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Ermp1 Gene Detail
Summary
  • Symbol
    Ermp1
  • Name
    endoplasmic reticulum metallopeptidase 1
  • Synonyms
    b2b2633Clo, D19Ertd410e, D19Wsu12e, MGC:28180, mKIAA1815
  • Feature Type
    protein coding gene
  • IDs
    MGI:106250
    NCBI Gene: 226090
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:29587276-29625815 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 24.17 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1108 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106250
 protein coding gene Chr19:29585614-29625815 (-)
129S1/SvImJ ENSMUSG00200020250
 protein coding gene Chr19:26322386-26362637 (-)
A/J ENSMUSG00195034886
 protein coding gene Chr19:26477223-26517463 (-)
AKR/J ENSMUSG00220018710
 protein coding gene Chr19:26536606-26576834 (-)
BALB/cJ ENSMUSG00180012926
 protein coding gene Chr19:26805985-26846222 (-)
C3H/HeJ ENSMUSG00175024294
 protein coding gene Chr19:26182091-26222307 (-)
C57BL/6NJ ENSMUSG00215017459
 protein coding gene Chr19:26222542-26262746 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022861
 protein coding gene Chr19:26634124-26674676 (-)
CAST/EiJ ENSTCUG00005017548
 protein coding gene Chr19:26045185-26085618 (-)
CBA/J ENSMUSG00210014470
 protein coding gene Chr19:26413061-26453256 (-)
DBA/2J ENSMUSG00185025688
 protein coding gene Chr19:26799800-26840007 (-)
FVB/NJ ENSMUSG00205010943
 protein coding gene Chr19:26193861-26234097 (-)
JF1/MsJ ENSUMUG00000025652
 protein coding gene Chr19:27016429-27057573 (-)
LP/J ENSMUSG00230027880
 protein coding gene Chr19:27616024-27656270 (-)
NOD/ShiLtJ ENSMUSG00190019075
 protein coding gene Chr19:26176564-26216796 (-)
NZO/HlLtJ ENSMUSG00225029189
 protein coding gene Chr19:31369323-31409556 (-)
PWK/PhJ ENSLUMG00010032794
 protein coding gene Chr19:26403187-26444373 (-)
SPRET/EiJ ENSMSPG00010030704
 protein coding gene Chr19:26355431-26396439 (-)
WSB/EiJ ENSIUOG00005026958
 protein coding gene Chr19:25908551-25948532 (-)



Homology
more
  • Human Ortholog
    ERMP1, endoplasmic reticulum metallopeptidase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERMP1, endoplasmic reticulum metallopeptidase 1
  • Synonyms
    bA207C16.3, FXNA, KIAA1815
  • Links
    NCBI Gene ID: 79956
    UniProt: Q7Z2K6

  • Chr Location
    9p24.1; chr9:5749832-5879537 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ermp1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit early embryonic lethality. Heterozygotes exhibit loss of renal function over time, glomerular hyperfiltration, proteinuria, increased renal inflammation and fibrosis with age. Mice homozygous for an ENU-induced mutation exhibit cardiovascular defects, anopthalmia, renal dysplasia, and craniofacial anomalies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    684
  • Tissues
    51
  • cDNA Data
    150
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 226090 NCBI Gene Model | MGI Sequence Detail 38540 C57BL/6J ±  kb
    transcript NM_001362131 RefSeq | MGI Sequence Detail 5399 ZRU/MplStud  
    polypeptide Q3UVK0 UniProt | EBI | MGI Sequence Detail 898 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007184 endoplasmic reticulum metallopeptidase 1
      (term hierarchy)
    • EC
      3.4.-.-
    • InterPro Domains
      IPR053974 Endoplasmic reticulum metallopeptidase 1/1-A, TM domain
      IPR053973 Endoplasmic reticulum metallopeptidase 1-like, C-terminal domain
      IPR048024 Endoplasmic reticulum metallopeptidase 1-like, M28 peptidase domain
      IPR007484 Peptidase M28
      IPR045175 Peptidase M28 family
    • GlyGen
      Q3UVK0 2 sites, 3 N-linked glycans (1 site)
    Molecular
    Reagents
    less
    • All nucleic 153
      cDNA 150
      Primer pair 2
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-33942, MGI:1196241, MGI:5615213
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:382962 Gjorgjieva M, et al., Hepatoprotective role for ERMP1 in MASLD-driven hepatocarcinogenesis and beta-catenin-mutated tumors. Cancer Lett. 2026;647:218427
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory