Mtg2 MGI Mouse Gene Detail - MGI:106565 - mitochondrial ribosome associated GTPase 2

Symbol

Mtg2
Name

mitochondrial ribosome associated GTPase 2
Synonyms

1810011P19Rik, 2900056P18Rik, D2Bwg0647e, Gtpbp5

Feature Type

protein coding gene
IDs

MGI:106565
NCBI Gene: 52856
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:179712381-179727695 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 102.59 cM, cytoband H4
Mapping Data

4 experiments

SNPs within 2kb

406 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106565	protein coding gene	Chr2:179712366-179727695 (+)
129S1/SvImJ	ENSMUSG00200001987	protein coding gene	Chr2:175735228-175750765 (+)
A/J	ENSMUSG00195001047	protein coding gene	Chr2:175972501-175988042 (+)
AKR/J	ENSMUSG00220000094	protein coding gene	Chr2:173651071-173666624 (+)
BALB/cJ	ENSMUSG00180000281	protein coding gene	Chr2:173774617-173790162 (+)
C3H/HeJ	ENSMUSG00175004263	protein coding gene	Chr2:174934476-174950057 (+)
C57BL/6NJ	ENSMUSG00215002554	protein coding gene	Chr2:173873446-173889026 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024773	protein coding gene	Chr2:169597758-169613129 (+)
CAST/EiJ	ENSTCUG00005000720	protein coding gene	Chr2:173223349-173238855 (+)
CBA/J	ENSMUSG00210001092	protein coding gene	Chr2:174252690-174268230 (+)
DBA/2J	ENSMUSG00185020861	protein coding gene	Chr2:175493888-175509473 (+)
FVB/NJ	ENSMUSG00205002123	protein coding gene	Chr2:174300328-174315868 (+)
JF1/MsJ	ENSUMUG00000013910	protein coding gene	Chr2:176670328-176685863 (+)
LP/J	ENSMUSG00230024498	protein coding gene	Chr2:177386199-177401737 (+)
NOD/ShiLtJ	ENSMUSG00190016321	protein coding gene	Chr2:173794322-173809863 (+)
NZO/HlLtJ	ENSMUSG00225006658	protein coding gene	Chr2:185474504-185490081 (+)
PWK/PhJ	ENSLUMG00010000107	protein coding gene	Chr2:174097892-174113361 (+)
SPRET/EiJ	ENSMSPG00010003920	protein coding gene	Chr2:176575984-176590210 (+)
WSB/EiJ	ENSIUOG00005000182	protein coding gene	Chr2:173819112-173834674 (+)

Human Ortholog

MTG2, mitochondrial ribosome associated GTPase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MTG2, mitochondrial ribosome associated GTPase 2
Synonyms

dJ1005F21.2, GTPBP5, ObgH1
Links

HGNC:16239

NCBI Gene ID: 26164

UniProt: Q9H4K7
Chr Location

20q13.33; chr20:62183025-62203568 (+) GRCh38

MGI Vertebrate Homology

Mtg2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MTG2
Protein SuperFamily

GTP_bd_Obg/CgtA
Gene Tree

Mtg2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

53
Endonuclease-mediated

5
Gene trapped

46
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

39
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

32

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mtg2

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All Sequences

140
RefSeq

80
UniProt

4
CCDS

CCDS38374.1

Ensembl

ENSMUSG00000039069 (Evidence)
NCBI Gene

52856

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039069	Ensembl Gene Model \| MGI Sequence Detail	15315	C57BL/6J	± kb
transcript	ENSMUST00000108901	Ensembl \| MGI Sequence Detail	1444	Not Applicable
polypeptide	ENSMUSP00000104529	Ensembl \| MGI Sequence Detail	405	Not Applicable

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UniProt

4 Sequences
InterPro Domains

IPR006169 GTP1/OBG domain

IPR036726 GTP1/OBG domain superfamily

IPR006073 GTP binding domain

IPR014100 GTP-binding protein Obg/CgtA

IPR045086 OBG-type GTPase

IPR031167 OBG-type guanine nucleotide-binding (G) domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR005225 Small GTP-binding domain

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All nucleic 34

cDNA 33

Primer pair 1

Microarray probesets 6

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MGD-MRK-34259, MGI:1916328, MGI:1920301

Summaries

All 44

Gene Ontology 8

Phenotypes 13
Earliest

J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mtg2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22207	Chr2:179712369-179712404 (+)	6 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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