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Neurod6 Gene Detail
Summary
  • Symbol
    Neurod6
  • Name
    neurogenic differentiation 6
  • Synonyms
    Atoh2, bHLHa2, Math-2, Math2, Nex, Nex1m
  • Feature Type
    protein coding gene
  • IDs
    MGI:106593
    NCBI Gene: 11922
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:55654807-55658248 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 27.53 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106593
 protein coding gene Chr6:55654803-55658248 (-)
129S1/SvImJ ENSMUSG00200005365
 protein coding gene Chr6:52623473-52626922 (-)
A/J ENSMUSG00195032455
 protein coding gene Chr6:52361411-52364856 (-)
AKR/J ENSMUSG00220005591
 protein coding gene Chr6:52057856-52061301 (-)
BALB/cJ ENSMUSG00180008997
 protein coding gene Chr6:52655328-52658769 (-)
C3H/HeJ ENSMUSG00175036514
 protein coding gene Chr6:52419543-52422986 (-)
C57BL/6NJ ENSMUSG00215021895
 protein coding gene Chr6:52640172-52643615 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028417
 protein coding gene Chr6:50139554-50142998 (-)
CAST/EiJ ENSTCUG00005038896
 protein coding gene Chr6:51889455-51892904 (-)
CBA/J ENSMUSG00210030979
 protein coding gene Chr6:52460756-52464199 (-)
DBA/2J ENSMUSG00185018580
 protein coding gene Chr6:53040387-53043830 (-)
FVB/NJ ENSMUSG00205022013
 protein coding gene Chr6:52690372-52693813 (-)
JF1/MsJ ENSUMUG00000019239
 protein coding gene Chr6:52420858-52424299 (-)
LP/J ENSMUSG00230009627
 protein coding gene Chr6:54120482-54123931 (-)
NOD/ShiLtJ ENSMUSG00190008527
 protein coding gene Chr6:52371957-52375400 (-)
NZO/HlLtJ ENSMUSG00225012500
 protein coding gene Chr6:56112148-56115597 (-)
PWK/PhJ ENSLUMG00010017309
 protein coding gene Chr6:52162334-52165789 (-)
SPRET/EiJ ENSMSPG00010008927
 protein coding gene Chr6:52782289-52785729 (-)
WSB/EiJ ENSIUOG00005020373
 protein coding gene Chr6:52720546-52723988 (-)



Homology
more
  • Human Ortholog
    NEUROD6, neuronal differentiation 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEUROD6, neuronal differentiation 6
  • Synonyms
    Atoh2, bHLHa2, Math-2, MATH2, Nex1, NEX1M
  • Links
    NCBI Gene ID: 63974
    UniProt: Q96NK8

  • Chr Location
    7p14.3; chr7:31337465-31340726 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    71 phenotypes from multigenic genotypes
    399 phenotype references
Mice homozygous for a targeted null mutation are viable and fertile and exhibit an apparently normal differentiation of CNS neurons with no obvious behavioral or motor abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1075
  • Tissues
    272
  • cDNA Data
    21
  • Literature Summary
    84
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037984 Ensembl Gene Model | MGI Sequence Detail 3442 C57BL/6J ±  kb
transcript ENSMUST00000044767 Ensembl | MGI Sequence Detail 2150 Not Applicable  
polypeptide ENSMUSP00000047016 Ensembl | MGI Sequence Detail 337 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011155 neurogenic differentiation factor 6
    (term hierarchy)
  • InterPro Domains
    IPR050359 Basic helix-loop-helix transcription factors
    IPR036638 Helix-loop-helix DNA-binding domain superfamily
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR022575 Neurogenic differentiation factor, domain of unknown function
    IPR016637 Neurogenic differentiation factor NeuroD
Molecular
Reagents
less
  • All nucleic 39
    Genomic 2
    cDNA 22
    Primer pair 9
    Other 6

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35049
References
more
  • Summaries
    All 513
    Developmental Gene Expression 84
    Diseases 1
    Gene Ontology 6
    Phenotypes 399
  • Earliest
    J:33073 Bartholoma A, et al., NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons. Mech Dev. 1994 Dec;48(3):217-28
  • Latest
    J:391214 Ferrigno SM, et al., Indirect pathway neurons in the tail of the striatum regulate inhibitory control over sensory driven behavior. Sci Adv. 2026 Jul 31;12(31):eaeb5352
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory