Myo9b MGI Mouse Gene Detail - MGI:106624

Symbol

Myo9b
Name

myosin IXb

Feature Type

protein coding gene
IDs

MGI:106624
NCBI Gene: 17925
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:71725358-71813357 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.43 cM
Mapping Data

6 experiments

SNPs within 2kb

1484 from dbSNP Build 142
Strain Annotations

19
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106624	protein coding gene	Chr8:71725220-71813357 (+)
129S1/SvImJ	ENSMUSG00200029623	protein coding gene	Chr8:66314586-66409667 (+)
A/J	ENSMUSG00195015002	protein coding gene	Chr8:66770536-66858528 (+)
AKR/J	ENSMUSG00220021663	protein coding gene	Chr8:66793920-66896123 (+)
BALB/cJ	ENSMUSG00180027770	protein coding gene	Chr8:66497338-66592421 (+)
C3H/HeJ	ENSMUSG00175020089	protein coding gene	Chr8:66699798-66794870 (+)
C57BL/6NJ	ENSMUSG00215025403	protein coding gene	Chr8:66282857-66370863 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031177	protein coding gene	Chr8:63381774-63468479 (+)
CAST/EiJ	ENSTCUG00005036027	protein coding gene	Chr8:66307820-66395623 (+)
CBA/J	ENSMUSG00210032920	protein coding gene	Chr8:66543414-66638478 (+)
DBA/2J	ENSMUSG00185011467	protein coding gene	Chr8:72703040-72798114 (+)
FVB/NJ	ENSMUSG00205039229	protein coding gene	Chr8:65845042-65890445 (+)
JF1/MsJ	ENSUMUG00000010906	protein coding gene	Chr8:74974236-75062031 (+)
LP/J	ENSMUSG00230027939	protein coding gene	Chr8:76314515-76409602 (+)
NOD/ShiLtJ	ENSMUSG00190022562	protein coding gene	Chr8:66466093-66554065 (+)
NZO/HlLtJ	ENSMUSG00225047109	protein coding gene	Chr8:79714667-79809735 (+)
PWK/PhJ	ENSLUMG00010027200	protein coding gene	Chr8:66438337-66526317 (+)
SPRET/EiJ	ENSMSPG00010038481	protein coding gene	Chr8:68130303-68218100 (+)
WSB/EiJ	ENSIUOG00005021785	protein coding gene	Chr8:67312048-67407184 (+)

Human Ortholog

MYO9B, myosin IXB

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYO9B, myosin IXB
Synonyms

CELIAC4, MYR5
Links

HGNC:7609

NCBI Gene ID: 4650

UniProt: Q13459
Chr Location

19p13.11; chr19:17075728-17214537 (+) GRCh38

MGI Vertebrate Homology

Myo9b stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MYO9B
Gene Tree

Myo9b

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

9
Targeted

4
Genomic Mutations

1 involving Myo9b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

109 strains or lines available

Homozygous null mutants breed normal, but shows defect in macrophage motility and chemotaxis.

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All GO Annotations

78
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

613
Tissues

8
cDNA Data

121
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase myo9b

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All Sequences

114
RefSeq

61
UniProt

9
CCDS

CCDS40379.1, CCDS52580.1, CCDS52581.1

Ensembl

ENSMUSG00000004677 (Evidence)
NCBI Gene

17925

			Length	Strain/Species	Flank
genomic	ENSMUSG00000004677	Ensembl Gene Model \| MGI Sequence Detail	88000	C57BL/6J	± kb
transcript	ENSMUST00000170242	Ensembl \| MGI Sequence Detail	7297	Not Applicable
polypeptide	ENSMUSP00000129220	Ensembl \| MGI Sequence Detail	2128	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000010872 myosin-IXb

(term hierarchy)
InterPro Domains

IPR046349 C1-like domain superfamily

IPR036023 Class IX myosin, motor domain

IPR000048 IQ motif, EF-hand binding site

IPR036961 Kinesin motor domain superfamily

IPR001609 Myosin head, motor domain-like

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR000159 Ras-associating domain

IPR000198 Rho GTPase-activating protein domain

IPR008936 Rho GTPase activation protein

IPR029071 Ubiquitin-like domain superfamily

IPR046987 Unconventional class IX myosin

IPR046989 Unconventional myosin-IXb, RA domain

IPR028557 Unconventional myosin-IXb, Rho-GAP domain

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All nucleic 128

cDNA 122

Primer pair 5

Other 1

Antibodies 1

Microarray probesets 3

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MGD-MRK-35081

Summaries

All 51

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 15
Earliest

J:35477 Hasson T, et al., Mapping of unconventional myosins in mouse and human. Genomics. 1996 Sep 15;36(3):431-9
Latest

J:341223 Zhang J, et al., Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset. Nat Commun. 2023 Sep 25;14(1):5977

TSS for Myo9b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77838	Chr8:71725334-71725390 (+)	4 bp
Tssr77839	Chr8:71725393-71725428 (+)	53 bp
Tssr77840	Chr8:71763324-71763354 (+)	37,981 bp
Tssr77841	Chr8:71783353-71783389 (+)	58,013 bp
Tssr77842	Chr8:71790061-71790075 (+)	64,710 bp
Tssr77843	Chr8:71798795-71798798 (+)	73,439 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24