Ly75 MGI Mouse Gene Detail - MGI:106662

Symbol

Ly75
Name

lymphocyte antigen 75
Synonyms

CD205, DEC-205

Feature Type

protein coding gene
IDs

MGI:106662
NCBI Gene: 17076
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:60122447-60213617 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 34.54 cM
Mapping Data

2 experiments

SNPs within 2kb

2560 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106662	protein coding gene	Chr2:60122447-60213647 (-)
129S1/SvImJ	ENSMUSG00200002570	protein coding gene	Chr2:57190899-57281377 (-)
A/J	ENSMUSG00195004834	protein coding gene	Chr2:57308752-57400641 (-)
AKR/J	ENSMUSG00220007038	protein coding gene	Chr2:57410842-57502744 (-)
BALB/cJ	ENSMUSG00180019525	protein coding gene	Chr2:57264926-57356824 (-)
C3H/HeJ	ENSMUSG00175013645	protein coding gene	Chr2:57333759-57425654 (-)
C57BL/6NJ	ENSMUSG00215007164	protein coding gene	Chr2:57318423-57410323 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023583	protein coding gene	Chr2:55151050-55239178 (-)
CAST/EiJ	ENSTCUG00005022219	protein coding gene	Chr2:56667843-56758638 (-)
CBA/J	ENSMUSG00210033697	protein coding gene	Chr2:57352887-57444773 (-)
DBA/2J	ENSMUSG00185008192	protein coding gene	Chr2:57209226-57301152 (-)
FVB/NJ	ENSMUSG00205017291	protein coding gene	Chr2:56849635-56941530 (-)
JF1/MsJ	ENSUMUG00000018375	protein coding gene	Chr2:56903322-56999055 (-)
LP/J	ENSMUSG00230001240	protein coding gene	Chr2:59074632-59165085 (-)
NOD/ShiLtJ	ENSMUSG00190026780	protein coding gene	Chr2:57298179-57390036 (-)
NZO/HlLtJ	ENSMUSG00225000652	protein coding gene	Chr2:66797573-66889447 (-)
PWK/PhJ	ENSLUMG00010005354	protein coding gene	Chr2:57067090-57162667 (-)
SPRET/EiJ	ENSMSPG00010011756	protein coding gene	Chr2:58228877-58317827 (-)
WSB/EiJ	ENSIUOG00005027314	protein coding gene	Chr2:57336301-57427035 (-)

Human Ortholog

LY75, lymphocyte antigen 75

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LY75, lymphocyte antigen 75
Synonyms

CD205, CLEC13B, DEC-205, GP200-MR6, LY-75
Links

HGNC:6729

NCBI Gene ID: 4065

UniProt: O60449
Chr Location

2q24.2; chr2:159803355-159904756 (-) GRCh38

Human Ortholog

LY75-CD302, LY75-CD302 readthrough
Synonyms

gp200-MR6
Links

HGNC:38828

NCBI Gene ID: 100526664
Chr Location

2q24.2; chr2:159768628-159904756 (-) GRCh38

MGI Vertebrate Homology

Ly75 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LY75, LY75-CD302
Gene Tree

Ly75

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

4
Targeted

3
Genomic Mutations

1 involving Ly75
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

76 strains or lines available

Mice homozygous for a knock-out allele display abnormalities in CD8-positive T cell morphology and cytotoxic T cell physiology.

less

All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

619
Tissues

6
cDNA Data

22
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ly75

ZFIN ly75

less

All Sequences

40
RefSeq

2
UniProt

4
CCDS

CCDS38126.1

Ensembl

ENSMUSG00000026980 (Evidence)
NCBI Gene

17076

			Length	Strain/Species	Flank
genomic	17076	NCBI Gene Model \| MGI Sequence Detail	91171	C57BL/6J	± kb
transcript	NM_013825	RefSeq \| MGI Sequence Detail	6871	C57BL/6
polypeptide	Q60767	UniProt \| EBI \| MGI Sequence Detail	1723	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000001026 lymphocyte antigen 75

(term hierarchy)
InterPro Domains

IPR050111 C-type lectin and snaclec domain-containing protein

IPR018378 C-type lectin, conserved site

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

IPR000562 Fibronectin type II domain

IPR036943 Fibronectin type II domain superfamily

IPR013806 Kringle-like fold

IPR000772 Ricin B, lectin domain

IPR035992 Ricin B-like lectins
GlyGen

Q60767 17 sites, 7 N-linked glycans (7 sites), 1 O-linked glycan (1 site)

less

All nucleic 23

cDNA 22

Primer pair 1

Antibodies 2

Microarray probesets 3

less

MGD-MRK-35120

Summaries

All 79

Developmental Gene Expression 13

Gene Ontology 4

Phenotypes 38
Earliest

J:25283 Jiang W, et al., The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature. 1995 May 11;375(6527):151-5
Latest

J:376646 Pae J, et al., Transient silencing of hypermutation preserves B cell affinity during clonal bursting. Nature. 2025 May;641(8062):486-494

TSS for Ly75:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr24202	Chr2:60213652-60213658 (-)	-38 bp
Tssr24201	Chr2:60213640-60213647 (-)	-27 bp
Tssr24200	Chr2:60213579-60213634 (-)	10 bp
Tssr24199	Chr2:60200685-60200688 (-)	12,930 bp
Tssr24198	Chr2:60142593-60142598 (-)	71,021 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24