About   Help   FAQ
Vegfb Gene Detail
Summary
  • Symbol
    Vegfb
  • Name
    vascular endothelial growth factor B
  • Synonyms
    VEGF-B, Vrf
  • Feature Type
    protein coding gene
  • IDs
    MGI:106199
    NCBI Gene: 22340
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6959841-6965019 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.12 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106199
 protein coding gene Chr19:6959840-6965019 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024777
 protein coding gene Chr19:4076349-4083046 (-)
A/J MGP_AJ_G0024744
 protein coding gene Chr19:3745784-3751279 (-)
AKR/J MGP_AKRJ_G0024717
 protein coding gene Chr19:3869797-3874906 (-)
BALB/cJ MGP_BALBcJ_G0024744
 protein coding gene Chr19:3855114-3860304 (-)
C3H/HeJ MGP_C3HHeJ_G0024512
 protein coding gene Chr19:3991967-3997170 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025190
 protein coding gene Chr19:4171383-4176492 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022624
 protein coding gene Chr19:3652142-3657542 (-)
CAST/EiJ MGP_CASTEiJ_G0023984
 protein coding gene Chr19:3899181-3905689 (-)
CBA/J MGP_CBAJ_G0024484
 protein coding gene Chr19:4221064-4228916 (-)
DBA/2J MGP_DBA2J_G0024611
 protein coding gene Chr19:3717553-3722657 (-)
FVB/NJ MGP_FVBNJ_G0024576
 protein coding gene Chr19:3747687-3752850 (-)
LP/J MGP_LPJ_G0024697
 protein coding gene Chr19:3940500-3945625 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024606
 protein coding gene Chr19:4129486-4135854 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025238
 protein coding gene Chr19:4002211-4008990 (-)
PWK/PhJ MGP_PWKPhJ_G0023730
 protein coding gene Chr19:3761615-3766762 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023534
 protein coding gene Chr19:3821336-3826413 (-)
WSB/EiJ MGP_WSBEiJ_G0024046
 protein coding gene Chr19:3905763-3911934 (-)



Homology
more
  • Human Ortholog
    VEGFB, vascular endothelial growth factor B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VEGFB, vascular endothelial growth factor B
  • Synonyms
    VEGFL, VRF
  • Links
    NCBI Gene ID: 7423
    neXtProt AC: NX_P49765
    UniProt: P49765

  • Chr Location
    11q13.1; chr11:64234584-64239264 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human VEGFB associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 4 alleles in 4 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one or more disruptions in this gene display defective cardiac morphology and physiology, sensitivity to induced neurodegeneration, increased weight and brown adipose whitening.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1111
  • Tissues
    244
  • cDNA Data
    44
  • Literature Summary
    41
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024962 Ensembl Gene Model | MGI Sequence Detail 5179 C57BL/6J ±  kb
    transcript ENSMUST00000025914 Ensembl | MGI Sequence Detail 1281 Not Applicable  
    polypeptide ENSMUSP00000025914 Ensembl | MGI Sequence Detail 207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 2
      cDNA 44
      Primer pair 7
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33890
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 41
      Gene Ontology 8
      Phenotypes 33
    • Earliest
      J:31999 Lagercrantz J, et al., Expression of the VEGF-related factor gene in pre- and postnatal mouse. Biochem Biophys Res Commun. 1996 Mar 7;220(1):147-52
    • Latest
      J:339873 Lee C, et al., VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway. Signal Transduct Target Ther. 2023 Aug 18;8(1):305
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory