (-)
AKR/J	ENSMUSG00220034498	protein coding gene	Chr2:115168497-115171628 (-)
BALB/cJ	ENSMUSG00180036871	protein coding gene	Chr2:115095198-115098328 (-)
C3H/HeJ	ENSMUSG00175022387	protein coding gene	Chr2:115559677-115562801 (-)
C57BL/6NJ	ENSMUSG00215029618	protein coding gene	Chr2:115222379-115226240 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024116	protein coding gene	Chr2:111292653-111296583 (-)
CAST/EiJ	ENSTCUG00005016338	protein coding gene	Chr2:114495783-114498895 (-)
CBA/J	ENSMUSG00210006885	protein coding gene	Chr2:115400639-115403763 (-)
DBA/2J	ENSMUSG00185043742	protein coding gene	Chr2:115091884-115095014 (-)
FVB/NJ	ENSMUSG00205018021	protein coding gene	Chr2:114306818-114309949 (-)
JF1/MsJ	ENSUMUG00000014103	protein coding gene	Chr2:114960835-114964696 (-)
LP/J	ENSMUSG00230015401	protein coding gene	Chr2:116898236-116904692 (-)
NOD/ShiLtJ	ENSMUSG00190041600	protein coding gene	Chr2:115328734-115331858 (-)
NZO/HlLtJ	ENSMUSG00225002303	protein coding gene	Chr2:124804050-124810498 (-)
PWK/PhJ	ENSLUMG00010047291	protein coding gene	Chr2:114868691-114871800 (-)
SPRET/EiJ	ENSMSPG00010032058	protein coding gene	Chr2:117264349-117268244 (-)
WSB/EiJ	ENSIUOG00005028526	protein coding gene	Chr2:115060429-115063558 (-)

Human Ortholog

SRP14, signal recognition particle 14

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SRP14, signal recognition particle 14
Synonyms

ALURBP
Links

HGNC:11299

NCBI Gene ID: 6727

UniProt: P37108
Chr Location

15q15.1; chr15:40035690-40039202 (-) GRCh38

MGI Vertebrate Homology

Srp14 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SRP14
Gene Tree

Srp14

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Srp14
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

637
Tissues

8
cDNA Data

178
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase srp14

ZFIN srp14

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All Sequences

43
RefSeq

2
UniProt

2
CCDS

CCDS16577.1

Ensembl

ENSMUSG00000009549 (Evidence)
NCBI Gene

20813

			Length	Strain/Species	Flank
genomic	20813	NCBI Gene Model \| MGI Sequence Detail	3854	C57BL/6J	± kb
transcript	NM_009273	RefSeq \| MGI Sequence Detail	790	C57BL/6
polypeptide	P16254	UniProt \| EBI \| MGI Sequence Detail	110	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015623 signal recognition particle 14 kDa protein

(term hierarchy)
PDB

1914
InterPro Domains

IPR003210 Signal recognition particle, SRP14 subunit

IPR009018 Signal recognition particle, SRP9/SRP14 subunit
GlyGen

P16254 1 site, 1 O-linked glycan (1 site)

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All nucleic 180

cDNA 178

Primer pair 2

Microarray probesets 5

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MGD-MRK-35630, MGI:2139363

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Srp14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25775	Chr2:118310118-118310168 (-)	34 bp
Tssr25774	Chr2:118309500-118309526 (-)	664 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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