Rnf112 MGI Mouse Gene Detail - MGI:106611

Symbol

Rnf112
Name

ring finger protein 112
Synonyms

bfp, neurolastin, Zfp179

Feature Type

protein coding gene
IDs

MGI:106611
NCBI Gene: 22671
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:61339268-61344957 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.96 cM, cytoband B1.3
Mapping Data

5 experiments

SNPs within 2kb

45 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106611	protein coding gene	Chr11:61339243-61345014 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018438	protein coding gene	Chr11:61411020-61416709 (-)
A/J	MGP_AJ_G0018407	protein coding gene	Chr11:59141462-59147151 (-)
AKR/J	MGP_AKRJ_G0018377	protein coding gene	Chr11:60982462-60988294 (-)
BALB/cJ	MGP_BALBcJ_G0018378	protein coding gene	Chr11:59448109-59453798 (-)
C3H/HeJ	MGP_C3HHeJ_G0018191	protein coding gene	Chr11:60963155-60968844 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018830	protein coding gene	Chr11:63352448-63358137 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016476	protein coding gene	Chr11:56268361-56274063 (-)
CAST/EiJ	MGP_CASTEiJ_G0017748	protein coding gene	Chr11:61070089-61075925 (-)
CBA/J	MGP_CBAJ_G0018165	protein coding gene	Chr11:66100094-66105784 (-)
DBA/2J	MGP_DBA2J_G0018274	protein coding gene	Chr11:58716394-58722082 (-)
FVB/NJ	MGP_FVBNJ_G0018265	protein coding gene	Chr11:58401257-58406946 (-)
LP/J	MGP_LPJ_G0018347	protein coding gene	Chr11:61977545-61983389 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018289	protein coding gene	Chr11:67121743-67127431 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018871	protein coding gene	Chr11:61117587-61123276 (-)
PWK/PhJ	MGP_PWKPhJ_G0017521	protein coding gene	Chr11:59313470-59319294 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017311	protein coding gene	Chr11:60935617-60941308 (-)
WSB/EiJ	MGP_WSBEiJ_G0017800	protein coding gene	Chr11:60723983-60729672 (-)

Human Ortholog

RNF112, ring finger protein 112

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF112, ring finger protein 112
Synonyms

BFP, ZNF179
Links

HGNC:12968

NCBI Gene ID: 7732

neXtProt AC: NX_Q9ULX5

UniProt: Q9ULX5
Chr Location

17p11.2; chr17:19407169-19417276 (+) GRCh38.p7

Alliance of Genome Resources

Rnf112 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RNF112
Gene Tree

Rnf112

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References

2 with disease annotations

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

8
Genomic Mutations

3 involving Rnf112
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced dendritic spines, functional synapses and paired pulse facilitation.

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All GO Annotations

40
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

762
Tissues

46
cDNA Data

16
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnf112, rnf112.1

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Rnf112 interacts with 122 markers (Mir7-2, Mir7b, Mir9-1, ...) View All

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All Sequences

73
RefSeq

30
UniProt

1
CCDS

CCDS24812.1, CCDS78960.1, CCDS88167.1

Ensembl

ENSMUSG00000010086 (Evidence)
NCBI Gene

22671

			Length	Strain/Species	Flank
genomic	ENSMUSG00000010086	Ensembl Gene Model \| MGI Sequence Detail	5690	C57BL/6J	± kb
transcript	ENSMUST00000060255	Ensembl \| MGI Sequence Detail	3161	Not Applicable
polypeptide	ENSMUSP00000059903	Ensembl \| MGI Sequence Detail	679	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014068 RING finger protein 112

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain

IPR015894 Guanylate-binding protein, N-terminal

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR018957 Zinc finger, C3HC4 RING-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

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All nucleic 19

Genomic 2

cDNA 17

Microarray probesets 5

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MGD-MRK-35068, MGI:2144319, MGI:2144714

Summaries

All 59

Developmental Gene Expression 7

Diseases 2

Gene Ontology 12

Phenotypes 24
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:294447 Haage V, et al., Tenascin C regulates multiple microglial functions involving TLR4 signaling and HDAC1. Brain Behav Immun. 2019 Oct;81:470-483

TSS for Rnf112:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108355	Chr11:61344818-61344845 (-)	125 bp
Tssr108354	Chr11:61344747-61344808 (-)	179 bp
Tssr108353	Chr11:61344716-61344736 (-)	231 bp
Tssr108352	Chr11:61344683-61344692 (-)	269 bp
Tssr108351	Chr11:61344342-61344379 (-)	596 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 01/31/2023 MGI 6.22