Cldn11 MGI Mouse Gene Detail - MGI:106925

Symbol

Cldn11
Name

claudin 11
Synonyms

oligodendrocyte-specific protein, Osp, Otm

Feature Type

protein coding gene
IDs

MGI:106925
NCBI Gene: 18417
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr3:31204069-31218473 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 15.14 cM
Mapping Data

7 experiments

SNPs within 2kb

36 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106925	protein coding gene	Chr3:31204069-31218475 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027132	protein coding gene	Chr3:28678017-28693270 (+)
A/J	MGP_AJ_G0027092	protein coding gene	Chr3:28299656-28314724 (+)
AKR/J	MGP_AKRJ_G0027061	protein coding gene	Chr3:28733347-28749512 (+)
BALB/cJ	MGP_BALBcJ_G0027104	protein coding gene	Chr3:27984813-27999957 (+)
C3H/HeJ	MGP_C3HHeJ_G0026846	protein coding gene	Chr3:28748321-28771208 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027550	protein coding gene	Chr3:30196772-30215504 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024911	protein coding gene	Chr3:26200451-26214525 (+)
CAST/EiJ	MGP_CASTEiJ_G0026300	protein coding gene	Chr3:28673764-28691246 (+)
CBA/J	MGP_CBAJ_G0026824	protein coding gene	Chr3:30956321-30970723 (+)
DBA/2J	MGP_DBA2J_G0026958	protein coding gene	Chr3:27844541-27858970 (+)
FVB/NJ	MGP_FVBNJ_G0026926	protein coding gene	Chr3:27293078-27307612 (+)
LP/J	MGP_LPJ_G0027069	protein coding gene	Chr3:29374477-29402814 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026946	protein coding gene	Chr3:33535204-33549938 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027609	protein coding gene	Chr3:28512943-28528865 (+)
PWK/PhJ	MGP_PWKPhJ_G0026033	protein coding gene	Chr3:27363277-27378336 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025845	protein coding gene	Chr3:27999456-28014937 (+)
WSB/EiJ	MGP_WSBEiJ_G0026374	protein coding gene	Chr3:28573523-28593784 (+)

Human Ortholog

CLDN11, claudin 11

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLDN11, claudin 11
Synonyms

HLD22, OSP, OTM
Links

HGNC:8514

NCBI Gene ID: 5010

neXtProt AC: NX_O75508

UniProt: O75508
Chr Location

3q26.2; chr3:170418868-170454733 (+) GRCh38

MGI Vertebrate Homology

Cldn11 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CLDN11
Gene Tree

Cldn11

Diseases

1 with human CLDN11 associations

				Human Disease	Mouse Models
				hypomyelinating leukodystrophy 22 IDs hypomyelinating leukodystrophy 22 DOID:0070402 OMIM:619328

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

24 phenotypes from 3 alleles in 3 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

6
Radiation induced

1
Targeted

3
Transgenic

1
Genomic Mutations

1 involving Cldn11
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice exhibit tremors, impaired coordination, hindlimb weakness, abnormal myelination of the cranial nerves, increased auditory thresholds, and abnormal stria vascularis. Mutant males have small testes, abnormal seminiferous tubules, and sperm abnormalities resulting in infertility.

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All GO Annotations

30
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

971
Tissues

67
cDNA Data

23
Literature Summary

48

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CLDN11

Xenbase cldn11

ZFIN cldn11a, cldn11b

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS17290.1

Ensembl

ENSMUSG00000037625 (Evidence)
NCBI Gene

18417

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037625	Ensembl Gene Model \| MGI Sequence Detail	14405	C57BL/6J	± kb
transcript	ENSMUST00000046174	Ensembl \| MGI Sequence Detail	1870	Not Applicable
polypeptide	ENSMUSP00000042181	Ensembl \| MGI Sequence Detail	207	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005539 claudin-11

(term hierarchy)
InterPro Domains

IPR006187 Claudin

IPR003555 Claudin-11

IPR017974 Claudin, conserved site

IPR004031 PMP-22/EMP/MP20/Claudin

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All nucleic 31

cDNA 23

Primer pair 7

Other 1

Microarray probesets 3

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MGD-MRK-35386

Summaries

All 109

Developmental Gene Expression 48

Diseases 1

Gene Ontology 12

Phenotypes 21
Earliest

J:33372 Bronstein JM, et al., Chromosomal localization of murine and human oligodendrocyte-specific protein genes. Genomics. 1996 Jun 1;34(2):255-7
Latest

J:338955 Maezawa S, et al., PRC1 suppresses a female gene regulatory network to ensure testicular differentiation. Cell Death Dis. 2023 Aug 4;14(8):501

TSS for Cldn11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28722	Chr3:31203899-31203914 (+)	-162 bp
Tssr28723	Chr3:31203920-31203936 (+)	-141 bp
Tssr28724	Chr3:31204083-31204107 (+)	26 bp
Tssr28725	Chr3:31204113-31204128 (+)	52 bp
Tssr28726	Chr3:31217287-31217300 (+)	13,225 bp
Tssr28727	Chr3:31217501-31217512 (+)	13,438 bp
Tssr28728	Chr3:31217526-31217537 (+)	13,463 bp
Tssr28729	Chr3:31218025-31218039 (+)	13,963 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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