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Larp4b Gene Detail
Summary
  • Symbol
    Larp4b
  • Name
    La ribonucleoprotein 4B
  • Synonyms
    D13Wsu64e, Larp5
  • Feature Type
    protein coding gene
  • IDs
    MGI:106330
    NCBI Gene: 217980
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:9143917-9224487 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, Syntenic
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1599 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106330
 protein coding gene Chr13:9143643-9224487 (+)
129S1/SvImJ ENSMUSG00200005836
 protein coding gene Chr13:6319038-6399609 (+)
A/J ENSMUSG00195012209
 protein coding gene Chr13:5725200-5805773 (+)
AKR/J ENSMUSG00220012786
 protein coding gene Chr13:5985129-6066372 (+)
BALB/cJ ENSMUSG00180009398
 protein coding gene Chr13:6130744-6211318 (+)
C3H/HeJ ENSMUSG00175008438
 protein coding gene Chr13:6179481-6260052 (+)
C57BL/6NJ ENSMUSG00215011243
 protein coding gene Chr13:6432431-6513006 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018216
 protein coding gene Chr13:5663370-5746740 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210022683
 protein coding gene Chr13:5706995-5787567 (+)
DBA/2J ENSMUSG00185024158
 protein coding gene Chr13:6395546-6476357 (+)
FVB/NJ ENSMUSG00205021856
 protein coding gene Chr13:6147194-6227763 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230006325
 protein coding gene Chr13:15910034-15911858 (+)
LP/J ENSMUSGG00230055828
 protein coding gene Chr13:15916378-15963016 (+)
NOD/ShiLtJ ENSMUSG00190013020
 protein coding gene Chr13:5842275-5923495 (+)
NZO/HlLtJ ENSMUSGG00225055508
 protein coding gene Chr13:9820403-9867042 (+)
NZO/HlLtJ ENSMUSG00225033802
 protein coding gene Chr13:9814059-9815883 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    LARP4B, La ribonucleoprotein 4B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LARP4B, La ribonucleoprotein 4B
  • Synonyms
    KIAA0217, LARP5
  • Links
    NCBI Gene ID: 23185
    UniProt: Q92615

  • Chr Location
    10p15.3; chr10:806914-988341 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    622
  • Tissues
    3
  • cDNA Data
    22
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033499 Ensembl Gene Model | MGI Sequence Detail 80571 C57BL/6J ±  kb
    transcript ENSMUST00000381824 Ensembl | MGI Sequence Detail 8283 Not Applicable  
    polypeptide ENSMUSP00000160194 Ensembl | MGI Sequence Detail 1723 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000009671 La-related protein 4B
      (term hierarchy)
    • InterPro Domains
      IPR045180 La domain containing protein
      IPR058699 LARP4/4B, RNA recognition motif
      IPR034900 LARP4B, RNA recognition motif
      IPR006630 La-type HTH domain
      IPR035979 RNA-binding domain superfamily
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    • GlyGen
      Q6A0A2 10 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (8 sites)
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 22
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-34022, MGI:2145195, MGI:3045272
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory