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Slc30a2 Gene Detail
Summary
  • Symbol
    Slc30a2
  • Name
    solute carrier family 30 (zinc transporter), member 2
  • Synonyms
    Znt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:106637
    NCBI Gene: 230810
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:134070492-134081795 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 66.61 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    447 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106637
 protein coding gene Chr4:134070357-134081795 (+)
129S1/SvImJ ENSMUSG00200019299
 protein coding gene Chr4:127500025-127511308 (+)
A/J ENSMUSG00195039757
 protein coding gene Chr4:128840300-128851644 (+)
AKR/J ENSMUSG00220037947
 protein coding gene Chr4:127832120-127843477 (+)
BALB/cJ ENSMUSG00180045748
 protein coding gene Chr4:126480554-126491891 (+)
C3H/HeJ ENSMUSG00175041678
 protein coding gene Chr4:127491499-127502845 (+)
C57BL/6NJ ENSMUSG00215050879
 protein coding gene Chr4:129009100-129020409 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026619
 protein coding gene Chr4:124001195-124012979 (+)
CAST/EiJ ENSTCUG00005047262
 protein coding gene Chr4:128397224-128408531 (+)
CBA/J ENSMUSG00210052875
 protein coding gene Chr4:127115299-127126643 (+)
DBA/2J ENSMUSG00185050304
 protein coding gene Chr4:128654051-128665378 (+)
FVB/NJ ENSMUSG00205036275
 protein coding gene Chr4:126887967-126899272 (+)
JF1/MsJ ENSUMUG00000014670
 protein coding gene Chr4:129318746-129330051 (+)
LP/J ENSMUSG00230038331
 protein coding gene Chr4:132437376-132455004 (+)
NOD/ShiLtJ ENSMUSG00190047914
 protein coding gene Chr4:126886377-126897705 (+)
NZO/HlLtJ ENSMUSG00225024538
 protein coding gene Chr4:138369283-138380590 (+)
PWK/PhJ ENSLUMG00010048892
 protein coding gene Chr4:126332272-126343598 (+)
SPRET/EiJ ENSMSPG00010032244
 protein coding gene Chr4:128399489-128411256 (+)
WSB/EiJ ENSIUOG00005042869
 protein coding gene Chr4:126776444-126787773 (+)



Homology
more
  • Human Ortholog
    SLC30A2, solute carrier family 30 member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC30A2, solute carrier family 30 member 2
  • Synonyms
    PP12488, TNZD, ZnT-2, ZNT2
  • Links
    NCBI Gene ID: 7780
    UniProt: Q9BRI3

  • Chr Location
    1p36.11; chr1:26037252-26046136 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal mammary gland development during lactation, abnormal zinc levels in the mammary gland and milk, impaired lactation and decreased litter survival.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    618
  • Tissues
    3
  • cDNA Data
    27
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028836 Ensembl Gene Model | MGI Sequence Detail 11304 C57BL/6J ±  kb
    transcript ENSMUST00000105874 Ensembl | MGI Sequence Detail 3153 Not Applicable  
    polypeptide ENSMUSP00000101500 Ensembl | MGI Sequence Detail 371 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000015075 proton-coupled zinc antiporter SLC30A2
      (term hierarchy)
    • InterPro Domains
      IPR050681 Cation Diffusion Facilitator/SLC30A
      IPR002524 Cation efflux
      IPR027470 Cation efflux protein, cytoplasmic domain
      IPR036837 Cation efflux protein, cytoplasmic domain superfamily
      IPR058533 Cation efflux protein, transmembrane domain
      IPR027469 Cation efflux transmembrane domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 1
      cDNA 28
      Primer pair 1
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-35094
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 1
      Gene Ontology 11
      Phenotypes 20
    • Earliest
      J:32792 Palmiter RD, et al., ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration. EMBO J. 1996 Apr 15;15(8):1784-91
    • Latest
      J:369078 Jose O, et al., Different populations of mouse egg cortical vesicles are responsible for post-fertilization zinc sparks and proteolysis of the zona pellucida. iScience. 2025 Jun 20;28(6):112606
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory