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Aqp5 Gene Detail
Summary
  • Symbol
    Aqp5
  • Name
    aquaporin 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:106215
    NCBI Gene: 11830
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:99488909-99492710 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.13 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106215
 protein coding gene Chr15:99488663-99492710 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022335
 protein coding gene Chr15:101449425-101453405 (+)
A/J MGP_AJ_G0022293
 protein coding gene Chr15:97404401-97408381 (+)
AKR/J MGP_AKRJ_G0022269
 protein coding gene Chr15:100403881-100407861 (+)
BALB/cJ MGP_BALBcJ_G0022299
 protein coding gene Chr15:97589610-97593589 (+)
C3H/HeJ MGP_C3HHeJ_G0022067
 protein coding gene Chr15:100466807-100472323 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022744
 protein coding gene Chr15:105233774-105237754 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020270
 protein coding gene Chr15:93300062-93303897 (+)
CAST/EiJ MGP_CASTEiJ_G0021592
 protein coding gene Chr15:101338881-101342880 (+)
CBA/J MGP_CBAJ_G0022036
 protein coding gene Chr15:108797707-108801686 (+)
DBA/2J MGP_DBA2J_G0022163
 protein coding gene Chr15:96840835-96844815 (+)
FVB/NJ MGP_FVBNJ_G0022143
 protein coding gene Chr15:95830086-95834222 (+)
LP/J MGP_LPJ_G0022234
 protein coding gene Chr15:101596102-101600082 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022163
 protein coding gene Chr15:112711138-112716036 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022759
 protein coding gene Chr15:100513136-100517116 (+)
PWK/PhJ MGP_PWKPhJ_G0021330
 protein coding gene Chr15:96982487-96986465 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021165
 protein coding gene Chr15:100361784-100365763 (+)
WSB/EiJ MGP_WSBEiJ_G0021642
 protein coding gene Chr15:101032907-101036886 (+)



Homology
more
  • Human Ortholog
    AQP5, aquaporin 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AQP5, aquaporin 5
  • Synonyms
    AQP-5, PPKB
  • Links
    NCBI Gene ID: 362
    neXtProt AC: NX_P55064
    UniProt: P55064

  • Chr Location
    12q13.12; chr12:49961872-49965682 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Aqp5 mouse models; 1 with human AQP5 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    81 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit reduced growth on solid food and secrete diminished amounts of hypertonic, viscous saliva.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    986
  • Tissues
    120
  • cDNA Data
    98
  • Literature Summary
    148
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11830 NCBI Gene Model | MGI Sequence Detail 3802 C57BL/6J ±  kb
    transcript NM_009701 RefSeq | MGI Sequence Detail 1551 ZRU/MplStud  
    polypeptide Q9WTY4 UniProt | EBI | MGI Sequence Detail 265 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 123
      Genomic 2
      cDNA 99
      Primer pair 19
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33907
    References
    more
    • Summaries
      All 273
      Developmental Gene Expression 148
      Diseases 2
      Gene Ontology 16
      Phenotypes 81
    • Earliest
      J:34248 Steinman RM, et al., Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice. J Exp Med. 1983 Feb 1;157(2):613-27
    • Latest
      J:344499 Cao X, et al., Aquaporin5 Deficiency Aggravates ROS/NLRP3 Inflammasome-Mediated Pyroptosis in the Lacrimal Glands. Invest Ophthalmol Vis Sci. 2023 Jan 3;64(1):4
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory